The extracellular matrix glycoprotein tenascin-R regulates neurogenesis during development and in the adult dentate gyrus of mice

Xu, Jinyong; Xiao, Mei Fang; Jakovčevski, Igor; Sivukhina, Elena; Hargus, Gunnar; Cui, Yi; Irintchev, Andrey; Schachner, Melitta; Bernreuther, Christian

doi:10.1242/jcs.137612

Cited by 34 publications

(21 citation statements)

References 71 publications

(51 reference statements)

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“…Some genes ( SLIT1 , TNR , FAM181B , IFT172 , PPM1G , SNX17 , and PREB ) associated with neural development [38, 39, 40, 41, 58, 59, 60, 61, 62, 63] were also found in the top 20 significant windows for both traits. Costa et al [10] also detected genes related to neural development that were associated with reproductive traits.…”

Section: Resultsmentioning

confidence: 99%

Genome-wide association study provides strong evidence of genes affecting the reproductive performance of Nellore beef cows

et al. 2017

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Reproductive traits are economically important for beef cattle production; however, these traits are still a bottleneck in indicine cattle since these animals typically reach puberty at older ages when compared to taurine breeds. In addition, reproductive traits are complex phenotypes, i.e., they are controlled by both the environment and many small-effect genes involved in different pathways. In this study, we conducted genome-wide association study (GWAS) and functional analyses to identify important genes and pathways associated with heifer rebreeding (HR) and with the number of calvings at 53 months of age (NC53) in Nellore cows. A total of 142,878 and 244,311 phenotypes for HR and NC53, respectively, and 2,925 animals genotyped with the Illumina Bovine HD panel (Illumina®, San Diego, CA, USA) were used in GWAS applying the weighted single-step GBLUP (WssGBLUP) method. Several genes associated with reproductive events were detected in the 20 most important 1Mb windows for both traits. Significant pathways for HR and NC53 were associated with lipid metabolism and immune processes, respectively. MHC class II genes, detected on chromosome 23 (window 25-26Mb) for NC53, were significantly associated with pregnancy success of Nellore cows. These genes have been proved previously to be associated with reproductive traits such as mate choice in other breeds and species. Our results suggest that genes associated with the reproductive traits HR and NC53 may be involved in embryo development in mammalian species. Furthermore, some genes associated with mate choice may affect pregnancy success in Nellore cattle.

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Section: Resultsmentioning

confidence: 99%

Genome-wide association study provides strong evidence of genes affecting the reproductive performance of Nellore beef cows

et al. 2017

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“…In the olfactory bulb, the related gene Tnr attracts the neuroblasts into the periglomerular networks (Saghatelyan et al, 2004). The latter glycoprotein Tnr also seems of importance in the neurogenic zone of the adult hippocampus, since the Tnr knock-out mouse line shows an increased number of GABAergic neurons, a reduced expression of b1-integrin, an enhanced activation of p38 MAPK and an augmented expression of the GABAergic specification gene Ascl1 (Xu et al, 2014). Interestingly, Tnc is not only found in the NSC niche, but also in stem cell niches of other organs and hence emerges as a constitutive element in various stem cell microenvironments (Chiquet-Ehrismann et al, 2014).…”

Section: Tenascin Proteins In the Adult Nsc Nichementioning

confidence: 99%

The extracellular matrix compartment of neural stem and glial progenitor cells

Faissner

Reinhard

2015

Glia

103

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Neuroepithelial and radial GLIA stem cells generate the majority of the cellular constituents of the central nervous system. Following precisely timed phases of neurogenesis and gliogenesis the stem cells recede, with the exception of adult neural stem cells that persist in two generally accepted canonical neurogenic regions, the subventricular zone of the lateral ventricle and the subgranular zone in the dentate gyrus of the hippocampus. It is believed that adult stem cells reside in privileged stem cell niche environments that provide favorable conditions for self-renewal and maintenance of this cellular compartment. Factors such as morphogens, cytokines, and growth factors influence the developmental pathway of neural stem/progenitor cells. By comparison, less is known about the regulatory roles of glycoproteins and proteoglycans of the extracellular matrix (ECM) and their receptors, although they represent important constituents of the micromolecular environment of the niche. Here, we summarize studies that indicate pivotal roles of the ECM micromilieu for the biology and instrumental use of glial stem and progenitor cells of the CNS. Advancing our understanding of structure-function relationships, signaling motifs and complementary receptors and their signal transduction pathways will be of central importance for the application of these cell types in regenerative medicine.

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“…TN-R has also a modular structure like TN-C, but forms trimers instead of hexamers (Joester and Faissner, 2001). TN-R interacts with Integrins, for example β1 Integrins (Xu et al, 2014), Contactin/F3/F11, Phosphacan (Jones and Jones, 2000a), and Myelin-associated glycoprotein (MAG; Yang et al, 1999). TN-R is expressed after spinal cord injury (Apostolova et al, 2006) and in the lesioned optic nerve by an increased number of cells (Becker et al, 2000).…”

Section: Extracellular Signals Influence Regeneration and Stem/progenmentioning

confidence: 99%

Influence of the extracellular matrix on endogenous and transplanted stem cells after brain damage

Roll

Faissner

2014

Front. Cell. Neurosci.

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The limited regeneration capacity of the adult central nervous system (CNS) requires strategies to improve recovery of patients. In this context, the interaction of endogenous as well as transplanted stem cells with their environment is crucial. An understanding of the molecular mechanisms could help to improve regeneration by targeted manipulation. In the course of reactive gliosis, astrocytes upregulate Glial fibrillary acidic protein (GFAP) and start, in many cases, to proliferate. Beside GFAP, subpopulations of these astroglial cells coexpress neural progenitor markers like Nestin. Although cells express these markers, the proportion of cells that eventually give rise to neurons is limited in many cases in vivo compared to the situation in vitro. In the first section, we present the characteristics of endogenous progenitor-like cells and discuss the differences in their neurogenic potential in vitro and in vivo. As the environment plays an important role for survival, proliferation, migration, and other processes, the second section of the review describes changes in the extracellular matrix (ECM), a complex network that contains numerous signaling molecules. It appears that signals in the damaged CNS lead to an activation and de-differentiation of astrocytes, but do not effectively promote neuronal differentiation of these cells. Factors that influence stem cells during development are upregulated in the damaged brain as part of an environment resembling a stem cell niche. We give a general description of the ECM composition, with focus on stem cell-associated factors like the glycoprotein Tenascin-C (TN-C). Stem cell transplantation is considered as potential treatment strategy. Interaction of transplanted stem cells with the host environment is critical for the outcome of stem cell-based therapies. Possible mechanisms involving the ECM by which transplanted stem cells might improve recovery are discussed in the last section.

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The extracellular matrix glycoprotein tenascin-R regulates neurogenesis during development and in the adult dentate gyrus of mice

Cited by 34 publications

References 71 publications

Genome-wide association study provides strong evidence of genes affecting the reproductive performance of Nellore beef cows

Genome-wide association study provides strong evidence of genes affecting the reproductive performance of Nellore beef cows

The extracellular matrix compartment of neural stem and glial progenitor cells

Influence of the extracellular matrix on endogenous and transplanted stem cells after brain damage

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