The extracellular matrix architecture relating to myotendinous pattern formation in the distal part of the developing chick limb: An ultrastructural, histochemical and immunocytochemical analysis

Hurlé, Juan M.; Ros, María A.; Hinchliffe, J. R.; Critchlow, Matthew A.; Génis‐Gálvez, J. M.

doi:10.1016/0922-3371(89)90740-5

Cited by 51 publications

(45 citation statements)

References 22 publications

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“…The pattern visualized by FB1 resembled a characteristic arrangement of the argyrophilic fibrils reported in the developing limb bud by Hurle et al (1988Hurle et al ( , 1989. Nevertheless, we found that the FB1 epitope is localized immunoelectron-microscopically in the bundles of subectodermal microfibrils, and that the electrophoretic mobility and immunohistochemical distribution of the FB1 antigen are indistinguishable from those of JB3 antigen, or chicken fibrillin-2 Rongish et al, 1998).…”

supporting

confidence: 72%

“…We also suggest that the unique array of microfibrillar bundles in the limb bud autopodial plate corresponds to the system of dorsoventally-oriented argyrophilic fibrils (Fig. 5a) (Hurle et al, 1988(Hurle et al, , 1989. Although argyrophilic fibers are often called reticular fibers, which are believed to be collagenous, collagen fibrils were extremely scarce and it is unlikely that they would form a distinct fiber array in the subectodermal region prior to overt development of the dermis (Fig.…”

Section: Discussionmentioning

confidence: 82%

“…5). It has been suggested that the latter play a role in the flattening of the digital/toe plate by pulling the dorsal and ventral ectoderm together (Hurle et al, 1989).…”

Section: Resultsmentioning

confidence: 99%

“…Deparaffinized and hydrated sections were treated according to a standard (Bielshowsky's) silver impregnation technique, with one major change: the silver nitrate solution was replaced by one prepared according to a protocol described by Naoumenko and Feigin (1974), because the latter gave more reproducible results. Some sections were proccessed according to the method of Jones (1951), which Hurle et al (1989) utilized to demonstrate dorsoventrally oriented fibrils in the limb bud.…”

Section: Silver Stainingmentioning

confidence: 99%

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Subectodermal microfibrillar bundles are organized into a distinct parallel array in the developing chick limb bud

et al. 2004

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In this study, a unique fiber system in the subectodermal mesenchyme of the chick limb bud was visualized immunohistochemically with the use of a novel monoclonal antibody termed "FB1." This antibody stained a subset of extracellular fibers in the embryonic mesenchyme. Among the fibers visualized, those running perpendicularly to the limb bud ectoderm became progressively prominent in their thickness and length, and organized into a parallel array in the subectodermal region. This fiber system was distinct from that of major collagens, fibronectin, or tenascin. A molecule immunoprecipitated with FB1 comigrated with JB3 antigen, or chicken fibrillin-2. The fibers visualized immunohistochemically by FB1 and JB3 were indistinguishable from each other, and ultrastructurally appeared to be bundles composed of tubular-like microfibrils that originated directly from the ectodermal basal lamina. They lacked the amorphous deposits that are characteristic of elastin. A similar array of subectodermal fibers was also found in the developing axilla and some truncal regions, again well before the development of a definitive dermis. These findings suggest that a parallel array of subectodermal FB1-positive fibers constitutes a precocious fiber system in the presumptive dermis prior to the substantial formation of collagenous fibers. These fibers could be developmentally linked to oxytalan fibers, which are known to be present in the papillary dermis in mature cutaneous tissue.

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supporting

confidence: 72%

Section: Discussionmentioning

confidence: 82%

“…5). It has been suggested that the latter play a role in the flattening of the digital/toe plate by pulling the dorsal and ventral ectoderm together (Hurle et al, 1989).…”

Section: Resultsmentioning

confidence: 99%

Section: Silver Stainingmentioning

confidence: 99%

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Subectodermal microfibrillar bundles are organized into a distinct parallel array in the developing chick limb bud

et al. 2004

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“…Of interest, we detected a very similar expression pattern for fibronectin to that of collagen type III. Fibronectin is a dimeric glycoprotein reported to be present during early tendon development (Hurle et al, 1989). In mice, the homozygous fibronectin mutant allele causes early embryonic lethality (George et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

Spatiotemporal protein distribution of TGF‐βs, their receptors, and extracellular matrix molecules during embryonic tendon development

Kuo

Petersen

Tuan

2008

Developmental Dynamics

109

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Tendon is one of the least understood tissues of the musculoskeletal system in terms of development and morphogenesis. Collagen fibrillogenesis has been the most studied aspect of tendon development, focusing largely on the role of matrix molecules such as collagen type III and decorin. While involvement of matrix molecules in collagen fibrillogenesis during chick tendon development is well understood, the role of growth factors has yet to be elucidated. This work examines the expression patterns of transforming growth factor (TGF) -␤1, -␤2, and -␤3, and their receptors with respect to expression patterns of collagen type III, decorin, and fibronectin. We focus on the intermediate stages of tendon development in the chick embryo, a period during which the tendon micro-and macro-architecture are being established. Our findings demonstrate for the first time that TGF-␤1, -␤2, and -␤3 have distinct spatiotemporal developmental protein localization patterns in the developing tendon and strongly suggest that these isoforms have independent roles in tendon development.

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Embryonic expression of tenascin‐X suggests a role in limb, muscle, and heart development

Burch

Bedolli

McDonough

et al. 1995

Developmental Dynamics

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Tenascin-X (TN-X) is the newest member of the tenascin family of extracellular matrix proteins and it is highly expressed in muscular tissues during development. To gain insight into the possible functions of TN-X during development, we evaluated its expression in the rat embryo. Using an 800 bp cDNA encoding the fibrinogen-like domain of TN-X, we show that TN-X expression begins in migrating cells of the epicardium in the El2 heart. The epicardium provides progenitors of fibrous and vascular tissue to the developing heart. After the epicardium is complete, TN-X is expressed in the sub-epicardial space in association with developing blood vessels, and later by non-myocytes dispersed through the myocardial wall. A similar pattern of TN-X expression, first in connective tissue surrounding muscle, and then by a subset of cells within muscle, was seen in para-axial, body wall, craniofacial, and appendicular muscle. This pattern suggests a role in connective tissue cell migration and late muscle morphogenesis. TN-X is also highly expressed in the interdigital space at El5 and surrounding developing tendons, suggesting an additional role in cell fate determination. Although the pattern of TN-X expression is distinct from that of tenascin C, they are frequently expressed in close proximity. Indirect genetic evidence in humans suggests an essential function for TN-X, and the pattern of TN-X expression in heart, skeletal muscle, and limb is consistent with this hypothesis.

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The extracellular matrix architecture relating to myotendinous pattern formation in the distal part of the developing chick limb: An ultrastructural, histochemical and immunocytochemical analysis

Cited by 51 publications

References 22 publications

Subectodermal microfibrillar bundles are organized into a distinct parallel array in the developing chick limb bud

Subectodermal microfibrillar bundles are organized into a distinct parallel array in the developing chick limb bud

Spatiotemporal protein distribution of TGF‐βs, their receptors, and extracellular matrix molecules during embryonic tendon development

Embryonic expression of tenascin‐X suggests a role in limb, muscle, and heart development

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