The extracellular current blocking effect of cesium chloride on the theta wave in the rabbit hippocampal CA1 region

Kitayama, Masaomi; Taguchi, Tomoe; Miyata, Harue; Matsuda, Yoshiki; Yamauchi, Takeshi; Kogure, Shinichi

doi:10.1016/s0304-3940(02)01067-4

Cited by 6 publications

(6 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The effects of DA on excitability and synaptic integration would thus differ between the two states, based in part on modulation of h-channels. A role for h-channels is also indicated in theta rhythmicity (Dickson et al, 2000a;Hu et al, 2002;Kitayama et al, 2002;Kocsis and Li, 2004). Theta rhythmicity, which may be generated in the EC (Alonso and Garcia-Austt, 1987;Schmitz et al, 1998;Kocsis et al, 1999), is hypothesized to influence memory formation and recall (Mizumori et al, 1990;O'Keefe, 1993;Buzsaki, 1996;Dickson et al, 2000b;Judge and Hasselmo, 2004).…”

Section: Discussionmentioning

confidence: 99%

Dopaminergic Regulation of Neuronal Excitability through Modulation ofI_hin Layer V Entorhinal Cortex

Rosenkranz¹,

Johnston²

2006

J. Neurosci.

View full text Add to dashboard Cite

The entorhinal cortex (EC) is a significant component of the systems that underlie certain forms of memory formation and recall. Evidence has been emerging that the dopaminergic system in the EC facilitates these and other functions of the EC. The effects of dopamine (DA) on membrane properties and excitability of EC neurons, however, are not known. We used in vitro whole-cell patchclamp recordings from layer V pyramidal neuronal somata and dendrites of the adult rat lateral EC to investigate the effects of DA on the excitability of these neurons. We found that brief application of DA caused a reduction in the excitability of layer V EC pyramidal neurons. This effect was attributable to voltage-dependent modification of membrane properties that can best be explained by an increase in a hyperpolarization-activated conductance. Furthermore, the effects of DA were blocked by pharmacological blockade of h-channels, but not by any of a number of other ion channels. These actions were produced by a D 1 receptor-mediated increase of cAMP but were independent of protein kinase A. A portion of the actions of DA can be attributed to effects in the apical dendrites. The data suggest that DA can directly influence the membrane properties of layer V EC pyramidal neurons by modulation of h-channels. These actions may underlie some of the effects of DA on memory formation.

show abstract

Section: Discussionmentioning

confidence: 99%

Dopaminergic Regulation of Neuronal Excitability through Modulation ofI_hin Layer V Entorhinal Cortex

Rosenkranz¹,

Johnston²

2006

J. Neurosci.

View full text Add to dashboard Cite

show abstract

“…2005). However, h‐channel blockers reduce epileptiform activity (Kitayama et al . 2002) and leave the frequency of neocortical oscillations produced by partial disinhibition unchanged (Castro‐Alamancos et al .…”

Section: Introductionmentioning

confidence: 99%

“…In the developing hippocampus, giant-depolarizing potentials (GDPs) are disrupted by ZD-7288 (Bender et al 2005). However, h-channel blockers reduce epileptiform activity (Kitayama et al 2002) and leave the frequency of neocortical oscillations produced by partial disinhibition unchanged (Castro-Alamancos et al 2007). The role of h-channels in the resonance of the membrane potential at θ-like frequency (range 3-12 Hz) has been demonstrated in CA1 (Hu et al 2002), L5 (Ulrich, 2002) pyramidal cells and in stellate cells of the entorhinal cortex (Dickson et al 2000;Haas et al 2007).…”

Section: Introductionmentioning

confidence: 99%

The role of hyperpolarization‐activated cationic current in spike‐time precision and intrinsic resonance in cortical neurons in vitro

Gastrein

Campanac

Gasselin

et al. 2011

The Journal of Physiology

View full text Add to dashboard Cite

Non-technical summary We determined here the role of the hyperpolarization-activated cationic (h) current on the temporal organization of hippocampal activity in vitro. In CA1 pyramidal neurons the h-current has three main actions. In addition to setting intrinsic resonance frequency at ∼4 Hz, the h-current determines, through two main mechanisms, the temporal precision of action potentials evoked by excitatory postsynaptic potentials or following stimulation of inhibitory postsynaptic potentials (rebound spiking). We propose that h-channels participate in the fine tuning of oscillatory activity in hippocampal and neocortical networks.Abstract Hyperpolarization-activated cyclic nucleotide modulated current (I h ) sets resonance frequency within the θ-range (5-12 Hz) in pyramidal neurons. However, its precise contribution to the temporal fidelity of spike generation in response to stimulation of excitatory or inhibitory synapses remains unclear. In conditions where pharmacological blockade of I h does not affect synaptic transmission, we show that postsynaptic h-channels improve spike time precision in CA1 pyramidal neurons through two main mechanisms. I h enhances precision of excitatory postsynaptic potential (EPSP)-spike coupling because I h reduces peak EPSP duration. I h improves the precision of rebound spiking following inhibitory postsynaptic potentials (IPSPs) in CA1 pyramidal neurons and sets pacemaker activity in stratum oriens interneurons because I h accelerates the decay of both IPSPs and after-hyperpolarizing potentials (AHPs). The contribution of h-channels to intrinsic resonance and EPSP waveform was comparatively much smaller in CA3 pyramidal neurons. Our results indicate that the elementary mechanisms by which postsynaptic h-channels control fidelity of spike timing at the scale of individual neurons may account for the decreased theta-activity observed in hippocampal and neocortical networks when h-channel activity is pharmacologically reduced.

show abstract

“…In vivo , the contribution of HCN channels to theta oscillations is more controversial. Although blocking HCN channels with cesium chloride in hippocampal CA1 attenuated theta power (Kitayama et al, ), theta activity was present in HCN1 knock‐out mice. The oscillation frequencies of theta modulated place cells, however, were reduced compared to wild‐type animals (Hussaini et al, ).…”

Section: Discussionmentioning

confidence: 99%

Phase precession of grid cells in a network model without external pacemaker

2013

View full text Add to dashboard Cite

Rodent brains encode space in both the firing rate and the spike timing of neurons in the medial entorhinal cortex. The rate code is realized by grid fields, that is, the neurons fire at multiple places that are arranged on a hexagonal lattice. Such activity is accompanied by theta oscillations of the local field potential. The phase of spikes thereby encodes space as well, since it decreases with the distance traveled in the field-a phenomenon called phase precession. A likely candidate for grid cells are entorhinal cortex stellate cells, which are type II oscillators and have been suggested to act as pacemakers. It is unclear how spiking of such putative pacemaker neurons would be able to precess in phase relative to a self-generated oscillation. This article presents a computational model of how this paradox can be resolved although the periodicity of the grid fields interferes with the periodic firing of the neurons. Our simulations show that the connections between stellate cells synchronize small cell groups, which allows a population oscillation during grid field activity that is accompanied by theta phase precession. Direct excitatory coupling between the stellate cells, indirect inhibitory coupling via a gamma-oscillating network of interneurons, or both could mediate this phase coordination. Our model further suggests modulation of h-currents to be a feasible mechanism to adjust phase precession to running-speed. The coexistence of rate and timing code for space hence follows as a natural consequence of the self-organization in a recurrent network.

show abstract

The extracellular current blocking effect of cesium chloride on the theta wave in the rabbit hippocampal CA1 region

Cited by 6 publications

References 20 publications

Dopaminergic Regulation of Neuronal Excitability through Modulation ofI_hin Layer V Entorhinal Cortex

Dopaminergic Regulation of Neuronal Excitability through Modulation ofI_hin Layer V Entorhinal Cortex

The role of hyperpolarization‐activated cationic current in spike‐time precision and intrinsic resonance in cortical neurons in vitro

Phase precession of grid cells in a network model without external pacemaker

Contact Info

Product

Resources

About

The extracellular current blocking effect of cesium chloride on the theta wave in the rabbit hippocampal CA1 region

Cited by 6 publications

References 20 publications

Dopaminergic Regulation of Neuronal Excitability through Modulation ofIhin Layer V Entorhinal Cortex

Dopaminergic Regulation of Neuronal Excitability through Modulation ofIhin Layer V Entorhinal Cortex

The role of hyperpolarization‐activated cationic current in spike‐time precision and intrinsic resonance in cortical neurons in vitro

Phase precession of grid cells in a network model without external pacemaker

Contact Info

Product

Resources

About

Dopaminergic Regulation of Neuronal Excitability through Modulation ofI_hin Layer V Entorhinal Cortex

Dopaminergic Regulation of Neuronal Excitability through Modulation ofI_hin Layer V Entorhinal Cortex