The Extent of Ossification of Posterior Longitudinal Ligament of the Spine Associated with Nucleotide Pyrophosphatase Gene and Leptin Receptor Gene Polymorphisms

Tahara, Masamichi; Aiba, Atsuomi; Yamazaki, Masashi; Ikeda, Yoshikazu; Goto, Sumio; Moriya, Hideshige; Okawa, Akihiko

doi:10.1097/01.brs.0000160686.18321.ad

Cited by 57 publications

(38 citation statements)

References 20 publications

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“…However, the results of gene analysis studies are not always consistent. Involvement of many growth factors and cytokines, including bone morphogenic protein 2 (BMP2) and transforming growth factor-β (TGF-β) has been demonstrated in various histochemical and cytochemical analyses 6,10,14) . Several transcription factors involved in cellular differentiation may also have a role 4) .…”

Section: Resultsmentioning

confidence: 99%

Association of Toll-Like Receptor 5 Gene Polymorphism with Susceptibility to Ossification of the Posterior Longitudinal Ligament of the Spine in Korean Population

Chung

Nam

et al. 2011

J Korean Neurosurg Soc

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Section: Resultsmentioning

confidence: 99%

Association of Toll-Like Receptor 5 Gene Polymorphism with Susceptibility to Ossification of the Posterior Longitudinal Ligament of the Spine in Korean Population

Chung

Nam

et al. 2011

J Korean Neurosurg Soc

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“…Some evidence suggests that NPPS gene mutation is associated with OPLL development. 65,91 In a later study by Tahara et al, 114 the authors showed that NPPS and leptin receptor genes do not promote an increased susceptibility to OPLL, but are associated with the extent of heterotopic ossification. Horikoshi et al…”

Section: Pathogenesismentioning

confidence: 99%

Ossification of the posterior longitudinal ligament: a review

Saetia

Cho

Lee

et al. 2011

FOC

120

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Ossification of the posterior longitudinal ligament (OPLL) is most commonly found in men, the elderly, and Asian patients. There are many diseases associated with OPLL, such as diffuse idiopathic skeletal hyperostosis, ankylosing spondylitis, and other spondyloarthropathies. Several factors have been reported to be associated with OPLL formation and progression, including genetic, hormonal, environmental, and lifestyle factors. However, the pathogenesis of OPLL is still unclear. Most symptomatic patients with OPLL present with neurological deficits such as myelopathy, radiculopathy, and/or bowel and bladder symptoms. There are some reports of asymptomatic OPLL. Both static and dynamic factors are related to the development of myelopathy. Plain radiography, CT, and MR imaging are used to evaluate OPLL extension and the area of spinal cord compression. Management of OPLL continues to be controversial. Each surgical technique has some advantages and disadvantages, and the choice of operation should be made case by case, depending on the patient's condition, level of pathology, type of OPLL, and the surgeon's experience. In this paper, the authors attempt to review the incidence, pathology, pathogenesis, natural history, clinical presentation, classification, radiological evaluation, and management of OPLL.

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“…Recent molecular genetic studies have identified several candidate genes that are differentially expressed in OPLL cells compared to normal ligament cells (15,16): reports suggest an increase in collagen, type VI, alpha 1 (Col6a1) (17,18); collagen type XI alpha 2 (Col11a2) (19,20); nucleotide pyrophosphatase (NPPS) (21 -24); leptin receptor (22); transforming growth factor-beta 1 (TGF-β1) (25 -27); promyelotic leukemia zinc finger (PLZF) (28,29); Tumor necrosis factor-alpha-stimulated gene 6 (TSG-6) (29); connective tissue growth factor (CTGF) (12); prostaglandin I 2 (PGI 2 ) (13) and endothelin-1 (30), amongst others. However, thus far, genetic factors have not been statistically linked to DISH or OPLL, most likely owing to the complexity of these diseases.…”

Section: Introductionmentioning

confidence: 99%

A Functional RNAi Screen for Runx2-Regulated Genes Associated With Ectopic Bone Formation in Human Spinal Ligaments

et al. 2008

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Abstract. Ossification of the posterior longitudinal ligament of the spine (OPLL) is characterized by ectopic ossification in the spinal ligaments, which enlarges with time and compresses the spinal cord, resulting in serious neurological symptoms. We previously reported that Runx2 expression was enhanced in spinal ligament cells from OPLL patients (OPLL cells). To clarify genes regulated by Runx2, Runx2 expression was first enhanced by culturing primary OPLL cells in osteogenic medium (OS induction) and then inhibited by siRNAs targeted to Runx2. DNA microarray demonstrated that in addition to chondrogenic factors such as connective tissue growth factor and cartilage oligomeric matrix protein, angiopoietin-1 was also significantly increased by OS induction and decreased by siRNAs for Runx2 in OPLL cells, suggesting that these genes are regulated by Runx2. However, these changes were not observed in non-OPLL control cells (from cervical spondylotic myelopathy patients). Furthermore, Runx2 was not decreased by siRNAs for angiopoietin-1. OS induction and RNAi inhibition of angiopoietin-1 expression was also observed in osteoblasts. Both siRNAs for Runx2 and angiopoietin-1 completely inhibited aggrecan-1 expression. These results suggest that angiopoietin-1 is downstream of Runx2 in both OPLL primary cells and osteoblasts. Angiopoietin-1 may play an important role in ectopic ossification.

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The Extent of Ossification of Posterior Longitudinal Ligament of the Spine Associated with Nucleotide Pyrophosphatase Gene and Leptin Receptor Gene Polymorphisms

Abstract: The present results suggest that the IVS20-11delT variant of the NPPS gene and the A861G variant of the leptin receptor gene are associated with more extensive OPLL, but not with the frequency with which it occurs.

Cited by 57 publications

References 20 publications

Association of Toll-Like Receptor 5 Gene Polymorphism with Susceptibility to Ossification of the Posterior Longitudinal Ligament of the Spine in Korean Population

Association of Toll-Like Receptor 5 Gene Polymorphism with Susceptibility to Ossification of the Posterior Longitudinal Ligament of the Spine in Korean Population

Ossification of the posterior longitudinal ligament: a review

A Functional RNAi Screen for Runx2-Regulated Genes Associated With Ectopic Bone Formation in Human Spinal Ligaments

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