The expression of thioredoxin-1 in preterm delivery placenta

Abstract

These results indicate that TRX-1 may be adaptively induced by the effects of inflammation and oxidative stress, suggesting protective roles for TRX-1 against these effects in the placenta of PTD.

Oxidative Stress and Preterm Birth: An Integrative Review

“…In one study that we reviewed, researchers reported higher TRX-1 mRNA and protein levels in PTB placental tissue compared to TB placental tissue, suggesting that dysregulation of the Trx system within the placenta may be associated with PTB (Song et al, 2012).…”

Hypoxic Status Is Associated With The Intensity Of Hypoxia Inducible Factor (Hif)-1α Expression In A Premature Placenta

“…This oxidative stress occurs in hypoxia circumstances. (Dong et al, 2012) Study by Dong et al found that there was a significantly increased HIF-1α mRNA level in premature placenta compared with term placenta. This increased expression of HIF-1α may be related to oxidative stress condition in the premature placenta.…”

“…In the development of early pregnancy, hypoxia condition is needed for the process of cytotrophoblasts invasion and infiltration into the decidua, to maintain the feto-maternal circulation.Therefore, HIF-1α will be expressed in the early trimester placenta and decreased with the increasing gestational age. (Dong et al, 2012;Rath et al, 2016)However, if the hypoxia continues until the final trimester, it can cause pain and even death for both mother and fetus. (Rath et al, 2016)Hypoxic placenta releases several mediators into the maternal circulation, one of which plays an important role is HIF-1α, a transcription factor for oxygen-dependent genes, to express proteins related to cell metabolism and angiogenesis.…”

“…This increased expression of HIF-1α may be related to oxidative stress condition in the premature placenta. (Dong et al, 2012) Study by Jellema et al has shown that inflammation of the cerebral tissue and mobilization of the peripheral innate immune system are in line with lesions and impaired function in the premature brain due to the state of global hypoxic ischemia. Further study related to cerebral involvement and systemic inflammatory processes due to global hypoxic ischemia is needed to discover a therapy of preterm infant encephalopathy.…”

“…(Ahumada- Barrios and Alvarado, 2016) Premature birth is closely related to infant morbidity and mortality. (Dong et al, 2012;Sulistiarini and Berliana, 2016) Premature babies will be at risk of developing health problems such as respiratory distress syndrome, retinopathy, breastfeeding disorders, necrotizing enterocolitis, infections, cerebral palsy, and can even cause infant death. (Gopagondanahalli et al, 2016) Premature birth can also cause milder disorders such as behavioral disorders, learning and language difficulties, attention disorders and hyperactivity, resulting in poor quality of human resources of future generations.…”