The Expression of Th1‐ and Th2‐Related Chemokine Receptors in Women with Recurrent Miscarriage: the Impact of Lymphocyte Immunotherapy

Kheshtchin, Nasim; Gharagozloo, Marjan; Andalib, Alireza; Ghahiri, Ataollah; Maracy, Mohammad Reza; Rezaei, Abbas

doi:10.1111/j.1600-0897.2010.00829.x

Cited by 46 publications

(39 citation statements)

References 35 publications

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“…24 Previously, we reported activated CD8 + T cells were inversely correlated with IFN-c/IL-10-producing CD3 + /4 + cell ratio in RPL women and suggested that CD3 + /CD8 + T cells may have an important role in maintenance of balanced Th1/Th2 cell ratios in women with reproductive failure. 24 Previously, we reported activated CD8 + T cells were inversely correlated with IFN-c/IL-10-producing CD3 + /4 + cell ratio in RPL women and suggested that CD3 + /CD8 + T cells may have an important role in maintenance of balanced Th1/Th2 cell ratios in women with reproductive failure.…”

Section: Discussionmentioning

confidence: 84%

Peripheral Blood NK Cell Cytotoxicities are Negatively Correlated with CD8⁺ T Cells in Fertile Women but not in Women with a History of Recurrent Pregnancy Loss

Yoo

Kwak‐Kim

Han

et al. 2012

American J Rep Immunol

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Section: Discussionmentioning

confidence: 84%

Peripheral Blood NK Cell Cytotoxicities are Negatively Correlated with CD8⁺ T Cells in Fertile Women but not in Women with a History of Recurrent Pregnancy Loss

Yoo

Kwak‐Kim

Han

et al. 2012

American J Rep Immunol

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“…The LIT possibly alters the proportions of NK and T cells 62 or the expression of T helper (Th)-1-and Th-2-related chemokine receptors 79 in favor of appropriate immune environment for embryo implantation (Figure 1). Deviation of Th1 toward Th2 cytokines is proposed to be the main mechanism underlying the benefit of LIT.…”

Section: Lit For Patients With Rplmentioning

confidence: 99%

Lymphocytes immunotherapy for preserving pregnancy: Mechanisms and Challenges

Taheri

Nejabati

Latifi

et al. 2018

American J Rep Immunol

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Due to the expression of paternal antigens by the embryo, pregnancy is considered as a semi-allograft and so immunological dysregulation is considered as one of the important causes in repeated implantation failure (RIF) and recurrent pregnancy loss (RPL). It has been revealed that lymphocytes immunotherapy (LIT) could be an appropriate approach to prevent pregnancy loss in such patients. Various mechanisms have been suggested for effectiveness of LIT such as enhancing expression of anti-paternal cytotoxic antibodies (APCA), progesterone-induced blocking factor (PIBF), anti-idiotypic antibodies (Ab2), and mixed lymphocyte reaction blocking antibodies (MLR-Bf), as well as reduction in the T helper 1/T helper 2 ratio and deviation in the pattern of cytokines production. However, there are controversial results about the beneficial effect of LIT treatment in RIF and RPL patients. In the current study, we reviewed findings of LIT in RIF and RPL patients with a focus on possible mechanisms of alloimmunization in preserving pregnancy. Besides, we highlighted possible reasons for mixed results about the effectiveness of LIT and way of solving the problem. Also, we proposed potential laboratory and clinical criteria to recruit patients for LIT.

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“…Type-1 T helper (Th1) and type-2 T helper (Th2) cells play important roles in immune responses, particularly in immune rejection and tolerance. 1,2 Hence, a method to achieve Th1/Th2 balance has been proposed to offset materno-fetal immune reactions during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

After 12 consecutive miscarriages, a patient received immunosuppressive treatment and delivered an intact baby

Nakagawa¹,

Kuroda

Sugiyama³

et al. 2017

Reprod Medicine & Biology

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AimAn immune etiology for idiopathic recurrent miscarriage is an important issue because a fetus is allogenetically different from the mother. Type 1 T helper (Th1) and Type 2 (Th2) cells have important functions in immune responses and there is a general agreement that pregnancy is associated with Th2 cell dominance. The purpose of this case report is to establish the effectiveness of an immunosuppressive treatment for a patient who had 11 consecutive miscarriages despite several treatments, such as anticoagulation, that showed elevated Th1/Th2 cell ratios.MethodsThis patient visited our clinic following 11 consecutive miscarriages between 2009 and 2014 that occurred between 5 and 8 weeks’ gestation. The Th1/Th2 cell ratio was evaluated after the 12th conception and she received an immunosuppressive treatment (tacrolimus; 1 mg/d).ResultsThe Th1/Th2 cell ratio was elevated after the 12th conception, but the patient miscarried, with a normal karyotype of chorionic villi despite the immunosuppressive treatment. After the 13th conception, she began receiving treatment with 2 mg/d of tacrolimus at 4 weeks’ gestation, which was continued until delivery.ConclusionFor recurrent miscarriage cases that show an elevated Th1/Th2 cell ratio after achieving pregnancy, immunosuppressive treatment with tacrolimus could be effective.

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The Expression of Th1‐ and Th2‐Related Chemokine Receptors in Women with Recurrent Miscarriage: the Impact of Lymphocyte Immunotherapy

Abstract: This study indicates the Th1 dominant immune responses in circulation of RM women compared to controls. Moreover, lymphocyte immunotherapy might influence pregnancy outcome via a shift in the balance of the Th1/Th2 chemokine receptors.

Cited by 46 publications

References 35 publications

Peripheral Blood NK Cell Cytotoxicities are Negatively Correlated with CD8⁺ T Cells in Fertile Women but not in Women with a History of Recurrent Pregnancy Loss

Peripheral Blood NK Cell Cytotoxicities are Negatively Correlated with CD8⁺ T Cells in Fertile Women but not in Women with a History of Recurrent Pregnancy Loss

Lymphocytes immunotherapy for preserving pregnancy: Mechanisms and Challenges

After 12 consecutive miscarriages, a patient received immunosuppressive treatment and delivered an intact baby

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The Expression of Th1‐ and Th2‐Related Chemokine Receptors in Women with Recurrent Miscarriage: the Impact of Lymphocyte Immunotherapy

Abstract: This study indicates the Th1 dominant immune responses in circulation of RM women compared to controls. Moreover, lymphocyte immunotherapy might influence pregnancy outcome via a shift in the balance of the Th1/Th2 chemokine receptors.

Cited by 46 publications

References 35 publications

Peripheral Blood NK Cell Cytotoxicities are Negatively Correlated with CD8+ T Cells in Fertile Women but not in Women with a History of Recurrent Pregnancy Loss

Peripheral Blood NK Cell Cytotoxicities are Negatively Correlated with CD8+ T Cells in Fertile Women but not in Women with a History of Recurrent Pregnancy Loss

Lymphocytes immunotherapy for preserving pregnancy: Mechanisms and Challenges

After 12 consecutive miscarriages, a patient received immunosuppressive treatment and delivered an intact baby

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Product

Resources

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Peripheral Blood NK Cell Cytotoxicities are Negatively Correlated with CD8⁺ T Cells in Fertile Women but not in Women with a History of Recurrent Pregnancy Loss

Peripheral Blood NK Cell Cytotoxicities are Negatively Correlated with CD8⁺ T Cells in Fertile Women but not in Women with a History of Recurrent Pregnancy Loss