The expression of succinate semialdehyde dehydrogenase in the caudal part of the spinal trigeminal nucleus is down-regulated after electrical stimulation of the dura mater surrounding the superior sagittal sinus in conscious rats

Wang, X.L.; Liang, Jingyao; Liu, R.Z.; Dong, Zhao; Yu, Songyan

doi:10.1016/j.neuroscience.2013.05.028

Cited by 4 publications

(2 citation statements)

References 50 publications

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“…To normalize the protein content, blots were probed with anti-GAPDH (1:1000, TA-08, ZSBIO, PRC). The densitometric values of the target protein of each group were normalized to their corresponding GAPDH (Wang et al 2013), and then expressed as a percentage of control group values.…”

Section: Western Blotmentioning

confidence: 99%

Role of proBDNF and BDNF in dendritic spine plasticity and depressive-like behaviors induced by an animal model of depression

Qiao

et al. 2017

Brain Research

111

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Major depressive disorder (MDD) is one of the most common psychiatric disorder, but the underlying mechanisms are largely unknown. Increasing evidence shows that brain-derived neurotrophic factor (BDNF) plays an important role in the structural plasticity induced by depression. Considering the opposite effects of BDNF and its precursor proBDNF on neural plasticity, we hypothesized that the balance of BDNF and proBDNF plays a critical role in chronic unpredicted mild stress (CUMS)-induced depressive-like behaviors and structural plasticity in the rodent hippocampus. The aims of this study were to compare the functions of BDNF and proBDNF in the CUMS-induced depressive-like behaviors, and determine the effects of BDNF and proBDNF on expressions of kalirin-7, postsynaptic density protein 95 (PSD95) and NMDA receptor subunit NR2B in the hippocampus of stressed and naïve control rats, respectively. Our results showed that CUMS induced depressive-like behaviors, caused a decrease in the ratio of BDNF/proBDNF in the hippocampus and resulted in a reduction in spine density in hippocampal CA1 pyramidal neurons; these alterations were accompanied by a decrease in the levels of kalirin-7, PSD95 and NR2B in the hippocampus. Injection of exogenous BDNF into the CA1 area of stressed rats reversed CUMS-induced depressive-like behaviors and prevented CUMS-induced spine loss and decrease in kalirin-7, NR2B and PSD95 levels. In contrast, injection of exogenous proBDNF into the CA1 region of naïve rats caused depressive-like behavior and an accompanying decrease in both spine density and the levels of kalirin-7, NR2B and PSD95. Taken together, our results suggest that the ratio of BDNF to proBDNF in the hippocampus plays a key role in CUMS-induced depressive-like behaviors and alterations of dendritic spines in hippocampal CA1 pyramidal neurons. Kalirin-7 may play an important role during this process.

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Section: Western Blotmentioning

confidence: 99%

Role of proBDNF and BDNF in dendritic spine plasticity and depressive-like behaviors induced by an animal model of depression

Qiao

et al. 2017

Brain Research

111

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“…Fos‐like immunoreactive neurons were found to be distributed in the caudal region of the spinal trigeminal and raphe magnus nuclei, and the activities of these neurons were inhibited by pretreatment intraperitoneal injection of rizatriptan benzoate . Succinate semialdehyde dehydrogenase was downregulated in the caudal region of the spinal trigeminal nucleus, suggesting that the γ‐aminobutyric acid concentration increased locally to modulate development of trigeminovascular headache . The relationship between migraine and depression has also been studied using this model.…”

Section: Developments In Headache Research In Chinamentioning

confidence: 99%

Headache Care in China

Zhang

Zhou

et al. 2014

Headache

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Headache disorders are problematic worldwide. China is no different. A population-based door-to-door survey revealed that the 1-year prevalence of primary headache disorders in China was 23.8%, constituting a major societal burden. Many headache centers and clinics have been established in China, and headache disorders (and associated stress) are receiving an increased level of expert attention. This review summarizes the outcomes of the epidemiological survey and the progress of clinical and basic research in China, describes the present situation in terms of headache diagnosis and treatment, and discusses the future of headache care in China.

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Progressive alterations of hippocampal CA3-CA1 synapses in an animal model of depression

Qiao

Ren

et al. 2014

Behavioural Brain Research

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The expression of succinate semialdehyde dehydrogenase in the caudal part of the spinal trigeminal nucleus is down-regulated after electrical stimulation of the dura mater surrounding the superior sagittal sinus in conscious rats

Cited by 4 publications

References 50 publications

Role of proBDNF and BDNF in dendritic spine plasticity and depressive-like behaviors induced by an animal model of depression

Role of proBDNF and BDNF in dendritic spine plasticity and depressive-like behaviors induced by an animal model of depression

Headache Care in China

Progressive alterations of hippocampal CA3-CA1 synapses in an animal model of depression

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