The expression of serotonin transporter protein correlates with the severity of psoriasis and chronic stress

Thorslund, Kristofer; Amatya, Beni; Dufva, Ann Eriksson; Nordlind, Klas

doi:10.1007/s00403-012-1303-8

Cited by 20 publications

(16 citation statements)

References 28 publications

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“…This observation was also accompanied by accumulation of sphinganine, palmitoyl sphingomyelin, and stearoyl sphingomyelin, with a sphingosine 1-phosphate decrease in the psoriasis group. In addition, the 3.9-fold increase in serotonin level may be of particular interest because expression of its transporter protein, SERT, is altered in psoriatic lesions, which may contribute to inflammatory processes in the skin (Thorslund et al., 2013).…”

Section: Resultsmentioning

confidence: 99%

Bioactive Lipid Mediator Profiles in Human Psoriasis Skin and Blood

Sorokin

Domenichiello

Dey

et al. 2018

Journal of Investigative Dermatology

102

113

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Psoriasis is a chronic immune-mediated disease that represents a unique model for investigating inflammation at local and systemic levels. Bioactive lipid mediators (LMs) are potent compounds reported to play a role in the development and resolution of inflammation. Currently, it is not known to what extent these LMs are involved in psoriasis pathophysiology and related metabolic dysfunction. Here, we use targeted and untargeted liquid chromatography-tandem mass spectrometry approaches to quantify LMs in skin and peripheral blood from psoriasis patients and compared them with those of healthy individuals. Lesional psoriasis skin was abundant in arachidonic acid metabolites, as 8-, 12- and 15-hydroxyeicosatetraenoic acid, compared with adjacent nonlesional and skin from healthy individuals. Additionally, a linoleic acid-derived LM, 13-hydroxyoctadecadienoic acid, was significantly increased compared with healthy skin (607.9 ng/g vs. 5.4 ng/g, P = 0.001). These psoriasis skin differences were accompanied by plasma decreases in antioxidant markers, including glutathione, and impaired lipolysis characterized by lower concentrations of primary and secondary bile acids. In conclusion, our study shows that psoriasis skin and blood have disease-specific phenotype profiles of bioactive LMs represented by omega-6 fatty acid-oxidized derivatives. These findings provide insights into psoriasis pathophysiology that could potentially contribute to new biomarkers and therapeutics.

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Section: Resultsmentioning

confidence: 99%

Bioactive Lipid Mediator Profiles in Human Psoriasis Skin and Blood

Sorokin

Domenichiello

Dey

et al. 2018

Journal of Investigative Dermatology

102

113

View full text Add to dashboard Cite

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“…Most of these reports have studied oral lichen planus, and the results are controversial [16][17][18][19][20][21][22][23][24][25] . Some recent immunohistochemical studies have shown that compared to normal skin, the expression of serotonin and its receptors in epithelial and adnexal structures was increased in the lesions of those with chronic inflammatory skin disease, including psoriasis, chronic eczema, allergic contact dermatitis, and atopic dermatitis 14,15,[26][27][28][29][30] . To our knowledge, our current study is the first to investigate serotonin expression in the lesions of LP.…”

Section: Discussionmentioning

confidence: 99%

Serotonin Expression in Lichen Planus Lesions and Its Relationship with Depression/Anxiety

et al. 2019

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Background: Psychological factors such as stress, depression, and anxiety have been documented to contribute to the development of lesions in lichen planus (LP). Objective: To evaluate the relationship between serotonin expression in LP lesions and depression/anxiety. Methods: Forty patients (22 females, 18 males) with LP and 20 healthy control subjects were included in this study. The severity of LP was assessed with the palmar method (using the measurement of affected body surface area [BSA]). The depression and anxiety scores were measured with Beck's depression inventory (BDI) and Beck's anxiety inventory (BAI). The expression of serotonin was determined via immunohistochemistry in LP lesions and in the control group skin using a monoclonal antibody to serotonin. Results: The skin biopsies of the LP patients had significantly higher levels of serotonin than those of the control subjects (p＜0.001). In the LP patients, and there was a positive correlation between serotonin expression and LP severity (p=0.022). Based on the results from the BDI and BAI, there was a significant relationship between the severity of depression/anxiety and intensity of serotonin expression (p ＜0.001). Conclusion: Data from this study suggest that serotonin may have a possible role in the pathogenesis of LP. Further, the relationship between serotonin expression in acute cutaneous lesions and the depression/anxiety scores indicates that serotonin may be a mediator for the association of LP and depression/anxiety simultaneously. There is a need for more specific studies showing the expression of serotonin in the lichen planus to demonstrate the cause or effect. (Ann Dermatol 31(2) 146∼153, 2019

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“…In fact, psoriatic patients achieving Ն75% improvement from baseline PASI score have a greater reduction in Zung Depression Scale score compared with patients achieving Ͻ75% improvement from baseline PASI score. A recent study conducted by Thorslund et al 75 showed a positive correlation (r ϭ 0.53; P Ͻ .05) between PASI and the numbers of serotonin transporter protein-positive dendritic cells in the epidermis of involved psoriatic skin. As such, it was suggested that the serotonergic system in the skin may be involved in the chronic inflammation of psoriatic skin.…”

Section: Potential Benefits Of Tnf-␣ Antagonists On Depressionmentioning

confidence: 89%

Tumor Necrosis Factor-α Triad: Psoriasis, Cardiovascular Disease, and Depression

et al. 2013

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Tumor necrosis factor-α (TNF-α) plays an intricate role in immune defense mechanisms. Over the past decades, studies have demonstrated that inflammatory cytokines, such as TNF-α and interleukin-6, may play an important role in the pathophysiology of psoriasis and depression. More recently, studies suggested an additional association of TNF-α with cardiovascular disease, which has attracted much attention. People with psoriasis, cardiovascular disease (i.e., heart failure or myocardial infarction [MI]), and depression have been found to have higher levels of proinflammatory cytokines, especially TNF-α. This article reviews the roles of TNF-α in psoriasis, cardiovascular disease, and depression.

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The expression of serotonin transporter protein correlates with the severity of psoriasis and chronic stress

Cited by 20 publications

References 28 publications

Bioactive Lipid Mediator Profiles in Human Psoriasis Skin and Blood

Bioactive Lipid Mediator Profiles in Human Psoriasis Skin and Blood

Serotonin Expression in Lichen Planus Lesions and Its Relationship with Depression/Anxiety

Tumor Necrosis Factor-α Triad: Psoriasis, Cardiovascular Disease, and Depression

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