The expression of murine cutaneous late phase reaction requires both IgE antibodies and CD4 T cells

Katsuhiko, S; Nagai, Hiroichi; Basaki, Yuji; Yamaya, Hidetoshi; Ikizawa, Koichi; Watanabe, Makoto; Kojima, M; Matsuura, Naosuke; Kiniwa, Mamoru

doi:10.1046/j.1365-2222.1997.d01-489.x

Cited by 13 publications

(19 citation statements)

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“…Our experiments using mast cell-deficient W/W v mice suggest that the biphasic cutaneous reactions are dependent on activation of mast cells, and it has been shown that antigen-specific IgE 20 and FceRI 24 are essential for development of the biphasic reactions as seen in this model, which indicates that findings in the W/W v mouse are relevant to the human IHR. Depletion of about 90% of circulating platelets in the mice significantly reduced the LPR, suggesting that platelets are important for leukocyte recruitment into skin.…”

Section: Discussionmentioning

confidence: 78%

“…20 Mice were sensitized by intraperitoneal injection of 3 mg ovalbumin (Sigma-Aldrich, St Louis, Mo) and 4 mg aluminum hydroxide gel. Reactions to ovalbumin were elicited by intracutaneous injection of 10 mg ovalbumin into the right ear of mice 2 weeks after sensitization, with an identical amount of vehicle injected into the left ear as a control.…”

Section: Immunizationmentioning

confidence: 99%

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Platelets play important roles in the late phase of the immediate hypersensitivity reaction

Tamagawa‐Mineoka

Katoh

Kishimoto

2009

Journal of Allergy and Clinical Immunology

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Section: Discussionmentioning

confidence: 78%

Section: Immunizationmentioning

confidence: 99%

Platelets play important roles in the late phase of the immediate hypersensitivity reaction

Tamagawa‐Mineoka

Katoh

Kishimoto

2009

Journal of Allergy and Clinical Immunology

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“…As described previously (Sawada et al, 1997;Cho et al, 2001;Pavlovic et al, 2008), mice were sensitized to ovalbumin (20 mg, grade VI, Sigma-Aldrich Chemie, Schnelldorf, Germany) on days 7 and 28 of the experimental protocol. AlD was induced by intradermal injection of ovalbumin (50 mg, grade V, Sigma-Aldrich Chemie) on day 35.…”

Section: The Ald-stress Modelmentioning

confidence: 99%

Nerve Growth Factor Partially Recovers Inflamed Skin from Stress-Induced Worsening in Allergic Inflammation

Peters

Liezmann

Spatz

et al. 2011

Journal of Investigative Dermatology

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Neuroimmune dysregulation characterizes atopic disease, but its nature and clinical impact remain ill-defined. Induced by stress, the neurotrophin nerve growth factor (NGF) may worsen cutaneous inflammation. We therefore studied the role of NGF in the cutaneous stress response in a mouse model for atopic dermatitis-like allergic dermatitis (AlD). Combining several methods, we found that stress increased cutaneous but not serum or hypothalamic NGF in telogen mice. Microarray analysis showed increased mRNAs of inflammatory and growth factors associated with NGF in the skin. In stress-worsened AlD, NGF-neutralizing antibodies markedly reduced epidermal thickening together with NGF, neurotrophin receptor (tyrosine kinase A and p75 neurotrophin receptor), and transforming growth factor-β expression by keratinocytes but did not alter transepidermal water loss. Moreover, NGF expression by mast cells was reduced; this corresponded to reduced cutaneous tumor necrosis factor-α (TNF-α) mRNA levels but not to changes in mast cell degranulation or in the T helper type 1 (Th1)/Th2 cytokine balance. Also, eosinophils expressed TNF receptor type 2, and we observed reduced eosinophil infiltration after treatment with NGF-neutralizing antibodies. We thus conclude that NGF acts as a local stress mediator in perceived stress and allergy and that increased NGF message contributes to worsening of cutaneous inflammation mainly by enhancing epidermal hyperplasia, pro-allergic cytokine induction, and allergy-characteristic cellular infiltration.

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“…These cytokines have been reported to be involved in eosinophil recruitment, suggesting that either CD4 T cells, mast cells, or both play a role in development of the antigen-induced LTR. The OVAinduced biphasic cutaneous reaction is well documented to show both the ITR and the LTR (33,34).…”

Section: Discussionmentioning

confidence: 99%

The Combined Effect of Topical CX-659S, a Novel Diaminouracil Derivative, With Topical Corticosteroid on the Three Types of Allergic Responses in Mice or Guinea Pigs

2003

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Abstract. CX-659S ((S)-6-amino-5-(6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxamido)-3-methyl-1-phenyl-2,4(1H,3H)-pyrimidinedione), a newly discovered anti-inflammatory compound, exerts inhibitory effects against picryl chloride-, oxazolone-, and dinitrochlorobenzeneinduced acute contact hypersensitivity responses (CHRs) characterized by Th1-type reactions. Furthermore, this compound suppressed chronic CHRs characterized by Th2-type reactions, which is well known to mimic many, if not all, events occurring within the lesional skin of patients with atopic dermatitis (AD). The present study was conducted to determine the combined effect of topical CX-659S with topical corticosteroid on immediate type (ITR), late type (LTR), and delayed type hypersensitivity (DTHR) allergic reactions that are involved in AD. An ineffective dose of CX-659S (0.03 mg / ear) combined with betamethasone valerate (BV) significantly potentiated inhibitory activity of BV alone (0.1 m g / ear and 0.3 m g / ear) on both the ITR and the LTR in mice with the ovalbumin (OVA)-induced biphasic cutaneous reaction. Furthermore, the combined effect of CX-659S with BV was also observed on dinitrochlorobenzene (DNCB)-induced DTHR in guinea pigs. These results indicate that CX-659S has a combined effect with corticosteroids on every ITR, LTR, and DTHR. Proper treatment with corticosteroids for a safe and effective treatment of AD is needed. Thus, the combination therapy of topical CX-659S with topical corticosteroid would be one of the potential approaches for devising a proper treatment with corticosteroids.

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The expression of murine cutaneous late phase reaction requires both IgE antibodies and CD4 T cells

Abstract: It is suggested that murine cutaneous LPR against OVA is a type 2 inflammatory response in which both IgE antibodies and CD4 T cells play an obligatory role.

Cited by 13 publications

References 0 publications

Platelets play important roles in the late phase of the immediate hypersensitivity reaction

Platelets play important roles in the late phase of the immediate hypersensitivity reaction

Nerve Growth Factor Partially Recovers Inflamed Skin from Stress-Induced Worsening in Allergic Inflammation

The Combined Effect of Topical CX-659S, a Novel Diaminouracil Derivative, With Topical Corticosteroid on the Three Types of Allergic Responses in Mice or Guinea Pigs

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