“…It is an advantage that the specimens of various types of body fluids can be applied, but the disadvantage is the cost of the instrument during operation, and requirement of large samples. Exosome sedimentation method (suitable for large samples, simple operation, but long cycle and low purity), immunoaffinity capture method (high purity, high cost, low yield), ExoQuick kits (the operation is simple and efficient but the use cost is high), ultrafiltration method (average purity and affected if blockage of the filter film) [39,80], has enormous potential but not yet developed a set of high efficiency, good specificity, low cost, and applicable to clinical standard protocols. The standard scheme is necessary to further explore the extraction solution of the exosome.…”