The expression of microRNAs and exposure to environmental contaminants related to human health: a review

Tumolo, Maria Rosaria; Panìco, Alessandra; Donno, Antonella De; Mincarone, Pierpaolo; Leo, Carlo Giacomo; Guarino, Roberto; Bagordo, Francesco; Serio, Francesca; Idolo, Adele; Grassi, Tiziana; Sabina, Saverio

doi:10.1080/09603123.2020.1757043

Cited by 45 publications

(27 citation statements)

References 99 publications

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“…According to the functional annotation of miR-124 and miR-506 target genes, our data indicated that microRNA- 124, microRNA-506 may be involved in immune-inflamrelated pathways such as JAK/STAT, NF-κB, mTOR, and TCR signaling pathway [40]. Furthermore, their common target proteins such as AKT3, GRB2, PK3R3, SOCS1, SOCS2, NRAS, SOCS3, TNF, PDPK1, RELA, and PLCG1 can simultaneously regulate multiple immune-inflammatory signaling pathways [41]. Taken together, the results suggest that the increased expression of serum exosomes miR-124 and miR-506 may be related to lead-induced inflammatory damage in the central nervous system, and the specific mechanism of its action needs further studying.…”

Section: Discussionmentioning

confidence: 77%

Statistical Analysis for Identifying Differentially MicroRNA in Serum Exosomes of Lead Workers

Shi

Wang

et al. 2020

Journal of Healthcare Engineering

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Exosomes can transmit central nervous system (CNS) information to the peripheral circulatory system through the brain barrier, and exosomes in the blood can also enter the central nervous system likewise. The components of exosomal contents play a pivotal role in cell signal communication, and thus, the transmission of exosomal content components is considered as a newly discovered method of long-distance communication between cells. The current is aimed to explore the changes of the exosomal microRNA group in the serum of lead-exposed workers, which might be involved in the lead-induced neuroinflammation, especially the activation of microglia and the release of inflammatory factors. We proposed a method combining statistical analysis and experiment according to the different expression of exosomal microRNA. Firstly, we divided workers into two groups, lead-exposed group and control group, and then questionnaires were used to obtain their basic information, and medical testing methods were used to obtain their serum exosomes. Secondly, principal component analysis was used to construct a comprehensive index of neurobehavioral function. Furthermore, volcano map and heatmap were used to display the differential gene distribution and correlation analysis of expression levels, respectively. Finally, two software applications, TargetScan and miRanda, were used to predict the target genes of the significantly different microRNAs, respectively, and the target genes predicted by the two software applications are screened according to the scoring standards of each software. Our results showed that 73 microRNAs were changed in the serum exosomes of lead-exposed worker, among which 48 microRNAs are upregulated and 25 microRNAs are downregulated. Moreover, the miR-124 and miR-506 were identified, and they might be involved in the process of lead-induced neuroinflammation.

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Section: Discussionmentioning

confidence: 77%

Statistical Analysis for Identifying Differentially MicroRNA in Serum Exosomes of Lead Workers

Shi

Wang

et al. 2020

Journal of Healthcare Engineering

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“…Moreover, in order to quantify individual exposures to specific environmental pollutants, further studies should examine also epigenetic alterations which determine changes in gene expression without altering DNA sequence [57]. These modifications, which include DNA methylation, histone modifications, and microRNAs (miRNAs) expression, operate together in a synergic manner, influencing genome expression patterns and functions in response to exogenous stimuli or exposure [58][59][60].…”

Section: Discussionmentioning

confidence: 99%

Early-Life Exposure to Environmental Air Pollution and Autism Spectrum Disorder: A Review of Available Evidence

Imbriani

Panìco

Grassi

et al. 2021

IJERPH

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The number of children diagnosed with Autism Spectrum Disorder (ASD) has rapidly increased globally. Genetic and environmental factors both contribute to the development of ASD. Several studies showed linkage between prenatal, early postnatal air pollution exposure and the risk of developing ASD. We reviewed the available literature concerning the relationship between early-life exposure to air pollutants and ASD onset in childhood. We searched on Medline and Scopus for cohort or case-control studies published in English from 1977 to 2020. A total of 20 articles were selected for the review. We found a strong association between maternal exposure to particulate matter (PM) during pregnancy or in the first years of the children’s life and the risk of the ASD. This association was found to be stronger with PM2.5 and less evident with the other pollutants. Current evidence suggest that pregnancy is the period in which exposure to environmental pollutants seems to be most impactful concerning the onset of ASD in children. Air pollution should be considered among the emerging risk factors for ASD. Further epidemiological and toxicological studies should address molecular pathways involved in the development of ASD and determine specific cause–effect associations.

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“…MiRNAs are short oligonucleotide sequences (20–24 nucleotides) evolutionarily conserved, consisting of single-stranded non-coding RNA molecules involved in post-transcriptional regulation of mRNAs [ 80 ].…”

Section: Mirna Response To Environmental Air Pollutants (Pms and Hmentioning

confidence: 99%

“…Recently, many studies have demonstrated miRNA-expression pattern changes in response to environmental cues [ 80 ]; this has increased interest in these molecules as new targets for environmental-based research [ 84 , 85 ]. These molecules fulfil key requirements for biomarkers and/or indicators of environmental-induced tissue injury as well as the mechanisms behind them.…”

Section: Mirna Response To Environmental Air Pollutants (Pms and Hmentioning

confidence: 99%

Micro-RNAs: Crossroads between the Exposure to Environmental Particulate Pollution and the Obstructive Pulmonary Disease

Finicelli

Squillaro

Galderisi

et al. 2020

IJMS

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Environmental pollution has reached a global echo and represents a serious problem for human health. Air pollution encompasses a set of hazardous substances, such as particulate matter and heavy metals (e.g., cadmium, lead, and arsenic), and has a strong impact on the environment by affecting groundwater, soil, and air. An adaptive response to environmental cues is essential for human survival, which is associated with the induction of adaptive phenotypes. The epigenetic mechanisms regulating the expression patterns of several genes are promising candidates to provide mechanistic and prognostic insights into this. Micro-RNAs (miRNAs) fulfil these features given their ability to respond to environmental factors and their critical role in determining phenotypes. These molecules are present in extracellular fluids, and their expression patterns are organ-, tissue-, or cell-specific. Moreover, the experimental settings for their quantitative and qualitative analysis are robust, standardized, and inexpensive. In this review, we provide an update on the role of miRNAs as suitable tools for understanding the mechanisms behind the physiopathological response to toxicants and the prognostic value of their expression pattern associable with specific exposures. We look at the mechanistic evidence associable to the role of miRNAs in the processes leading to environmental-induced pulmonary disease (i.e., chronic obstructive pulmonary disease).

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The expression of microRNAs and exposure to environmental contaminants related to human health: a review

Cited by 45 publications

References 99 publications

Statistical Analysis for Identifying Differentially MicroRNA in Serum Exosomes of Lead Workers

Statistical Analysis for Identifying Differentially MicroRNA in Serum Exosomes of Lead Workers

Early-Life Exposure to Environmental Air Pollution and Autism Spectrum Disorder: A Review of Available Evidence

Micro-RNAs: Crossroads between the Exposure to Environmental Particulate Pollution and the Obstructive Pulmonary Disease

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