2018
DOI: 10.1016/j.cyto.2018.04.030
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The expression of IL10RA in colorectal cancer and its correlation with the proliferation index and the clinical stage of the disease

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Cited by 22 publications
(19 citation statements)
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“…Moreover, the expression of IL10 in CRC tissues was significantly higher than the healthy intestinal endothelial cells. The correlation between the expression of IL10RA and the proliferation index or clinical stage of CRC confirms the importance of IL10RA in the pathogenesis of CRC (Zadka et al, 2018). In NK cell-based anticancer therapy, activation of autophagy in hypoxic cells operates through selective degradation of the pro-apoptotic NK-derived serine protease GZMB/granzyme B and by blocking the NK-mediated target cell apoptosis.…”
Section: Discussionmentioning
confidence: 55%
“…Moreover, the expression of IL10 in CRC tissues was significantly higher than the healthy intestinal endothelial cells. The correlation between the expression of IL10RA and the proliferation index or clinical stage of CRC confirms the importance of IL10RA in the pathogenesis of CRC (Zadka et al, 2018). In NK cell-based anticancer therapy, activation of autophagy in hypoxic cells operates through selective degradation of the pro-apoptotic NK-derived serine protease GZMB/granzyme B and by blocking the NK-mediated target cell apoptosis.…”
Section: Discussionmentioning
confidence: 55%
“…STAT3 regulates the inflammatory processes associated with the induction of metaplasia outbreaks, increases epithelial cell proliferation and appears to be responsible for the development and progression of some cancers [32]. In our previously published studies, the interleukin 10 receptor alpha subunit (IL10RA), IL-10 and phosphorylated STAT3 showed a statistically significant positive correlation with the cell proliferation antigen Ki67 in CRC [33], which seems to confirm the importance of Janus kinase and signal transducer and activation of transcription (JAK-STAT) signaling in the pathogenesis of some tumors ( Fig. 1A).…”
Section: The Most Common Inflammation-associated Risk Factors For Canmentioning
confidence: 92%
“…In oncological patients with CRC metastases to the liver who underwent surgical treatment, the postoperative range of CRP concentrations did not affect survival and was no good prognostic marker [246]. STAT3, which promotes cell proliferation of cancer cells, is one of the proteins that is activated in cellular signaling of immunosuppressive cytokines [33,247].…”
Section: Wound Healingmentioning
confidence: 99%
“…Interestingly, this miRNA might posttranscriptionally inhibit two tumor suppressor genes in CRC including IL10RA and AKR1B10. In 2018, Zadka et al reported that IL10RA is down-expressed in CRC tissues and shows negative correlation with the clinical stage and proliferation [21]. It is shown that AKR1B10 expression is significantly decreased in CRC samples and its down-expression correlates with decreased survival and poor prognosis of patients [22].…”
Section: Resultsmentioning
confidence: 99%