The expression of cytokeratin 19 in lymph nodes was a poor prognostic factor for hepatocellular carcinoma after hepatic resection

Lee, Chao‐Wei; Kuo, Wen-Ling; Yu, Ming–Chin; Chen, Tse–Ching; Tsai, Chia-Lung; Lee, Wei‐Chen; Chen, Miin‐Fu

doi:10.1186/1477-7819-11-136

Cited by 27 publications

(25 citation statements)

References 27 publications

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“…Tumor cells from HCC, as a result, should not express CK19 since they are supposed to originate from hepatocytes (16). However, previous studies also showed that about 10% of HCC with typical microscopic histologic features expressed CK19 (4,6). These CK19(+) HCC was found to behave more aggressively and had a worse outcome (4,(6)(7)(8)17).…”

Section: Discussionmentioning

confidence: 98%

“…However, previous studies also showed that about 10% of HCC with typical microscopic histologic features expressed CK19 (4,6). These CK19(+) HCC was found to behave more aggressively and had a worse outcome (4,(6)(7)(8)17). For example, Takano et al demonstrated that CK19(+) HCC exhibited higher invasiveness, metastatic potential, and poorer prognosis (17).…”

Section: Discussionmentioning

confidence: 99%

“…CHAO-WEI LEE [1][2][3] , SEY-EN LIN 4 , HSIN-I TSAI 2,3,5 , PO-JUNG SU 2,6,7 , CHIA-HSUN HSIEH 2,6 , YUNG-CHIA KUO 2,3,6 , CHANG-MU SUNG 2,3,8 , CHENG-YU LIN 8 , CHI-NEU TSAI 3 and MING-CHIN YU gene becomes silenced in healthy adult liver and stomach tissues. It functions as a peptide transporter and a cell adhesion molecule to maintain tissue integrity in epithelia (13).…”

Section: Cadherin 17 Is Related To Recurrence and Poor Prognosis Of Cmentioning

confidence: 99%

“…Studies have shown that the expression of CK19 in primary HCC is associated with poorer outcome (6). There have also been studies demonstrating that CK19 expression in primary HCC is a significant risk factor for developing lymph node metastasis (LNM) (4,7,8). Compared with other malignancies such as lung cancer, esophageal cancer, renal cancer, gastric cancer, and intra-hepatic cholangiocarcinoma, the incidence of LNM in primary HCC is low, and the prognosis is poor when LNM occurs (9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

“…Cytokeratin 19 (CK19) is a biliary epithelial cell marker and is generally expressed in intrahepatic cholangiocarcinoma (ICC) cells (4,5). Studies have shown that the expression of CK19 in primary HCC is associated with poorer outcome (6).…”

Section: Introductionmentioning

confidence: 99%

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Cadherin 17 is related to recurrence and poor prognosis of cytokeratin 19‑positive hepatocellular carcinoma

et al. 2017

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Abstract.A previous study demonstrated that cytokeratin 19 (CK19) expression in hepatocellular carcinoma (HCC) is an indicator of HCC invasiveness, including lymph node metastasis (LNM), tumor infiltration/non-encapsulation and poor prognosis. The exact mechanism by which CK19 expression results in poor prognosis remains unclear. Through the use of an Affymetrix U133A oligonucleotide microarray [20 patients with hepatitis B virus (HBV)-HCC], it was demonstrated that cadherin 17 (CDH17) significantly correlated with CK19 expression (R 2 , 0.867; P<0.001) in HBV-HCC. Immunohistochemical analysis (114 patients with HBV-HCC) also demonstrated a significant correlation between CK19 and CDH17 expressions in primary tumor tissue (R 2 , 0.414; P<0.001). In addition, CK19 and CDH17 expressions levels revealed a significant association with LNM (P<0.001). Cox regression multivariate analysis demonstrated that indocyanine green retention at 15 min >10% and CDH17 expression were independent prognostic factors for disease free survival (P=0.010 and 0.002, respectively). In vitro studies showed that epidermal growth factor can induce the expression of both CK19 and CDH17, and CDH17 in turn can enhance the expression of CK19 in HCC. In summary, this study demonstrated that the early recurrence and poor prognosis of CK19(+) HCC may be due to the expression of CDH17, a gene known to be associated with vascular invasion, tumor metastasis, and advanced tumor stage of HCC. Thus, novel therapeutics by targeting CDH17 may be beneficial for CK19(+) HCC.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Cadherin 17 Is Related To Recurrence and Poor Prognosis Of Cmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cadherin 17 is related to recurrence and poor prognosis of cytokeratin 19‑positive hepatocellular carcinoma

et al. 2017

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Preoperative Diagnosis of Dual‐Phenotype Hepatocellular Carcinoma Using Enhanced MRI Radiomics Models

Zhang

et al. 2022

Magnetic Resonance Imaging

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Background: Dual-phenotype hepatocellular carcinoma (DPHCC) is highly aggressive and difficult to distinguish from hepatocellular carcinoma (HCC). Purpose: To develop and validate clinical and radiomics models based on contrast-enhanced MRI for the preoperative diagnosis of DPHCC. Study type: Retrospective. Population: A total of 87 patients with DPHCC and 92 patients with non-DPHCC randomly divided into a training cohort (n = 125: 64 non-DPHCC; 61 DPHCC) and a validation cohort (n = 54: 28 non-DPHCC; 26 DPHCC). Field Strength/Sequence: A 3.0 T; dynamic contrast-enhanced MRI with time-resolved T1-weighted imaging sequence. Assessment: In the clinical model, the maximum tumor diameter and hepatitis B virus (HBV) were independent risk factors of DPHCC. In the radiomics model, a total of 1781 radiomics features were extracted from tumor volumes of interest (VOIs) in the arterial phase (AP) and portal venous phase (PP) images. For feature reduction and selection, Pearson correlation coefficient (PCC) and recursive feature elimination (RFE) were used. Clinical, AP, PP, and combined radiomics models were established using machine learning algorithms (support vector machine [SVM], logistic regression [LR], and logistic regression-least absolute shrinkage and selection operator [LR-LASSO]) and their discriminatory efficacy assessed and compared.Statistical Tests: The independent sample t test, Mann-Whitney U test, Chi-square test, regression analysis, receiver operating characteristic curve (ROC) analysis, Pearson correlation analysis, the Delong test. A P value < 0.05 was considered statistically significant. Results: In the validation cohort, the combined radiomics model (area under the curve [AUC] = 0.908, 95% confidence interval [CI]: 0.831-0.985) showed the highest diagnostic performance. The AUCs of the PP (AUC = 0.879, 95% CI: 0.779-0.979) and combined radiomics models were significantly higher than that of clinical model (AUC = 0.685, 95% CI: 0.526-0.844). There were no significant differences in AUC between AP or PP radiomics model and combined radiomics model (P = 0.286, 0.180 and 0.543). Conclusion: MRI radiomics models may be useful for discriminating DPHCC from non-DPHCC before surgery.

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Hepatocellular Carcinoma with Progenitor Cell Features

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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The expression of cytokeratin 19 in lymph nodes was a poor prognostic factor for hepatocellular carcinoma after hepatic resection

Cited by 27 publications

References 27 publications

Cadherin 17 is related to recurrence and poor prognosis of cytokeratin 19‑positive hepatocellular carcinoma

Cadherin 17 is related to recurrence and poor prognosis of cytokeratin 19‑positive hepatocellular carcinoma

Preoperative Diagnosis of Dual‐Phenotype Hepatocellular Carcinoma Using Enhanced MRI Radiomics Models

Hepatocellular Carcinoma with Progenitor Cell Features

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