The expression of aquaporins 1 and 9 in adult rat epididymis is perturbed by chronic exposure to ethanol

Teixeira, Giovana Rampazzo; Chuffa, Luiz Gustavo de Almeida; Martins, Otávio Augusto; Kremer, Rafael; Pinheiro, Patrícia Fernanda Felipe; Júnior, Wílson de Mello; Martinez, Marcelo; Martinez, Francisco Eduardo; Domeniconi, Raquel Fantin

doi:10.1016/j.tice.2011.11.001

Cited by 14 publications

(23 citation statements)

References 37 publications

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“…47 Another possible cause for decreased sperm count, sperm motility and increased abnormal sperm in higher dose treated rats was decreased availability of androgens (Fig. 50 It implies that any histological changes in the epididymis may affect the maturation of the sperm. Sperms leaving the testis are not physiologically mature, and such maturation occurs during their epididymal transit; after maturation, they become motile.…”

Section: Discussionmentioning

confidence: 99%

Subchronic cyanide toxicity on male reproductive system of albino rat

Shivanoor

David

2015

Toxicol. Res.

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Sexually mature albino rats were orally treated with sodium cyanide, NaCN (0, 0.64, 1.2 and 3.2 mg kg −1 BW) for 90 days. After 90 days of treatment, the rats were euthanized and male reproductive functions were assessed by histopathology, sperm head counts, sperm motility, sperm morphology and hormonal assay. Only a higher dose (3.2 mg kg −1 BW) of NaCN caused significant changes in body and reproductive organs weight, sperm motility, sperm count, sperm abnormality and in the levels of luteinizing hormone (LH), follicular stimulating hormone (FSH) and testosterone, whereas the group treated with 1.2 mg kg −1 BW showed significant changes in testis and prostate weight, sperm motility, sperm count, LH and testosterone levels. In contrast, insignificant changes were observed in body weight gain, reproductive organs weight, sperm parameters and hormonal levels in the rats treated with the lowest (0.64 mg kg −1 BW) dose of NaCN. Histopathologically, NaCN caused atrophy, degeneration in testis, increased number of clearing cells, vacuolation in epididymis and decreased secretion, and desquamations of glandular epithelium in the prostate were observed only at higher (1.2 and 3.2 mg kg −1 BW) dose levels compared to control.Whereas no changes in histology were observed in the rats treated with 0.64 mg kg −1 BW. Our results suggest that a high (3.2 mg kg −1 BW) dose of NaCN can exert reproductive toxicity in male Wistar albino rats.

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Section: Discussionmentioning

confidence: 99%

Subchronic cyanide toxicity on male reproductive system of albino rat

Shivanoor

David

2015

Toxicol. Res.

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“…Chrousos e Gold (1992) redefiniram estresse como o estado de desarmonia ou ameaça a homeostasia, promovendo adaptação fisiológica e comportamental, podendo ser especifica para um determinado estressor ou generalizada e inespecífica (TEIXEIRA et al ,2008).…”

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“…Situações rotineiras podem causar oscilações neuroendócrinas para manter a homeostasia, como presença ou não de alimentos, mudanças na postura e até mesmo falar em publico, nos humanos (TEIXEIRA et al ,2008).…”

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“…A duração do estímulo, mais que sua intensidade, é o que parece determinar seu impacto. Assim, estímulos prolongados geralmente são considerados negativos ("distress"), enquanto estímulos breves e que não se repetem, são considerados positivos ("arousal") (HERNÁNDEZ-JÁUREGUI et al,2005, KEAY et al, 2006, SCHERIFF et al, 2011RAMOS, 2012 (TEIXEIRA et al, 2008, SCHERIFF et al, 2011.…”

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“…A secreção destes neuropeptídeos, nos vasos porta-hipofisários, irá estimular a hipófise anterior, com a consequente liberação do hormônio adrenocorticotrófico (ACTH). Este, por sua vez, atua no córtex da glândula adrenal, estimulando a síntese e secreção de glicocorticoides, produto final do eixo HHA, como poderemos ver na figura 1 (GUYTON E HALL , TEIXEIRA et al, 2008, SCHERIFF et al, 2011. Em geral este evento pode levar de três a cinco minutos (SCHERIFF et al, 2011 (TIZART,2002, PARSLOW et al, 2004.…”

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Métodos de imunoensaio não radiométricos - enzimaimunoensaio (EIA) - e radiométricos - radioimunoensaio (RIA) - na avaliação dos metabólitos fecais de glicocorticoides em gatos domésticos que vivem sozinhos e em pequenas colônias

Fragoso¹

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Lower sperm quality and testicular and epididymal structural impairment in adult rats exposed to rosuvastatin during prepuberty

Leite

Sanabria

Cavariani

et al. 2018

J of Applied Toxicology

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The increase of obesity, bad eating habits and the lack of physical exercises are highly related to dyslipidemias. Rosuvastatin is a lipid-lowering drug and has been indicated to prevent cardiovascular diseases and to treat dyslipidemias due to its higher efficiency to reduce serum cholesterol concentrations. This study aimed to evaluate the reproductive adverse effects on sexual maturity due to rosuvastatin exposure in juvenile male rats during prepuberty. Three groups were randomly formed with newly weaned rats: control, whose rats received saline solution 0.9% and rosuvastatin at doses of 3 or 10 mg kg day , administered orally by gavage, from postnatal day 21 until preputial separation (average of 45 days for controls and 49 days for statin-treated animals), indicative of puberty onset. Male rats were maintained until sexual maturity and were killed on postnatal day 110. In the rosuvastatin-treated groups, the results showed diminished follicle-stimulating hormone, luteinizing hormone and testosterone concentrations, increased estradiol and prolactin concentrations, histopathologic alterations on testis and epididymis and decreased sperm quality. Moreover, statin-exposed groups showed decreased expression of androgen receptor on testis and epididymis and lower expression of aquaporin-9 on epididymal epithelium. In conclusion, administration of rosuvastatin to prepubertal male rats provoked long-term hormonal deregulation and impaired reproduction at adulthood.

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The expression of aquaporins 1 and 9 in adult rat epididymis is perturbed by chronic exposure to ethanol

Cited by 14 publications

References 37 publications

Subchronic cyanide toxicity on male reproductive system of albino rat

Subchronic cyanide toxicity on male reproductive system of albino rat

Métodos de imunoensaio não radiométricos - enzimaimunoensaio (EIA) - e radiométricos - radioimunoensaio (RIA) - na avaliação dos metabólitos fecais de glicocorticoides em gatos domésticos que vivem sozinhos e em pequenas colônias

Lower sperm quality and testicular and epididymal structural impairment in adult rats exposed to rosuvastatin during prepuberty

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