The Expression of a Human B‐Lymphocyte Antigen on Cells in Different Types of Leukaemia

Turesson, Ingemar; Berntorp, Erik; Zettervall, Olle

doi:10.1111/j.0954-6820.1979.tb13465.x

Cited by 4 publications

(2 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results in the present and in earlier studies (15,16) with the B-cell antigen 7420 and SmIg in lymphoma and CLL patients are consistent with a heterogeneity in differentiation of the malignant cells among different patients. We have also found a discrepant quantitative expression of these antigens in some patients, while in the normal healthy individual virtually all fluorescent lymphocytes express both 7420 antigen and SmIg.…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

High expression of lymphocyte surface immunoglobulin in chronic lymphocytic leukaemia may be a bad prognostic sign

Berntorp

Zettervall

1985

Scandinavian Journal of Haematology

Self Cite

View full text Add to dashboard Cite

Lymphocytes from 27 patients with B‐type chronic lymphocytic leukaemia (CLL) were tested with immunofluorescence for expression of surface membrane immunoglobulin (SmIg) and the B cell antigen 7420. When age at time of testing, sex, clinical stage according to Binet, disease progression according to Levin and percentage of SmIg and 7420 antigen‐expressing cells were used as explanatory variables for survival in a linear logistic regression model, only the SmIg variable was significant (p < 0.025). A high proportion of SmIg bearing cells (> 61%) was associated with short survival, large tumour mass and aggressive disease. The tentative conclusion is drawn that the differentiation stage of the tumour cells in CLL determines the clinical course of the disease and is inversely correlated to the SmIg expression.

show abstract

Section: Discussionsupporting

confidence: 91%

“…The direct immunofluorescence technique used was as described (15). The slides were examined in a Leitz Orthoplan fluorescence microscope equipped with epiillumination and filter systems for narrow band excitation of FITC and TRITC (22).…”

Section: Lmmunofluorescencementioning

confidence: 99%

High expression of lymphocyte surface immunoglobulin in chronic lymphocytic leukaemia may be a bad prognostic sign

Berntorp

Zettervall

1985

Scandinavian Journal of Haematology

Self Cite

View full text Add to dashboard Cite

show abstract

The Expression of a Human B‐Lymphocyte Antigen and Surface Membrane Immunoglobulin by Lymphoid cells from Patients with Lymphocytic Lymphoma, Multiple Myeloma and Benign Monoclonal Gammapathy

Turesson

Berntorp

Zettervall

1979

Journal of Internal Medicine

Self Cite

View full text Add to dashboard Cite

Lymphoid cells from patients with lymphocytic lymphoma, multiple myeloma or benign monoclonal gammapathy (BMG) were examined by direct immunofluorescence for the expression of surface membrane immunoglobulin (sIg) and B‐cell antigen defined by a rabbit antiserum against chronic lymphocytic leukaemia lymphocytes. This antiserum has been shown to detect a B‐cell antigen different from Ia‐like antigen. In well differentiated lymphocytic lymphoma, the cells carried the B‐cell antigen as well as one class of heavy and light Ig chain. A circulating monoclonal lymphocyte population was regularly found in the blood although the lymphocyte number was not increased. In multiple myeloma the number of circulating cells carrying mu chains was small, the depression being most pronounced in patients who had been treated with cytostatics. A monoclonal population of lymphocytes expressing the Ig isotype(s) of the M‐component was found in the blood in 6/15 cases and more often in patients with advanced disease. The number of cells with B‐cell antigen agreed fairly well with the number of Ig‐positive cells, indicating that the B‐cell antigen was expressed on normal as well as myeloma‐related lymphocytes. A dissociation of the expression of the antigens was however observed in two cases (one lymphocytic lymphoma, one myeloma) with a large number of cells with B‐cell antigen but a small number of cells with sIg. The B‐cell antigen was usually not detected on the surface membrane of Ig‐containing plasma cells from patients without monoclonal gammapathy or from the majority of patients with BMG but on a varying proportion of myeloma cells. The tentative conclusion is drawn that the B‐cell antigen is a differentiation antigen, which is gradually lost during B‐lymphocyte differentiation but is retained to some extent on myeloma cells as an expression of a lower degree of maturity.

show abstract

Cellular Expression of the Non‐HLA‐DR B‐Cell Antigen 7420: Studies on Non‐lymphoid Cells and on Lymphocytes from Different Species

1981

View full text Add to dashboard Cite

We recently reported on a heterologous antiserum (antiserum 7420), raised against chronic lymphocytic leukaemic lymphocytes, that reacts with B-lymphocyte antigen(s) different from known B-cell markers such as HLA-DR (Ia-like) antigens, surface immunoglobulin, and the Fc receptor. This antiserum is now shown to react also with a C3-receptor-positive population of lymphocytes from the dog, monkey, ox and sheep but not from rodents and avians. The antiserum does not react with the non-lymphoid human cells mature granulocytes, thrombocytes, erythrocytes, or spermatozoa, nor with the cultured cell lines tested, i.e. fibroblasts, melanoma cells, HeLa cells and green monkey kidney cells. This reactivity pattern differs somewhat from that reported for HLA-DR antiserum. The antigen(s) defined by the 7420 antiserum and the C3 receptor are different, since they redistribute independently on the lymphocyte surface.

show abstract

The Expression of a Human B‐Lymphocyte Antigen on Cells in Different Types of Leukaemia

Cited by 4 publications

References 34 publications

High expression of lymphocyte surface immunoglobulin in chronic lymphocytic leukaemia may be a bad prognostic sign

High expression of lymphocyte surface immunoglobulin in chronic lymphocytic leukaemia may be a bad prognostic sign

The Expression of a Human B‐Lymphocyte Antigen and Surface Membrane Immunoglobulin by Lymphoid cells from Patients with Lymphocytic Lymphoma, Multiple Myeloma and Benign Monoclonal Gammapathy

Cellular Expression of the Non‐HLA‐DR B‐Cell Antigen 7420: Studies on Non‐lymphoid Cells and on Lymphocytes from Different Species

Contact Info

Product

Resources

About