The expression levels of plasma dimethylglycine (DMG), human maternally expressed gene 3 (MEG3), and Apelin-12 in patients with acute myocardial infarction and their clinical significance

Abstract

Background:To analyze the expression levels of plasma dimethylglycine (DMG), human maternally expressed gene 3 (MEG3), and Apelin-12 in patients with acute myocardial infarction (AMI) and explore their clinical significance.Methods: One hundred and ten patients with suspected AMI (chest pain duration <6 h) who were admitted to our hospital between December 2018 and June 2020 were included. Plasma DMG, MEG3, and Apelin-12 levels were measured at the time of admission. The levels of plasma DMG, MEG3, and Apelin-12, as well as the general data and admission baseline data of these patients were then compared with those of non-AMI patients. The receiver operating characteristic (ROC) curve was used to analyze the clinical value of plasma DMG, MEG3, and Apelin-12 levels for the early diagnosis of AMI.Results: Among the 110 patients with chest pain suspected of AMI, 34 were clinically diagnosed with AMI, and 76 were non-AMI patients. The proportion of males, smoking, history of myocardial infarction, and congestive heart failure in the AMI group were higher than those of the non-AMI group. The proportions of systolic blood pressure (SBP), ST-segment elevation, and electrocardiogram (ECG) dynamic changes on admission were also higher in the AMI group compared to those of the non-AMI group (P<0.05). The plasma DMG, MEG3, and Apelin-12 levels of patients in the AMI group on admission were higher than those of the non-AMI group (P<0.05); all have diagnostic value for AMI upon admission. The area under the curve (AUC) of MEG3 was higher than that of both DMG and Apelin-12, however the difference was not statistically significant (Z=1.378, 0.934, P=0.168, 0.350). Using 0.015 as the cut-off value for MEG3messenger ribonucleic acid (mRNA), the sensitivity and specificity for diagnosing AMI were 85.29% and 81.58%, respectively.Conclusions: Our results showed that the plasma levels of DMG, MEG3, and Apelin-12 in patients with AMI were high, and thus, they can be used as biomarkers for the early diagnosis of AMI. Among them, MEG3 was the most effective in early diagnosing AMI.

The multifaceted biology of lncR-Meg3 in cardio-cerebrovascular diseases

“…The correlation between lncR-Meg3 and acute myocardial infarction was confirmed (Wei and Wang, 2021). The researchers measured the serum concentrations of dimethylglycine (DMG), Apelin-12, and lncR-Meg3 in 110 patients with acute chest pain for more than 6 h, Results showed that the levels of lncR-Meg3 in acute myocardial infarction (AMI) groups were approximately two times higher than those in healthy individuals.…”

Prognostic Value of Combining Apelin-12 and Estimated Glomerular Filtration Rate in Patients with ST-Segment Elevation Myocardial Infarction

“…Apelin-12, one of the most potent active forms of apelin, has been widely studied in the cardiovascular system. It has been reported that the plasma concentration of apelin-12 after acute myocardial infarction (AMI) is significantly lower than that in the control population [ 15 , 16 ]. Apelin-12 is negatively associated with troponin I levels, high-sensitivity C-reactive protein, neutrophil/lymphocyte ratio, and the rate of MACE, indicating that apelin-12 can serve as a prognostic biomarker for STEMI patients [ 9 , 17 ].…”

“…Our study showed that there was no correlation between apelin-12 and the degree of coronary artery stenosis indicated by the Gensini score. However, a study by Topuz suggested that apelin-12 was negatively correlated with the angiographic severity, as assessed according to the SYNTAX score [ 16 ]. This discrepancy may be due to the different sample sizes and methods used to assess the degree of coronary stenosis.…”

Serum Apelin-12 as a Novel Marker of Metabolic Inflammatory Syndrome in elderly Chinese

“…The exclusion criteria were any of the following: (1) type 1 diabetes, or diabetes induced by drugs or other endocrine disorders. (2) active infection or fever within two weeks before admission; (3) self-reported severe alcohol abuse; (4) autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, anaphylactoid purpura; (5) neuropathy or psychiatric diseases, such as multisystem atrophy, epilepsy, depression; (6) severe organ diseases; (7) tumors; (8) patients with incomplete clinical information or laboratory results.…”

“…Apelin-12 is one of the pharmacologically active apelin isoforms involved in various diseases such as intracranial atherosclerotic diseases [5], diabetes [6] and acute myocardial infarction [7]. Previous studies have demonstrated that serum apelin-12 was related to metabolic disorders.…”