The Expression Level of CD47 in Glioma and its Impact on Invasiveness

Abstract

Objective:To investigate the expression level of CD47 in glioma and assess its influence on the invasiveness of tumor cells. Methods: A total of 30 glioma brain tissue specimens and 10 normal brain tissue control specimens were selected. Real-time fluorescence quantitative PCR (RT-PCR), Western Blot analysis and invasion assay were used to analyze the effects of low and high expression levels of CD47 on the aggressiveness of glioma cells. Results: The expression of CD47 in glioma cells was found to be significantly high. Conversely, a notable decrease in CD47 expression resulted in a significant inhibition of tumor cell aggressiveness. On the other hand, an increased expression of CD47 was observed to significantly promote tumor cell aggressiveness (P<0.05). Conclusion: CD47 is highly expressed in glioma cells, and a decrease in CD47 expression of CD47 significantly inhibits the aggressiveness of tumor cells. CD47 serves as a significant prognostic factor and potential therapeutic target in glioma.