The expression and underlying angiogenesis effect of DPC4 and VEGF on the progression of cervical carcinoma

Yanni, Antoine; Liu, Ying; Song, Zhao

doi:10.3892/ol.2017.7580

Cited by 4 publications

(3 citation statements)

References 32 publications

(30 reference statements)

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“…When evaluating angiogenesis activity using antibodies to CD31, CD34, or CD105, correlations of MVD with cervical cancer prognosis were not revealed. In a study by Yani et al, the authors noted an increase in the level of VEGF and MVD in samples of squamous cell carcinoma compared with cervical inflammation and cervical intraepithelial neoplasia; however, there was no association of these markers with the stage of cervical cancer [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Morphological Characteristics and Clinical Significance of Different Types of Tumor Vessels in Patients with Stages I-IIA of Squamous Cervical Cancer

Сеньчукова

Макарова

Shurygina

et al. 2020

Journal of Oncology

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The determination of factors associated with progression of cervical cancer is important, both for a recurrence risk assessment and for determining optimal treatment tactics. Previously, we showed the prognostic value of different types of tumor microvessels (MVs) in gastric and breast cancer. The object of this research was to study the morphology and clinical significance of different tumor microvessels in early cervical cancer. A total of 65 archived paraffin blocks of patients with I-IIA stages of squamous cervical cancer were investigated. Samples were stained with Mayer hematoxylin and immunohistochemically using antibodies to CD34, podoplanin, HIF-1a, and Snail. The eight types of tumor MVs differed in morphology were identified. It was established that only the dilated capillaries (DСs) with weak expression of CD34, the contact type DCs, the capillaries in tumor solid component, and the lymphatic vessels in the lymphoid and polymorphic cell infiltrates of tumor stroma are associated with clinical and pathological characteristics of early cervical cancer. Preliminary results also suggest that a combination of fragmentation in tumor solid component and the contact type DCs may predict a recurrence of early cervical cancer. Given the small number of cervical cancer recurrences, the predictive significance of the described markers requires a more thorough examination.

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Section: Discussionmentioning

confidence: 99%

Morphological Characteristics and Clinical Significance of Different Types of Tumor Vessels in Patients with Stages I-IIA of Squamous Cervical Cancer

Сеньчукова

Макарова

Shurygina

et al. 2020

Journal of Oncology

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“…The data obtained during a study of the role of the deletion at locus 4 of pancreatic carcinoma (DPC4) and vascular endothelial growth factor (VEGF) in the development of cervical cancer suggest that the loss of DPC4 and overexpression of VEGF may play an important role in the progression of cervical carcinoma. In cervical cancer, high levels of VEGF expression were found in cervical cancer [69]. VEGF plays an important role in tumor progression by inducing angiogenesis, while as a potent inhibitor of neovascularization, TSP-1 can inhibit angiogenesis in cervical carcinoma.…”

Section: Markers Of Angiogenesis In Cervical Carcinogenesismentioning

confidence: 99%

“…A possible mechanism for tumor progression is the loss of DPC4, which induces angiogenesis by increasing VEGF expression. Apparently, VEGF is a target gene regulated by DPC4, and negative expression of TSP 1 promotes angiogenesis; however, further studies are needed to assess the correlation between DPC4 and TSP 1 [69]. During examination of 44 women with advanced cervical carcinoma, before the beginning of therapy a biopsy and a blood sample were taken from each patient, the density of micro vascularization was assessed in the biopsy material using antibodies to CD34, and the expression of angiogenic factors VEGFR, EGFR, and COX-2 was determined.…”

Section: Markers Of Angiogenesis In Cervical Carcinogenesismentioning

confidence: 99%

Cervical Carcinoma: Oncobiology and Biomarkers

Volkova

Pashov

Omelchuk

2021

IJMS

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Cervical cancer is one of the most common types of carcinomas causing morbidity and mortality in women in all countries of the world. At the moment, the oncology, oncobiology, and oncomorphology of cervical cancer are characterized by the accumulation of new information; various molecular biological, genetic, and immunohistochemical methods of investigation of the mechanisms of cervical carcinogenesis are tested and applied; targeted antitumour drugs and diagnostic, prognostic, and predictive biomarkers are being searched for. Many issues of the etiopathogenesis of cervical cancer have not been sufficiently studied, and the role of many biomarkers characterizing various stages of cervical carcinogenesis remains unclear. Therefore, the target of this review is to systematize and understand several problems in the pathogenesis of cervical cancer and to evaluate the significance and role of biomarkers in cervical carcinogenesis.

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Immunohistochemical Expression of Survivin and Vascular Endothelial Growth Factor in Cervical Squamous Cell Carcinoma

Gupta,

Diwaker,

Arora

et al. 2024

Indian J Surg Oncol

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The expression and underlying angiogenesis effect of DPC4 and VEGF on the progression of cervical carcinoma

Cited by 4 publications

References 32 publications

Morphological Characteristics and Clinical Significance of Different Types of Tumor Vessels in Patients with Stages I-IIA of Squamous Cervical Cancer

Morphological Characteristics and Clinical Significance of Different Types of Tumor Vessels in Patients with Stages I-IIA of Squamous Cervical Cancer

Cervical Carcinoma: Oncobiology and Biomarkers

Immunohistochemical Expression of Survivin and Vascular Endothelial Growth Factor in Cervical Squamous Cell Carcinoma

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