The expression and role of glycans at the feto-maternal interface in humans

Passaponti, Sofia; Pavone, Valentina; Cresti, Laura; Ietta, Francesca

doi:10.1016/j.tice.2021.101630

Cited by 12 publications

(6 citation statements)

References 42 publications

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“…Modifications of genital tract epithelia, mucus, and immune status occur throughout the menstrual cycle to accommodate conception and implantation 29 . At the time of conception, Sialyl Lewis X glycan epitopes on the human oocyte facilitates sperm-egg binding 57 , and glycans have also been implicated in the mediation of implantation 58 and immune homeostasis at the maternal–fetal interface 59 . Once implantation is successful, the cervicovaginal interface undergoes further modification, with the primary aim of forming a cervical barrier to infectious microbes to protect the developing fetus.…”

Section: Discussionmentioning

confidence: 99%

N-glycosylation of cervicovaginal fluid reflects microbial community, immune activity, and pregnancy status

Grassi

MacIntyre

et al. 2022

Sci Rep

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Human cervicovaginal fluid (CVF) is a complex, functionally important and glycan rich biological fluid, fundamental in mediating physiological events associated with reproductive health. Using a comprehensive glycomic strategy we reveal an extremely rich and complex N-glycome in CVF of pregnant and non-pregnant women, abundant in paucimannose and high mannose glycans, complex glycans with 2–4 N-Acetyllactosamine (LacNAc) antennae, and Poly-LacNAc glycans decorated with fucosylation and sialylation. N-glycosylation profiles were observed to differ in relation to pregnancy status, microbial composition, immune activation, and pregnancy outcome. Compared to CVF from women experiencing term birth, CVF from women who subsequently experienced preterm birth showed lower sialylation, which correlated to the presence of a diverse microbiome, and higher fucosylation, which correlated positively to pro-inflammatory cytokine concentration. This study is the first step towards better understanding the role of cervicovaginal glycans in reproductive health, their contribution to the mechanism of microbial driven preterm birth, and their potential for preventative therapy.

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Section: Discussionmentioning

confidence: 99%

N-glycosylation of cervicovaginal fluid reflects microbial community, immune activity, and pregnancy status

Grassi

MacIntyre

et al. 2022

Sci Rep

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“…Two major types of glycosylation, N‐glycosylation and O‐glycosylation, are linked to asparagine (N‐glycans) or the oxygen of serine or threonine (O‐glycans) [9] . N‐glycans consist of two N‐acetylglucosamines and three mannoses to form the “pentasaccharide core” [10] . N‐glycans are classified as high mannose (or oligomannosides), hybrids, and complexes by adding different monosaccharides to the “pentasaccharide core”, and the latter is further classified into bi‐antennae, tri‐antennae, and tetra‐antennae [11] .…”

Section: Common Types Of Glycosylationmentioning

confidence: 99%

“…[9] N-glycans consist of two N-acetylglucosamines and three mannoses to form the "pentasaccharide core". [10] N-glycans are classified as high mannose (or oligomannosides), hybrids, and complexes by adding different monosaccharides to the "pentasaccharide core", and the latter is further classified into bi-antennae, triantennae, and tetra-antennae. [11] No common precursor exists in O-glycans, and their biosynthesis is by the addition of monosaccharides.…”

Section: Common Types Of Glycosylationmentioning

confidence: 99%

Dessert or Poison? The Roles of Glycosylation in Alzheimer's, Parkinson's, Huntington's Disease, and Amyotrophic Lateral Sclerosis

Yang

Zhao

2023

ChemBioChem

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Ministry of Education and Key Laboratory of Neurons and glial cells of the central nervous system (CNS) are modified by glycosylation and rely on glycosylation to achieve normal neural function. Neurodegenerative disease is a common disease of the elderly, affecting their healthy life span and quality of life, and no effective treatment is currently available. Recent research implies that various glycosylation traits are altered during neurodegenerative diseases, suggesting a potential implication of glycosylation in disease pathology. Herein, we summarized the current knowledge about glycosylation associated with Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and Amyotrophic lateral sclerosis (ALS) pathogenesis, focusing on their promising functional avenues. Moreover, we collected research aimed at highlighting the need for such studies to provide a wealth of disease‐related glycosylation information that will help us better understand the pathophysiological mechanisms and hopefully specific glycosylation information to provide further diagnostic and therapeutic directions for neurodegenerative diseases.

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“…In this process, a variety of hormones, cytokines and adhesion molecules promote mutual recognition, localization and adhesion between the blastocyst and uterus. In addition to the endometrium, the blastocyst also has highly glycosylated proteins during embryo implantation [63]. It has been found that during hybridization between different species, embryo implantation is more successful if the blastocyst and the maternal endometrium have compatible glycans in the outer cell layer [61].…”

Section: Protein Glycosylation and Embryo Implantationmentioning

confidence: 99%

Protein glycosylation: bridging maternal–fetal crosstalk during embryo implantation

Sun,

Feng,

et al. 2023

Biology of Reproduction

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Infertility is a challenging health problem that affects 8% to 15% of couples worldwide. Establishing pregnancy requires successful embryo implantation, but about 85% of unsuccessful pregnancies are due to embryo implantation failure or loss soon after. Factors crucial for successful implantation include invasive blastocysts, receptive endometrium, invasion of trophoblast cells, and regulation of immune tolerance in the maternal-fetal interface. Maternal-fetal crosstalk, which relies heavily on protein–protein interactions, is a critical factor in implantation that involves multiple cellular communication and molecular pathways. Glycosylation, a protein modification process, is closely related to cell growth, adhesion, transport, signal transduction, and recognition. Protein glycosylation plays a crucial role in maternal-fetal crosstalk and can be divided into N-glycosylation and O-glycosylation, which are often terminated by sialylation or fucosylation. This review article examines the role of protein glycosylation in maternal-fetal crosstalk based on two transcriptome data from the GEO database (GSE139087 and GSE113790) and existing research, particularly in the context of the mechanism of protein glycosylation and embryo implantation. Dysregulation of protein glycosylation can lead to adverse pregnancy outcomes, such as missed abortion and recurrent spontaneous abortion (RSA), underscoring the importance of a thorough understanding of protein glycosylation in the diagnosis and treatment of female reproductive disorders. This knowledge could have significant clinical implications, leading to the development of more effective diagnostic and therapeutic approaches for these conditions.

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The expression and role of glycans at the feto-maternal interface in humans

Cited by 12 publications

References 42 publications

N-glycosylation of cervicovaginal fluid reflects microbial community, immune activity, and pregnancy status

N-glycosylation of cervicovaginal fluid reflects microbial community, immune activity, and pregnancy status

Dessert or Poison? The Roles of Glycosylation in Alzheimer's, Parkinson's, Huntington's Disease, and Amyotrophic Lateral Sclerosis

Protein glycosylation: bridging maternal–fetal crosstalk during embryo implantation

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