The expression and functional analysis of the sialyl-T antigen in prostate cancer

Bai, Ruifeng; Luan, Xue; Robbe-Masselot, Catherine; Brockhausen, Inka; Gao, Yin

doi:10.1007/s10719-020-09927-x

Cited by 21 publications

(18 citation statements)

References 36 publications

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“…Downregulation of ST3Gal-I reduces the tumor size in xenograft mouse model. [30] Comprehensive proteomic approaches of FUT8 overexpressing PCa cells.…”

Section: Glycosylationmentioning

confidence: 99%

“…The glycoproteomic approach to prostate cancer yielded several other publications (Table 1) that show the diversity of processes in prostate cancer that implicate glycosylation. [30]; cell adhesion [99]; N-linked glycans: in vitro proliferation, migration, invasion [101].…”

Section: Glycosylationmentioning

confidence: 99%

“…Current methods that are available do not offer satisfying solution to this issue. Therefore, glycans were suggested to be considered as a supplement to the current tools to diagnose prostate cancer rapidly, and to precisely determine tumor O-linked glycans: in vitro proliferation, migration, apoptosis; tumor size in mouse model [30]; cell adhesion [99];…”

Section: Fucosementioning

confidence: 99%

“…O-linked glycans: in vitro proliferation, migration, apoptosis; tumor size in mouse model [30]; cell adhesion [99]; N-linked glycans: in vitro proliferation, migration, invasion [101].…”

Section: Sialylationmentioning

confidence: 99%

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Post-Translational Modifications That Drive Prostate Cancer Progression

Samaržija

2021

Biomolecules

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While a protein primary structure is determined by genetic code, its specific functional form is mostly achieved in a dynamic interplay that includes actions of many enzymes involved in post-translational modifications. This versatile repertoire is widely used by cells to direct their response to external stimuli, regulate transcription and protein localization and to keep proteostasis. Herein, post-translational modifications with evident potency to drive prostate cancer are explored. A comprehensive list of proteome-wide and single protein post-translational modifications and their involvement in phenotypic outcomes is presented. Specifically, the data on phosphorylation, glycosylation, ubiquitination, SUMOylation, acetylation, and lipidation in prostate cancer and the enzymes involved are collected. This type of knowledge is especially valuable in cases when cancer cells do not differ in the expression or mutational status of a protein, but its differential activity is regulated on the level of post-translational modifications. Since their driving roles in prostate cancer, post-translational modifications are widely studied in attempts to advance prostate cancer treatment. Current strategies that exploit the potential of post-translational modifications in prostate cancer therapy are presented.

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“…Downregulation of ST3Gal-I reduces the tumor size in xenograft mouse model. [30] Comprehensive proteomic approaches of FUT8 overexpressing PCa cells.…”

Section: Glycosylationmentioning

confidence: 99%

Section: Glycosylationmentioning

confidence: 99%

Section: Fucosementioning

confidence: 99%

“…O-linked glycans: in vitro proliferation, migration, apoptosis; tumor size in mouse model [30]; cell adhesion [99]; N-linked glycans: in vitro proliferation, migration, invasion [101].…”

Section: Sialylationmentioning

confidence: 99%

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Post-Translational Modifications That Drive Prostate Cancer Progression

Samaržija

2021

Biomolecules

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“…Further research focused on examination of ST3Gal-I function in PC-3 cells; ST3Gal-I silencing studies indicated that ST3Gal-I is correlated with migration, proliferation and apoptosis of PC-3 cells. Subsequently, in vivo studies showed that decreased ST3Gal-I expression was associated with a reduction in tumor size in a xenograft mouse model, demonstrating that sialyl-T antigen could be considered as a biomarker for the prognosis of prostate cancer metastasis (Table 3) [124].…”

Section: Truncated O-glycansmentioning

confidence: 99%

Glycosylation: Rising Potential for Prostate Cancer Evaluation

Kałuża

Szczykutowicz

Ferens-Sieczkowska

2021

Cancers

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Prostate cancer is the second most commonly diagnosed cancer among men. Alterations in protein glycosylation are confirmed to be a reliable hallmark of cancer. Prostate-specific antigen is the biomarker that is used most frequently for prostate cancer detection, although its lack of sensitivity and specificity results in many unnecessary biopsies. A wide range of glycosylation alterations in prostate cancer cells, including increased sialylation and fucosylation, can modify protein function and play a crucial role in many important biological processes in cancer, including cell signalling, adhesion, migration, and cellular metabolism. In this review, we summarize studies evaluating the prostate cancer associated glycosylation related alterations in sialylation, mainly α2,3-sialylation, core fucosylation, branched N-glycans, LacdiNAc group and presence of truncated O-glycans (sTn, sT antigen). Finally, we discuss the great potential to make use of glycans as diagnostic and prognostic biomarkers for prostate cancer.

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Sialic acids in gynecological cancer development and progression: Impact on diagnosis and treatment

Berghuis

Pijnenborg

Boltje

et al. 2021

Intl Journal of Cancer

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Gynecological cancers are in the top 10 of most common cancers in women. Survival and outcome are strongly related to the stage at diagnosis. Therefore, early diagnosis is essential in reducing morbidity and mortality. The high mortality rate of gynecological cancers can mainly be attributed to ovarian cancer (OC). OC is commonly diagnosed at an advanced stage due to a lack of proper screening tools allowing early detection. Endometrial cancer (EC) on the contrary, is mostly diagnosed at an early stage and has, in general, better outcomes. The incidence of nonendometrioid EC has increased in the last decade, displaying a shared tumor biology with OC and consequently significantly worse outcome. New approaches allowing detection of gynecological cancers in an early stage are therefore desired. Recent studies on cancer biology have shown the relevance of altered glycosylation in the occurrence and progression of cancer. The aberrant expression of sialic acid, a specific carbohydrate terminating glycoproteins and glycolipids on the cell‐surface, is frequently correlated with malignancy. We aimed to determine the current understanding of sialic acid function in different gynecological cancers to identify the gaps in knowledge and its potential use for new diagnostic and therapeutic avenues. Therefore we performed a review on current literature focusing on studies where sialylation was linked to gynecological cancers. The identified studies showed elevated levels of sialic acid in serum, tissue and sialylated antigens in most patients with gynecological cancers, underlining its potential for diagnosis.

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The expression and functional analysis of the sialyl-T antigen in prostate cancer

Cited by 21 publications

References 36 publications

Post-Translational Modifications That Drive Prostate Cancer Progression

Post-Translational Modifications That Drive Prostate Cancer Progression

Glycosylation: Rising Potential for Prostate Cancer Evaluation

Sialic acids in gynecological cancer development and progression: Impact on diagnosis and treatment

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