The expression and function of the endothelin system in contractile properties of vaginal myofibroblasts of women with uterovaginal prolapse

Poncet, Sébastien; Meyer, Sara De; Richard, Christelle; Aubert, John‐David; Juillerat‐Jeanneret, Lucienne

doi:10.1016/j.ajog.2004.09.018

Cited by 39 publications

(33 citation statements)

References 22 publications

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“…Also, the function of supporting and contractile cells, the fibroblasts, may be disturbed [60]. However, data on the changes in collagen metabolism in patients with POP are conflicting.…”

Section: Discussionmentioning

confidence: 98%

“…functionality of the fibroblast, may also be important in the pathogenesis of POP. There is some indication that the contractibility of the vaginal (myo)fibroblasts is decreased in POP patients, which may result in deficient collagen [60]. In models of wound healing, skin myofibroblasts control the contractile and strength of the tissue, which is regulated by the so-called endothelin-1 (ET-1) system.…”

Section: The Fibroblast In Popmentioning

confidence: 99%

“…In models of wound healing, skin myofibroblasts control the contractile and strength of the tissue, which is regulated by the so-called endothelin-1 (ET-1) system. Poncet et al [60] compared cultures of α-smooth muscle actin-positive myofibroblasts that were established from POP patients to myofibroblasts from primiparous women with respect to their expression of the ET-1 system and contractile properties. They found that spontaneous contraction of myofibroblasts from estrogen-treated women with POP was significantly lower than from young primiparous women.…”

Section: The Fibroblast In Popmentioning

confidence: 99%

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Changes in connective tissue in patients with pelvic organ prolapse—a review of the current literature

2008

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Little is known about the pathophysiology of pelvic organ prolapse (POP). In 1996, Jackson presented a hypothesis on pelvic floor connective tissue that tried to explain the development of POP on a molecular level. The objective of this review is to test the hypothesis against recent literature. The method used was a review of literature. The association between POP and connective tissue metabolism is well established. However, the causality of this association is unclear. The characteristics of the pelvic floor connective tissue of POP patients relate to tissue repair. To resolve the question of cause and effect, the role of fibroblasts in producing the extracellular matrix should be clarified. With these data, the use of autologous or allogenic stem cells in the treatment of POP may come in sight. Recent literature supports the hypothesis of Jackson but does not resolve long-standing questions on the aetiology of POP.

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“…Also, the function of supporting and contractile cells, the fibroblasts, may be disturbed [60]. However, data on the changes in collagen metabolism in patients with POP are conflicting.…”

Section: Discussionmentioning

confidence: 98%

Section: The Fibroblast In Popmentioning

confidence: 99%

Section: The Fibroblast In Popmentioning

confidence: 99%

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Changes in connective tissue in patients with pelvic organ prolapse—a review of the current literature

2008

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“…23 Several studies have also demonstrated modified fibroblast responses in prolapse. [41][42][43][44] Several authors have analysed the expression of collagen regulators (MMP and TIMP) ( Table 2). Expression of MMP-1,-2 and -9 is increased in women with prolapse, demonstrating more collagen breakdown with loss of tissue integrity.…”

Section: Regulators Of Collagenmentioning

confidence: 99%

Recent studies of genetic dysfunction in pelvic organ prolapse: The role of collagen defects

Lim

Khoo

Wong

et al. 2014

Aust NZ J Obst Gynaeco

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Gynaecologists are becoming increasingly aware that women with a family history of prolapse are at an increased risk of prolapse refractory to treatment. In the past five years, several genetic mutations have been shown to correlate with increased prolapse susceptibility. These mutations can result in disordered collagen metabolism, which weaken the fascial support of the pelvic organs. This review examines the contemporary evidence regarding the role of collagen in prolapse.

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“…Cells were irradiated with a laser at 652 nm (Ceralas 652 laser diode, Biolitec, Jena, Germany) coupled to with a frontal diffuser (Medlight, Ecublens, Switzerland), at an irradiance of 30 mW/cm 2 and with light doses ranging from 2.5 to 20 J/ cm 2 as previously described [19,20,24,25]. Cell survival was assessed with the MTT assay 24 h after the end of the irradiation and compared with values for cells irradiated without the complexes as previously described [19].…”

Section: Photodynamic Therapymentioning

confidence: 99%

Sawhorse-type diruthenium tetracarbonyl complexes containing porphyrin-derived ligands as highly selective photosensitizers for female reproductive cancer cells

et al. 2009

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Diruthenium tetracarbonyl complexes of the type [Ru 2 (CO) 4 (l 2 -g 2 -O 2 CR) 2 L 2 ] containing a Ru-Ru backbone with four equatorial carbonyl ligands, two carboxylato bridges, and two axial two-electron ligands in a sawhorse-like geometry have been synthesized with porphyrin-derived substituents in the axial ligands The compounds demonstrated no cytotoxicity in the absence of laser irradiation but exhibited good phototoxicities in HeLa and A2780 cells when exposed to laser light at 652 nm, displaying an LD 50 between 1.5 and 6.5 J/cm 2 in these two cell lines and more than 15 J/cm 2 for the others. Thus, these types of porphyric compound present specificity for cancer cell lines of the female reproductive system and not for normal cells; thus being promising new organometallic photosensitizers.

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The expression and function of the endothelin system in contractile properties of vaginal myofibroblasts of women with uterovaginal prolapse

Cited by 39 publications

References 22 publications

Changes in connective tissue in patients with pelvic organ prolapse—a review of the current literature

Changes in connective tissue in patients with pelvic organ prolapse—a review of the current literature

Recent studies of genetic dysfunction in pelvic organ prolapse: The role of collagen defects

Sawhorse-type diruthenium tetracarbonyl complexes containing porphyrin-derived ligands as highly selective photosensitizers for female reproductive cancer cells

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