The Expressing Patterns of Opioid Peptides, Anti-opioid Peptides and Their Receptors in the Central Nervous System Are Involved in Electroacupuncture Tolerance in Goats

Wan, Juan; Qiu, Zhengying; Ding, Yi; Nan, Sha; Ding, Mingxing

doi:10.3389/fnins.2018.00902

Cited by 9 publications

(6 citation statements)

References 40 publications

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“…EA has been extensively used for treating various diseases (Liu et al, 2009; Shah et al, 2016; Cui et al, 2017b; Wan et al, 2018), especially pain disorders (Zeng et al, 2016; Hu et al, 2017; Wan et al, 2017). However, it also can provoke EAT, which is a negative effect for its application.…”

Section: Discussionmentioning

confidence: 99%

Thymosin Beta 4 Is Involved in the Development of Electroacupuncture Tolerance

Wan

Ding

Nan

et al. 2019

Front. Cell. Neurosci.

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Background: Electroacupuncture (EA) tolerance, a negative therapeutic effect, is a gradual decline in antinociception because of its repeated or prolonged use. This study aims to explore the role of thymosin beta 4 (Tβ4), having neuro-protection properties, in EA tolerance (EAT). Methods: Rats were treated with EA once daily for eight consecutive days to establish EAT, effect of Tβ4 on the development of EAT was determined through microinjection of Tβ4 antibody and siRNA into the cerebroventricle. The mRNA and protein expression profiles of Tβ4, opioid peptides (enkephalin, dynorphin and endorphin), and anti-opioid peptides (cholecystokinin octapeptide, CCK-8 and orphanin FQ, OFQ), and mu opioid receptor (MOR) and CCK B receptor (CCKBR) in the brain areas (hypothalamus, thalamus, cortex, midbrain and medulla) were characterized after Tβ4 siRNA was administered. Results: Tβ4 levels were increased at day 1, 4, and 8 and negatively correlated with the changes of tail flick latency in all areas. Tβ4 antibody and siRNA postponed EAT. Tβ4 siRNA caused decreased Tβ4 levels in all areas, which resulted in increased enkephalin, dynorphin, endorphin and MOR levels in most measured areas during repeated EA, but unchanged OFQ, CCK-8, and CCKBR levels in most measured areas. Tβ4 levels were negatively correlated with enkephalin, dynorphin, endorphin, or MOR levels in all areas except medulla, while positively correlated with OFQ and CCK-8 levels in some areas. Conclusion: These results confirmed Tβ4 facilitates EAT probably through negatively changing endogenous opioid peptides and their receptors and positively influencing anti-opioid peptides in the central nervous system.

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Section: Discussionmentioning

confidence: 99%

Thymosin Beta 4 Is Involved in the Development of Electroacupuncture Tolerance

Wan

Ding

Nan

et al. 2019

Front. Cell. Neurosci.

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“…EA stimulation releases endogenous opioids for active pain management [17,18]. The receptors are also involved in pain regulation [19]. The endogenous opioid mechanism is the most well-known neuronal mechanism of analgesia.…”

Section: Opioid Peptidesmentioning

confidence: 99%

Molecular mechanism of electroacupuncture for improving perioperative complications with the guidance of enhanced recovery after surgery

Mao

Yang

2023

Exploration of Medicine

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Enhanced recovery after surgery (ERAS) is a recommended surgical strategy at present, the core content is to reduce perioperative stress response and postoperative complications through perioperative multi-mode analgesia and intensive surgery. Electroacupuncture (EA) has been widely used in various clinical applications, and its efficacy and safety have been fully proven. The application of acupuncture in ERAS will have an important impact on rehabilitation research and development. In this review, the molecular mechanism of EA in ERAS are summed up from promoting perioperative efficacy to improving postoperative immune status. The combination of EA and ERAS may better promote the recovery of patients and the development of rehabilitation.

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“…EA stimulation can release endogenous opioid peptides for positive pain management [ 5 , 17 ]. Their receptors are similarly involved in pain mechanism modulation [ 62 ]. The endogenous opioid mechanism is the most well-recognized neuronal mechanism of acupuncture analgesia.…”

Section: Mechanism Of Neurotransmitters In Acupuncture Analgesiamentioning

confidence: 99%

Effective Oriental Magic for Analgesia: Acupuncture

Zhang

Shi

Deng

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Pain is a kind of complex physiological and psychological symptom, which makes the person debilitated and uncomfortable. Some persistent pain is unbearable for the patients, reducing the quality of life and bringing considerable pressure to the individuals and society. Pain killers seem to be effective in analgesia for patients, but their safety and addiction are crucial issues. From the theory of traditional Chinese medicine (TCM), the blocked meridian is the main cause of pain, and effective acupuncture can play a positive analgesic effect. Acupuncture that can date back thousands of years is one of the ancient medical practices in China. Its safety and effectiveness are respected. Based on its superior safety and inferior side effects, it has been gradually recognized as a therapeutic intervention method for complementary medicine, which is also generally used to treat multiple pain diseases. It is shown by modern medical studies that neurotransmitters are the material basis for the acupuncture effect, and the effect of acupuncture analgesia is related to changes in neurotransmitters. However, the specific mechanism has not been elucidated. This review aims to comprehensively discuss the historical evolution of acupuncture analgesia, clinical research of acupuncture analgesia, comparison of acupuncture and drug therapy, the neurotransmitter mechanism of acupuncture analgesia, the effect of acupuncture manipulation on analgesia, and bibliometric analysis of acupuncture treatment for pain, to explore the superiority and related mechanism of acupuncture analgesia from different aspects, and to provide a more effective treatment for alleviating patients’ pain.

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The Expressing Patterns of Opioid Peptides, Anti-opioid Peptides and Their Receptors in the Central Nervous System Are Involved in Electroacupuncture Tolerance in Goats

Cited by 9 publications

References 40 publications

Thymosin Beta 4 Is Involved in the Development of Electroacupuncture Tolerance

Thymosin Beta 4 Is Involved in the Development of Electroacupuncture Tolerance

Molecular mechanism of electroacupuncture for improving perioperative complications with the guidance of enhanced recovery after surgery

Effective Oriental Magic for Analgesia: Acupuncture

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