The exposure levels and health risk assessment of antibiotics in urine and its association with platelet mitochondrial DNA methylation in adults from Tianjin, China: A preliminary study

Zhang, Jing; Liu, Ziquan; Song, Shanjun; Fang, Junkai; Wang, Lei; Zhao, Liwei; Li, Chenguang; Li, Weixia; Byun, Hyang-Min; Guo, Liqiong; Li, Penghui

doi:10.1016/j.ecoenv.2022.113204

Cited by 13 publications

(7 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The treated samples were run on 0.8% agarose gel and visualized under UV light. Finally, the rate of mtDNA methylation was tested by the PyroMark Q48 autoprep pyrophosphate sequencer (QIAGEN, Hilden, Germany) ( 26 ).…”

Section: Methodsmentioning

confidence: 99%

“…Two samples with known global DNA methylation levels, namely, low (1%) and high (99%), were added as positive controls in pyrophosphate sequencing. Finally, two duplicate pyrosequencing analyses were performed for each DNA sequence ( 26 ).…”

Section: Methodsmentioning

confidence: 99%

“…In this study, we recruited 39 men (aged 27-43 years, referred by a physician) from Project ELEFANT (26,(31)(32)(33)(34)(35). At recruitment, all participants excluded autoimmune diseases, cardiovascular diseases, severe liver diseases, thyroid diseases, and blood diseases, and completed a physical examination under the guidance of nurses, signed an informed consent form, and filled in basic information (including age and BMI) listed in Table 1.…”

Section: Study Populationmentioning

confidence: 99%

“…Over the years, methylation in mitochondrial DNA ( mtDNA ) has drawn attention. As mtDNA lacks a protector protein and effective repair mechanism, it is more vulnerable to reactive oxygen species (ROS) and mutations than nuclear DNA ( 24 – 26 ). An ENVIRONAGE birth cohort study suggested that mtDNA reacts to particulate matter that leads to ROS ( 27 ).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Phthalates and phthalate metabolites in urine from Tianjin and implications for platelet mitochondrial DNA methylation

Guo

Fang

et al. 2023

Front. Public Health

Self Cite

View full text Add to dashboard Cite

BackgroundPhthalates (PAEs) are important synthetic substances in plastics, attracting much attention due to their potential effects on the cardiovascular system.MethodsIn this study, urine and blood samples from 39 individuals were collected in Tianjin, China. Phthalates and phthalate metabolites (mPAEs) were analyzed using gas chromatography-mass spectrometry (GC-MS) and high-performance liquid chromatography-mass spectrometry (HPLC-MS), respectively. The polymerase chain reaction (PCR) products from bisulfite-treated mitochondrial DNA (mtDNA) samples were analyzed using pyrosequencing technology.ResultsThe detection frequencies for 9 PAEs varied from 2.56 to 92.31%, and those for 10 mPAEs varied from 30.77 to 100%. The estimated daily intakes (EDIs) and cumulative risk of PAEs were calculated based on the experimental statistics of urinary PAEs and mPAEs. For PAEs, the HIRfD (hazard index corresponding to reference doses) values of 10.26% of participants and the HITDI (hazard index corresponding to tolerable daily intake) values of 30.77% of participants were estimated to exceed 1, suggesting a relatively high exposure risk. The mtDNA methylation levels in the MT-ATP8 and MT-ND5 were observed to be lower than in the MT-ATP6. Mono-ethyl phthalate (MEP) and MT-ATP8 were positively correlated with triglyceride levels (p < 0.05). Based on the association of PAEs, mtDNA methylation, and triglycerides, the mediating role of mtDNA methylation between PAEs and cardiovascular diseases (CVDs) was analyzed in this study, but no mediated effect was observed.ConclusionThe effects of PAE exposure on cardiovascular diseases (CVDs) should be investigated further.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Study Populationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Phthalates and phthalate metabolites in urine from Tianjin and implications for platelet mitochondrial DNA methylation

Guo

Fang

et al. 2023

Front. Public Health

Self Cite

View full text Add to dashboard Cite

show abstract

“…Unfortunately, some freshwater rivers and lakes have been contaminated by various antibiotics, such as norfloxacin, ofloxacin, erythromycin, roerythromycin, enfloxacin, and sulfamazine 58 , 59 . Antibiotic pollution in lakes and rivers have become a global public concern due to their negative impact on the ecological environment and human health, especially about the antibiotic resistance problems 60 .…”

Section: Resultsmentioning

confidence: 99%

Carbon fiber coated by quinoa cellulose nanosheet with outstanding scaled salt self-cleaning performance and purification of organic and antibiotic contaminated water

Yang

Suo

Zhao

et al. 2022

Sci Rep

View full text Add to dashboard Cite

To date, various solar driven evaporation technologies have been developed for treatment of seawater and wastewater but with the threat from salt polluted and single treatment of seawater. Herein, we develop a multifunctional evaporator constructed by carbon fiber coated by quinoa cellulose nanosheet (CFQC) with outstanding self-cleaning performance and good purification property for treatment of organic and antibiotic polluted water. The resulting Zn-CFQC exhibits good light to thermal performance which can absorb about 86.95% lights in the range of UV–Vis–NIR (200–2500 nm); therefore, the wet and dry surface temperatures of Zn-CFQC are held at 62.1 and 124.3 °C respectively, and keep a speed of 3.2 kg m−2 h−1 for water evaporating under 1000 W m−2 illumination. Such good light-to-thermal capabilities can be mainly imputed to the unique surface microstructures of the carbon fiber which decorated by two-dimension cellulose and activated by ZnCl2. Additionally, Zn-CFQC shows good salt automatic-cleaning capability at night and corresponding mechanism has been simply elucidated according to the chemical potential theory. The method of treatment of carbon fiber opens a new way for commercial carbon fiber utilization of solar assisted water purification.

show abstract

Antibiotic exposure associated with nighttime sleep duration and daytime sleepiness in newlyweds

Gu,

Ni,

Wang

et al. 2023

Environ Sci Pollut Res

View full text Add to dashboard Cite

The exposure levels and health risk assessment of antibiotics in urine and its association with platelet mitochondrial DNA methylation in adults from Tianjin, China: A preliminary study

Cited by 13 publications

References 69 publications

Phthalates and phthalate metabolites in urine from Tianjin and implications for platelet mitochondrial DNA methylation

Phthalates and phthalate metabolites in urine from Tianjin and implications for platelet mitochondrial DNA methylation

Carbon fiber coated by quinoa cellulose nanosheet with outstanding scaled salt self-cleaning performance and purification of organic and antibiotic contaminated water

Antibiotic exposure associated with nighttime sleep duration and daytime sleepiness in newlyweds

Contact Info

Product

Resources

About