The exposome and liver disease - how environmental factors affect liver health

Barouki, Robert; Samson, Michel; Blanc, Étienne; Colombo, Massimo; Zucman–Rossi, Jessica; Lazaridis, Konstantinos N.; Miller, Gary W.; Coumoul, Xavier

doi:10.1016/j.jhep.2023.02.034

Cited by 35 publications

(21 citation statements)

References 134 publications

(149 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Liver fibrosis, which results from chronic damage to the liver, is a characteristic of many chronic liver diseases (Bataller and Brenner, 2005). Previously, exposome-based studies had found a significant association between environmental chemicals such as B[a]P and different liver diseases (Barouki et al, 2023; Cheung et al, 2020). Here, we observed an emergent B[a]P-induced toxicity pathway originating from MIE ‘Activation, AhR’ (KE:18) and terminating at AO ‘N/A, Liver fibrosis’ (KE:344).…”

Section: Resultsmentioning

confidence: 99%

Leveraging integrative toxicogenomic approach towards development of stressor-centric adverse outcome pathway networks for plastic additives

Sahoo,

Chivukula,

Madgaonkar

et al. 2024

Preprint

View full text Add to dashboard Cite

Plastics are widespread pollutants found in atmospheric, terrestrial and aquatic ecosystems due to their extensive usage and environmental persistence. Plastic additives, that are utilized to achieve specific functionality in plastics, leach into the environment upon plastic degradation and pose considerable risk to ecological and human health. Limited knowledge concerning the presence of plastic additives throughout the plastic life cycle has hindered their effective regulation, thereby posing risks to product safety. In this study, we leveraged the adverse outcome pathway (AOP) framework to understand the mechanisms underlying plastic additives-induced toxicities. We first identified an exhaustive list of 6470 plastic additives from chemicals documented to be found in plastics. Next, we leveraged heterogenous toxicogenomics and biological endpoints data from five exposome-relevant resources, and identified associations between 1287 plastic additives and 322 complete and high quality AOPs within AOP-Wiki. Based on these plastic additive-AOP associations, we constructed a stressor-centric AOP network, wherein the stressors are categorized into 10 priority use sectors and AOPs are linked to 27 disease categories. We visualized the plastic additives-AOP network for each of the 1287 plastic additives and made them available in a dedicated website: https://cb.imsc.res.in/saopadditives/. Finally, we showed the utility of the constructed plastic additives-AOP network by identifying 28 highly relevant AOPs associated with benzo[a]pyrene, and thereafter, explored the associated toxicity pathways leading to respiratory and gastrointestinal system diseases in humans and developmental disorders in aquatic species. Overall, the constructed plastic additives-AOP network will enable regulatory risk assessment of plastic additives, thereby contributing towards a toxic-free circular economy for plastics.

show abstract

Section: Resultsmentioning

confidence: 99%

Leveraging integrative toxicogenomic approach towards development of stressor-centric adverse outcome pathway networks for plastic additives

Sahoo,

Chivukula,

Madgaonkar

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Se control is crucial for maintaining homeostasis through transport networks and feedback loops. [29]. Neurological symptoms include deteriorating voluntary movement coordination, hallucinations, Parkinsonism, and multiple sclerosis [30].…”

Section: Resultsmentioning

confidence: 99%

Detection of trace element levels in biological samples of drug abuser: Halani Sindh, Pakistan

Chang,

Balouch,

Nahyoon

et al. 2023

Preprint

View full text Add to dashboard Cite

Illicit drug use has become a global issue, posing significant health, socioeconomic, and cultural risks. The study examined essential trace metal selenium, zinc and copper in blood concentrations, serum and scalp hair samples, from male 240 drug-abuse subjects/patients aged 18–45 categorized into three age groups. The study compared 45 healthy subjects of the same age group using an acid-digestion method supported during sample preparation a microwave oven. The technique atomic-absorption spectrophotometry was employed to identify essential and toxic elements, utilizing certified reference materials for accuracy. Drug abusers' Se and Zn concentrations are lower than those of referent subjects, potentially increasing vulnerability to infection due to poor nutritional status or other contaminants.

show abstract

“…93 Using techniques like exposomics, it has been elucidated that BPA in combination with dietary dysbiosis can lead to fatty liver. 94 ics and high-content screening). 96 Nguyen et al evaluated the sex-and age-related effects of prenatal BPA exposure on altered transcriptome and proteome profiles of hepatic lipid homeostasis in rat offspring using the multiomics approach.…”

Section: B Is Phenol a And Liver D Is E A S E Smentioning

confidence: 99%

“…Metabolomics studies have highlighted impaired lipid metabolism in in vivo hepatic model 93 . Using techniques like exposomics, it has been elucidated that BPA in combination with dietary dysbiosis can lead to fatty liver 94 . In Steffensen et al.…”

Section: Bisphenol a And Liver Diseasesmentioning

confidence: 99%

Plastic compounds and liver diseases: Whether bisphenol A is the only culprit

Sangwan,

Bhattacharyya,

Banerjee

2024

Liver International

View full text Add to dashboard Cite

Plastics, while providing modern conveniences, have become an inescapable source of global concern due to their role in environmental pollution. Particularly, the focus on bisphenol A (BPA) reveals its biohazardous nature and association with liver issues, specifically steatosis. However, research indicates that BPA is just one facet of the problem, as other bisphenol analogues, microplastics, nanoplastics and additional plastic derivatives also pose potential risks. Notably, BPA is implicated in every stage of non‐alcoholic fatty liver disease (NAFLD) onset and progression, surpassing hepatitis B virus as a primary cause of chronic liver disease worldwide. As plastic contamination tops the environmental contaminants list, urgent action is needed to assess causative factors and mitigate their impact. This review delves into the molecular disruptions linking plastic pollutant exposure to liver diseases, emphasizing the broader connection between plastics and the rising prevalence of NAFLD.

show abstract

The exposome and liver disease - how environmental factors affect liver health

Cited by 35 publications

References 134 publications

Leveraging integrative toxicogenomic approach towards development of stressor-centric adverse outcome pathway networks for plastic additives

Leveraging integrative toxicogenomic approach towards development of stressor-centric adverse outcome pathway networks for plastic additives

Detection of trace element levels in biological samples of drug abuser: Halani Sindh, Pakistan

Plastic compounds and liver diseases: Whether bisphenol A is the only culprit

Contact Info

Product

Resources

About