The Experimental Animal Models in Psoriasis Research: A Comprehensive Review

Parab, Siddhi; Doshi, Gaurav Mahesh

doi:10.1016/j.intimp.2023.109897

Cited by 3 publications

(3 citation statements)

References 179 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…125 The results obtained from animal models play a crucial role in closing the gap between preclinical research and clinical trials. The challenges and limitations of animal models are presently being discussed, 9,126 with particular attention given to their validation for a specific purpose. Moreover, there are established guidelines that assist in choosing, developing, and implementing animal models for research purposes.…”

Section: Discussionmentioning

confidence: 99%

RNA-Based Antipsoriatic Gene Therapy: An Updated Review Focusing on Evidence from Animal Models

Lin,

Hung,

Aljuffali

et al. 2024

DDDT

View full text Add to dashboard Cite

Psoriasis presents as a complex genetic skin disorder, characterized by the interaction between infiltrated immune cells and keratinocytes. Substantial progress has been made in understanding the molecular mechanisms of both coding and non-coding genes, which has positively impacted clinical treatment approaches. Despite extensive research into the genetic aspects of psoriasis pathogenesis, fully grasping its epigenetic component remains a challenging endeavor. In response to the pressing demand for innovative treatments to alleviate inflammatory skin disorders, various novel strategies are under consideration. These include gene therapy employing antisense nucleotides, silencing RNA complexes, stem cell therapy, and antibody-based therapy. There is a pressing requirement for a psoriasis-like animal model that replicates human psoriasis to facilitate early preclinical evaluations of these novel treatments. The authors conduct a comprehensive review of various gene therapy in different psoriasis-like animal models utilized in psoriasis research. The animals included in the list underwent skin treatments such as imiquimod application, as well as genetic and biologic injections, and the results of these interventions are detailed. Animal models play a crucial role in translating drug discoveries from the laboratory to clinical practice, and these models aid in improving the reproducibility and clinical applicability of preclinical data. Numerous animal models with characteristics similar to those of human psoriasis have proven to be useful in understanding the development of psoriasis. In this review, the article focuses on RNA-based gene therapy exploration in different types of psoriasis-like animal models to improve the treatment of psoriasis.

show abstract

Section: Discussionmentioning

confidence: 99%

RNA-Based Antipsoriatic Gene Therapy: An Updated Review Focusing on Evidence from Animal Models

Lin,

Hung,

Aljuffali

et al. 2024

DDDT

View full text Add to dashboard Cite

show abstract

“…It is important to recognize, however, that no single animal model can fully replicate the complexity of a human disease. The scarcity of OLP animal models is in stark contrast to conditions like psoriasis, for which 47 different animal models are available to study specific pathogenetic aspects ( 22 ). This highlights a gap in the research and underscores the need for continued development of diverse and sophisticated models to better understand and treat complex diseases like OLP.…”

Section: Discussionmentioning

confidence: 99%

Animal models to study the pathogenesis and novel therapeutics of oral lichen planus

Choi

2024

Front. Oral. Health

View full text Add to dashboard Cite

Oral lichen planus (OLP) is a prevalent oral mucosal disease characterized by an unknown etiology and a complex pathogenesis. Patients with OLP endure a chronic course marked by alternating non-erosive and erosive lesions, with no definitive cure currently available. Particularly challenging is the treatment of recalcitrant erosive OLP, highlighting an urgent need for therapies targeting specific pathogenic pathways. In diseases like OLP, where the etiopathogenesis is intricate and elusive, animal models are indispensable for hypothesis testing and elucidating disease mechanisms. To date, only three animal models for oral lichenoid lesions have been reported in the literature. This Perspective paper evaluates these existing models, along with a novel OLP mouse model introduced at the 3rd International Conference on Oral Mucosal Immunity and Microbiome. The validity of these models is critically assessed, and their potential future applications in advancing our understanding of OLP are discussed.

show abstract

“…With the advent of genetic engineering technologies, several Ps-mouse models have been designed to overexpress or eliminate gene(s) of interest [ 75 ]. There are known to be a few global gene knock-in or knockout mouse models developing a Ps-like phenotype ( Supplementary Material Table S1 ) or other genetic designs that modulate mutant alleles [ 76 , 77 ]. Supplementary Material Table S1 presents the main engineered mouse models of Ps [ 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 ].…”

Section: Animal Experimental Models—direct Proof Of the Link Between ...mentioning

confidence: 99%

Insights into Nutritional Strategies in Psoriasis

et al. 2023

View full text Add to dashboard Cite

Psoriasis, an autoimmune chronic inflammatory skin condition, has a high incidence in the general population, reaching 2–4%. Its pathogenesis involves an interplay of genetic factors, immune disturbances, and environmental factors. Within the environmental factors that aid the appearance of this autoimmune skin disease, the Western lifestyle and overall diet play important roles in the steady growth in psoriasis prevalence. Furthermore, psoriasis is associated with comorbidities such as psoriatic arthritis, cardiovascular disease, metabolic syndrome, and obesity. Accumulating evidence suggests that obesity is an important risk factor for psoriasis. Moreover, obesity aggravates established psoriasis, and a reduction in the body mass index can improve the clinical outcomes of psoriasis and increase the efficacy of standard psoriasis therapies. The possible connection between this autoimmune disease and obesity relies on the fact that white adipose tissue is an essential endocrine organ that secretes an array of immune mediators and inflammatory and metabolic factors with pro-inflammatory action. Thus, immune-mediated mechanisms in both psoriasis and obesity conditions are common factors. This paper describes the factors that link obesity with skin autoimmune disease and highlights the importance of the stimulatory or regulatory effects of nutrients and food in psoriasis and the possible improvement of psoriasis through nutritional strategies.

show abstract

The Experimental Animal Models in Psoriasis Research: A Comprehensive Review

Cited by 3 publications

References 179 publications

RNA-Based Antipsoriatic Gene Therapy: An Updated Review Focusing on Evidence from Animal Models

RNA-Based Antipsoriatic Gene Therapy: An Updated Review Focusing on Evidence from Animal Models

Animal models to study the pathogenesis and novel therapeutics of oral lichen planus

Insights into Nutritional Strategies in Psoriasis

Contact Info

Product

Resources

About