During the COVID‐19 pandemic, support workers and health professionals caring for and supporting people with intellectual disabilities (ID) required new knowledge on, for example, treatment and infection prevention. ID care organizations had to quickly share up‐to‐date knowledge and encourage its application. This study explored the contextual factors influencing knowledge sharing and application in the care and support for people with ID, contrasted their relevance prior to and during the pandemic, and compared the relevance of these factors according to support workers and health professionals. In 2021, 160 Dutch professionals working with people with ID completed an online survey, with 69 being support workers and 91 being health professionals. For most of the participants, the contextual factors known to be relevant for knowledge sharing and application prior to the pandemic (e.g., the leadership of professionals, user‐friendliness of interventions) also helped them to process knowledge during the pandemic. These factors were rated equally or as being even more important (e.g., “Practice leadership of management” and “Office arrangements and Information and Communication Technology (ICT) systems”). Moreover, support workers and health professionals rated factors such as the available capacity of employees and office arrangements and ICT systems differently. The findings provide initial evidence that during a health crisis like the COVID‐19 pandemic, both the role and importance of contextual factors influencing knowledge sharing and application in the care and support for people with ID partially differ from prior to the pandemic.