The experiences and perceptions of female breast cancer patients regarding weight management during and after treatment for oestrogen-receptor positive disease: a qualitative study

JM, Saxton; Pickering, Katie; Wane, Sarah; Crank, Helen; AS, Anderson; Cain, Henry; Cohen, Jacob Willem; RJ, Copeland; Gray, Joanne; Hargreaves, Jackie; RJQ, McNally; Wilson, Christine Brown

doi:10.1186/s12885-022-10238-7

Cited by 4 publications

(1 citation statement)

References 49 publications

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“…Although the Guidelines for the Diagnosis and Treatment of Primary Liver Cancer [6] have been increasingly used to develop diagnostic and treatment strategies, these are often associated with dismal prognostic outcome because of elusive molecular mechanisms. [7,8] It is crucial to comprehensively investigate the molecular mechanisms related to liver cancer occurrence and development to detect and diagnose HCC early, provide timely and effective treatment, inhibit recurrence and metastasis, and improve patient prognosis, which can help explore novel therapeutic methods for HCC. SMPD4, a hydrolytic enzyme that hydrolyzes sphingomyelin to ceramides and phosphocholine, has been implicated in sphingomyelin metabolism.…”

Section: Introductionmentioning

confidence: 99%

High expression of SMPD4 promotes liver cancer and is associated with poor prognosis

Rongyue,

Yanze,

Zhiheng

et al. 2024

Preprint

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Background and objective: The expression of sphingomyelin phosphodiesterase 4 (SMPD4), a neutral sphingomyelin enzyme, is intricately associated with tumorigenesis and progression. However, its function in hepatocellular carcinoma (HCC) and its pathogenic mechanism remain largely unclear. We investigated the correlation between SMPD4 in HCC and its prognostic significance and functions in HCC cell proliferation, invasion, and migration. Methods The expression of SMPD4 was detected in different tumor types, such as HCC, using the database from The Cancer Genome Atlas (TCGA). The diagnostic significance of SMPD4 was evaluated using the area under the receiver operating characteristic (ROC) curve (AUC). The Kaplan–Meier curve analysis was conducted to assess the ability of SMPD4 to predict HCC prognosis. The relationship between SMPD4 expression and the degree of immune cell infiltration in HCC was examined using the Tumor Immune Estimation Resource (TIMER) database. In addition, we performed quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) to verify SMPD4 expression in 20 frozen liver cancer tissue samples and paired non-carcinoma liver tissues. Small interfering RNA (siRNA) was performed to silence SMPD4 in cancer cells. The effect of SMPD4 expression in liver cancer cells was measured through qRT-PCR and western blotting. The function of SMPD4 in the proliferation, invasion, and migration of Hep3B and HepG2 cells was validated using the CCK-8, EdU, wound healing, and Transwell assays. Finally, the relationship between SMPD4 and drug sensitivity was examined. Results Elevated expression of SMPD4 was recorded in 22 cancer types, including HCC. SMPD4 expression was related to gender, T stage, N stage, clinical stage, and pathological grade. The area under the ROC curve was 0.952, indicating the excellent diagnostic value of SMPD4. The Kaplan–Meier analysis demonstrated that SMPD4 upregulation was related to poor overall survival (OS) in patients with HCC. The functional enrichment analysis revealed the critical effect of SMPD4 on the cell cycle. Moreover, SMPD4 expression exhibited a positive relationship between the infiltration levels of B cells, CD8 T+ cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells. Knocking down SMPD4 significantly inhibited HCC cell growth, invasion, and migration. Finally, SMPD4 expression was related to drug sensitivity. Conclusions SMPD4 is upregulated in HCC, indicating poor prognosis. It could be used as a diagnostic and prognostic biomarker for HCC. Knocking down SMPD4 affects the ability of proliferation, migration, and invasion by regulating the expression of cell cycle genes.

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Section: Introductionmentioning

confidence: 99%

High expression of SMPD4 promotes liver cancer and is associated with poor prognosis

Rongyue,

Yanze,

Zhiheng

et al. 2024

Preprint

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Gewichtszunahme nach Brustkrebsdiagnose – ein noch unterschätztes Phänomen?

Colatruglio,

Theobald

2023

Deutsche Zeitschrift für Onkologie

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Zusammenfassung Ziel Die Gewichtszunahme bei Brustkrebspatientinnen ist ein bekannter Nebeneffekt von Chemo- und endokriner Therapie, welche das Risiko für die Gesamt- und brustkrebsspezifische Mortalität von Brustkrebspatientinnen (BKP) erhöht, die psychosoziale Gesundheit gefährdet und deshalb möglichst vermieden/ behandelt werden sollte. Hierzu können Ernährungsinterventionen einen wirksamen Beitrag leisten. Diese Arbeit untersucht, wie sensibilisiert Onkologinnen und Onkologen (ONKO) für das Phänomen sind, wie sie bei Gewichtszunahme von BKP vorgehen und welche Rolle die Zusammenarbeit mit Ernährungsfachpersonen dabei spielt. Methode Sieben auf gynäkologische Krebserkrankungen spezialisierte ONKO wurden anhand eines halbstrukturierten Interviewleitfadens interviewt. Die Datenanalyse erfolgte anhand einer qualitativ strukturierenden Inhaltsanalyse. Ergebnisse Vier Hauptkategorien konnten identifiziert werden, welche die unterschiedlichen Sicht- und Handlungsweisen der ONKO bezüglich der Gewichtszunahme bei BKP nach Diagnosestellung strukturieren: 1. Das Phänomen: Beobachtung und Folgen einer Gewichtszunahme; 2. Patientinnenbezogene Perspektivenübernahme bezüglich der Gewichtszunahme; 3. Maßnahmen gegen eine Gewichtszunahme bei BKP; 4. Maßnahmenleitende/-hemmende Gedanken bei einer Gewichtszunahme. Diskussion Die Handlungsweisen der ONKO (ungenügende Maßnahmen zur Prävention und Behandlung einer Gewichtszunahme bei BKP, seltene interprofessionelle Zusammenarbeit mit Ernährungsfachpersonen) lassen sich durch ihre Sichtweisen erklären: ONKO unterschätzen tendenziell: 1) die gesundheitliche Relevanz der Gewichtszunahme, 2) die für BKP subjektive Relevanz der Gewichtszunahme, 3) die fachliche Kompetenz von Ernährungsfachpersonen sowie 4) die Wirksamkeit von Ernährungsinterventionen. Schlussfolgerung Zur Förderung der Intention von ONKO, Maßnahmen gegen eine Gewichtszunahme zu treffen, sollten ihre Risikowahrnehmung (bezüglich gesundheitlicher Folgen einer Gewichtszunahme) sowie ihre Handlungsergebniserwartung (bezüglich Zusammenarbeit mit Ernährungsfachpersonen) erhöht werden.

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Meaningful consumer involvement in cancer care: a systematic review on co-design methods and processes

Kiss,

Jongebloed,

Baguley

et al. 2024

JNCI Cancer Spectrum

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Objective Although the benefits of consumer involvement in research and healthcare initiatives are known, there is a need to optimise this for all people with cancer. This systematic review aimed to synthesise and evaluate the application of co-design in the oncology literature and develop recommendations to guide the application of optimal co-design processes and reporting in oncology research, practice, and policy. Methods A systematic review of co-design studies in adults with cancer was conducted, searching MEDLINE, CINAHL, Embase and PsycINFO databases and included studies focused on two concepts, co-design and oncology. Results A total of 5652 titles and abstracts were screened, resulting in 66 eligible publications reporting on 51 unique studies. Four frameworks were applied to describe the co-design initiatives. Most co-design initiatives were designed for use in an outpatient setting (n = 38; 74%) and were predominantly digital resources (n = 14; 27%) or apps (n = 12; 23%). Most studies (n = 25; 49%) used a co-production approach to consumer engagement. Although some studies presented strong co-design methodology, most (n = 36; 70%) did not report the co-design approach and 14% used no framework. Reporting was poor for participant level of involvement, the frequency and time commitment of co-design sessions. Consumer participation level was predominantly collaborate (n = 25; 49%). Conclusions There are opportunities to improve the application of co-design in oncology research. This review has generated recommendations to guide i) methodology and frameworks, ii) recruitment and engagement of co-design participants, and iii) evaluation of the co-design process. These recommendations can help drive appropriate, meaningful, and equitable co-design, leading to better cancer research and care.

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The experiences and perceptions of female breast cancer patients regarding weight management during and after treatment for oestrogen-receptor positive disease: a qualitative study

Cited by 4 publications

References 49 publications

High expression of SMPD4 promotes liver cancer and is associated with poor prognosis

High expression of SMPD4 promotes liver cancer and is associated with poor prognosis

Gewichtszunahme nach Brustkrebsdiagnose – ein noch unterschätztes Phänomen?

Meaningful consumer involvement in cancer care: a systematic review on co-design methods and processes

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