The expansion of CD4+CD28- T cells in patients with rheumatoid arthritis

Abstract

(Print ISSN 1478-6354; Online ISSN 1478-6362). This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. AbstractClonal expansion of CD4 + CD28 -T cells is a characteristic finding in patients with rheumatoid arthritis (RA). Expanded CD4 + clonotypes are present in the peripheral blood, infiltrate into the joints, and persist for years. CD4 + CD28 -T cells are oligoclonal lymphocytes that are rare in healthy individuals but are found in high percentages in patients with chronic inflammatory diseases. The size of the peripheral blood CD4 + CD28 -T-cell compartment was determined in 42 patients with RA and 24 healthy subjects by two-color FACS analysis. The frequency of CD4 + CD28 -T cells was significantly higher in RA patients than in healthy subjects. Additionally, the number of these cells was significantly higher in patients with extra-articular manifestations and advanced joint destruction than in patients with limited joint manifestations. The results suggest that the frequency of CD4 + CD28 -T cells may be a marker correlating with extra-articular manifestations and joint involvement.Keywords: arthritis, CD4 + CD28 -, lymphocytes Open AccessAvailable online http://arthritis-research.com/content/5/4/R210 R211In the present study we evaluated the correlation between the CD4 + CD28 -T-cell subset and extra-articular manifestations, magnitude of joint involvement, and presence of rheumatoid factor. Material and methods PatientsForty-two patients (26 women, 16 men, age 24-74 years, mean 51.7 years) with rheumatoid arthritis diagnosed according to the criteria of the American College of Rheumatology were included in the study. The disease duration was 4-19 years (mean 12.8 years). Patients were recruited from the outpatient and inpatient population of the Department of Rheumatology, University Hospital, Szczecin, Poland. All subjects were white and were from the Pomeranian region of Poland.

How does cytomegalovirus factor into diseases of aging and vaccine responses, and by what mechanisms?

“…Specific immunopathogenic mechanisms through which CMV could contribute to aggravation of joint damage in RA patients include the expansion of CMV-specific CD4+ CD28− (Pawlik et al 2003) and CD8+CD28− (Rothe et al 2016) T cells, which directly contribute to tissue lesions.…”

Role of Lymphocytes in Myocardial Injury, Healing, and Remodeling After Myocardial Infarction

“…78 This uncommon T-cell subset is expanded in the elderly and especially in individuals with autoimmune disease, like rheumatoid arthritis. 79 In the context of cardiovascular disease, the CD4 + CD28…”

Association of the A Allele of the TNF-Alpha-308 G/A Gene Polymorphism with Radiographic Progression in Rheumatoid Arthritis

“…On the one hand, certain authors point to the existence of the association of -308 G/A polymorphism with a higher degree of joint destruction in patients with RA (7). On the other hand, the results obtained by other authors do not show any effect of -308 G/A polymorphism on the activity of the disease, a more severe course or prognosis of RA (8).…”