The expanding role of imaging in the management of renal cell carcinoma

Murphy, Gillian; Jhaveri, Kartik

doi:10.1586/era.11.122

Cited by 8 publications

(1 citation statement)

References 47 publications

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“…Management of RCC is benefiting from the increasing role of small tumour masses detection, greater understanding of the metabolic pathways involved, new targeted medical treatments for metastatic RCC, and evolving surgical and minimally invasive image-guided treatment techniques [8]. Although in the absence of biomarkers, renal imaging is most often recommended by advocates of screening, a confident histological classification and diagnosis with this technique is not always feasible, especially for some ambiguous cystic and solid renal lesions [9].…”

Section: Introductionmentioning

confidence: 99%

Urinary Signatures of Renal Cell Carcinoma Investigated by Peptidomic Approaches

et al. 2014

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Renal Cell Carcinoma (RCC) is typically asymptomatic and surgery usually increases patient's lifespan only for early stage tumours. Moreover, solid renal masses cannot be confidently differentiated from RCC. Therefore, markers to distinguish malignant kidney tumours and for their detection are needed. Two different peptide signatures were obtained by a MALDI-TOF profiling approach based on urine pre-purification by C8 magnetic beads. One cluster of 12 signals could differentiate malignant tumours (n = 137) from benign renal masses and controls (n = 153) with sensitivity of 76% and specificity of 87% in the validation set. A second cluster of 12 signals distinguished clear cell RCC (n = 118) from controls (n = 137) with sensitivity and specificity values of 84% and 91%, respectively. Most of the peptide signals used in the two models were observed at higher abundance in patient urines and could be identified as fragments of proteins involved in tumour pathogenesis and progression. Among them: the Meprin 1α with a pro-angiogenic activity, the Probable G-protein coupled receptor 162, belonging to the GPCRs family and known to be associated with several key functions in cancer, the Osteopontin that strongly correlates to tumour stages and invasiveness, the Phosphorylase b kinase regulatory subunit alpha and the SeCreted and TransMembrane protein 1.

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Section: Introductionmentioning

confidence: 99%