Introduction. In this paper we obtain a simple theorem on the existence of periodic solutions of differential systems possessing certain symmetry properties. These symmetry properties are closely related to those considered recently by Kotin [1] and his results can also be obtained from this theorem. The theorem is very general and describes periodic solutions for both autonomous and nonautonomous systems. Our main purpose here is to illustrate applications by considering specific examples from a variety of applied problems. An important special case deals with the nonlinear oscillator (1)which has been investigated previously in [2]. Periodic solutions of this two dimensional system are easily constructed by employing elementary geometrical and analytical arguments together with the general existence theorem. Since the discussion in [2] is quite extensive, we shall not reconsider this special case. Indeed, our examples here mainly concern higher dimensional systems.2. General existence theorem. Consider the differential equationwhere , ] are n-dimensional (column) vectors and is a scalar time variable. Let ](t, ) be periodic in with period P (or be independent of t) and assume that there exists a unique solution of (2) through any point of some prescribed region of the (t, ) -space and that the variables always remain in this region. In the following discussions we will use some notations and concepts introduced by Hale [3].The system (2) is said to possess property E with respect to Q if Q is an n X n (constant) matrix satisfying (3) ](--t, Q) -Q](t, ), for all and z. In [3], the additional requirements that Q be nonsingular and satisfy Q I and PoQ QPo, where P0 is a certain averaging operator, *