The Excretion of Vitamin C in Normal Individuals Following a Comparable Quantitative Administration in the form of Orange Juice, Cevitamic Acid by Mouth and Cevitamic Acid Intravenously

Hawley, Estelle E.; Stephens, D. J.; Anderson, George K.

doi:10.1093/jn/11.2.135

Cited by 36 publications

(6 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In agreement with our current human study, others have shown little difference in steady-state plasma and/or urine bioavailability of synthetic vitamin C and that found in different fruits, fruit juices and vegetables [14,15,16,17,18,19]. Only one previous study has investigated the comparative bioavailability of synthetic versus natural vitamin C in leukocytes [19].…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

A Randomized Steady-State Bioavailability Study of Synthetic versus Natural (Kiwifruit-Derived) Vitamin C

et al. 2013

View full text Add to dashboard Cite

Whether vitamin C from wholefoods has equivalent bioavailability to a purified supplement remains unclear. We have previously showed that kiwifruit provided significantly higher serum and tissue ascorbate levels than synthetic vitamin C in a genetically vitamin C-deficient mouse model, suggesting a synergistic activity of the whole fruit. To determine if these results are translatable to humans, we carried out a randomized human study comparing the bioavailability of vitamin C from kiwifruit with that of a vitamin C tablet of equivalent dosage. Thirty-six young non-smoking adult males were randomized to receive either half a gold kiwifruit (Actinidia Chinensis var. Hort 16A) per day or a comparable vitamin C dose (50 mg) in a chewable tablet for six weeks. Ascorbate was monitored weekly in fasting venous blood and in urine, semen, leukocytes, and skeletal muscle (vastus lateralis) pre- and post-intervention. Dietary intake of vitamin C was monitored using seven day food and beverage records. Participant ascorbate levels increased in plasma (P < 0.001), urine (P < 0.05), mononuclear cells (P < 0.01), neutrophils (P < 0.01) and muscle tissue (P < 0.001) post intervention. There were no significant differences in vitamin C bioavailability between the two intervention groups in any of the fluid, cell or tissue samples tested. Overall, our study showed comparable bioavailability of synthetic and kiwifruit-derived vitamin C.

show abstract

Section: Discussionsupporting

confidence: 91%

“…Several previous studies have tested the comparative bioavailability of synthetic versus food-derived vitamin C utilizing plasma and/or urine levels [14,15,16,17,18]. However, only one has investigated the comparative bioavailability of vitamin C in leukocytes [19].…”

Section: Introductionmentioning

confidence: 99%

A Randomized Steady-State Bioavailability Study of Synthetic versus Natural (Kiwifruit-Derived) Vitamin C

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Hospital, New York City) (Received for publication July 28, 1938) The work of numerous investigators has shown that vitamin C is excreted in the urine (1,2,3,4,5,6,7), and various suggestions have been made as to the relation between the rate of excretion and the concentration in the blood. None of the reported observations, however, are of such a quantitative nature as to afford a description of the mechanism of its excretion.…”

mentioning

confidence: 99%

The Mechanism of the Excretion of Vitamin C by the Human Kidney 1

Ralli¹,

Friedman²,

Rubin³

1938

J. Clin. Invest.

View full text Add to dashboard Cite

“…Communications by Harris et al (1,2), Johnson and Zilva (3), van Eekelen (4), Hawley et al (5), and Youmans et al (6) have established the relationship of the output of vitamin C in the urine to the nutritional state of the organism with respect to this vitamin. They have shown that subjects maintained on diets inadequate in their vitamin C content, excrete only traces of ascorbic acid in the urine.…”

mentioning

confidence: 99%