The excretion of sulfur compounds in the urine of newborn infants

Finnström, Orvar; Lundqvist, Per; Mårtensson, Jerker; Sörbo, Bo

doi:10.1016/0026-0495(83)90133-6

Cited by 12 publications

(3 citation statements)

References 26 publications

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“…Finnstrom et al [16] found that the relative S 0 4 excretion rates in normal newborns and in fasting adults were 196 ±34 (n = 8) and 126± 10 (n = 6) pm ol/kg/day, respectively, bracketing our results of 141-147 pm ol/kg/day. The excretion rate found by Michalk et al [7] in 38 children aged 2-8 years with various kidney disorders is also comparable: 9.5 ±(SD)2.9 mmol/1.73 mVday or 136±41 um ol/kg/day.…”

Section: Discussionsupporting

confidence: 73%

Clearance of Inorganic Sulfate by Peritoneal Dialysis in Children with Chronic Renal Failure

et al. 1986

Nephron

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The peritoneal clearance of inorganic sulfate was measured in 6 infants and 12 children with end-stage renal disease who were receiving continuous ambulatory peritoneal dialysis. Serum sulfate, which was elevated before dialysis, changed little during the 5-hour dialysis period. The dialysis sulfate concentration increased at the same rate as creatinine. Net clearance of the two metabolites was not different. It was calculated that the removal by continuous ambulatory peritoneal dialysis in 24 h is comparable to the daily excretion of SO₄ in healthy children.

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Section: Discussionsupporting

confidence: 73%

Clearance of Inorganic Sulfate by Peritoneal Dialysis in Children with Chronic Renal Failure

et al. 1986

Nephron

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“…Serum sulfate concentrations are elevated in human infants, in children under 3 years of age, and pregnant women (14)(15)(16). The urinary excretion of inorganic sulfate in human infants is very low compared with adults (17), suggesting the increased conservation of inorganic sulfate in the young. Renal tubular reabsorption of inorganic sulfate is greater in young (<25 days) than adult (>60 days) guinea pigs (18).…”

mentioning

confidence: 99%

Effect of Pregnancy, Postnatal Growth, and Gender on Renal Sulfate Transport

Lee¹,

Balasubramanian²,

Morris³

1999

Experimental Biology and Medicine

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Serum sulfate concentrations are increased in infants, young children, and pregnant women, compared with adult values. The objective of this investigation was to examine the influences of age, gender, and pregnancy on renal sulfate transport using guinea pigs as an animal model. Membrane vesicles were isolated from the kidney cortex of male animals at four different ages, from male and female adult animals, and from pregnant and nonpregnant female animals. There were no significant differences in marker enzymes for the brush-border membrane (BBM) or basolateral membrane (BLM) among all groups examined. Uptake was determined by a rapid filtration method and membrane fluidity by measuring the steady-state fluorescence anisotropy of 1,6-diphenyl-1,3,5-hexatriene. The V max values for Na + /sulfate cotransport in BBM were significantly increased with decreasing age, whereas the K m for this process was unchanged. The V max and K m for Na + /sulfate co-transport in BBM of pregnant animals were significantly higher than the values in the nonpregnant group. Bicarbonate-driven anion exchange of sulfate in BLM was not different among the different age groups. The V max for the bicarbonate/sulfate exchange process in BLM was not different between pregnant and nonpregnant groups; however, the K m for this process in BLM of pregnant animals was significantly greater than the value in nonpregnant animals. There were no gender-related differences in sulfate transport in BBM or BLM isolated from adult male and female animals. Renal BBM fluidity was increased with decreasing age and in pregnant animals, suggesting that altered membrane fluidity may represent one possible mechanism to explain the increased sodium/sulfate uptake in young and pregnant animals. The higher V max for Na + /sulfate co-transport in young and pregnant animals suggests that there is an increased density of co-transporter protein or an increase in the rate of movement of the carrier protein (i.e., turnover) once loaded with sodium and sulfate. This increased conservation of inorganic sulfate in young and pregnant guinea pigs may be related to the increased demand for sulfated substrates, such as sulfated glycosaminoglycans, during growth and development.

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“…Tubular phosphate reabsorption improves with increasing gesta tional and postnatal ages [1,5,15]. Similar maturational patterns for the renal handling of lactate, urate and other organic anions have been reported [10,24], Furthermore, significant amounts of inorganic sulfate, which is freely filtered and actively reab sorbed by the proximal tubule, have been found in the urine of low birth weight pre mature infants [7,13]. As to the unmeasured ionic composition of neonatal urine, it should also be noted that in addition to the process of maturation, the infants' condi tion, dietary intake and acid-base balance may induce substantial but not always predictable variations [6,9,13,22,27].…”

Section: Resultsmentioning

confidence: 51%

Relationship of Urinary Anion Gap to Urinary Ammonium Excretion in the Neonate

Sulyok

Guignard²

1990

Neonatology

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The present study was undertaken to define the relationship of urinary anion gap (UAG = sodium plus potassium minus chloride) to urine ammonium concentration in preterm and full-term neonates with spontaneous and NH₄Cl-induced metabolic acidosis. Studies were performed in 10 premature infants (mean birth weight: 1,618 g, gestational age: 30.8 weeks) weekly for 6 consecutive weeks, in 11 full-term neonates (mean birth weight: 3,085 g, gestational age: 38.6 weeks) on the 7th day of life and in 25 older control infants (mean age: 6.5 months, body weight: 6,802 g) before and after NH₄Cl-loading test.

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The excretion of sulfur compounds in the urine of newborn infants

Cited by 12 publications

References 26 publications

Clearance of Inorganic Sulfate by Peritoneal Dialysis in Children with Chronic Renal Failure

Clearance of Inorganic Sulfate by Peritoneal Dialysis in Children with Chronic Renal Failure

Effect of Pregnancy, Postnatal Growth, and Gender on Renal Sulfate Transport

Relationship of Urinary Anion Gap to Urinary Ammonium Excretion in the Neonate

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