The Evolving View of IL-17-Mediated Immunity in Defense Against Mucocutaneous Candidiasis in Humans

Soltész, Beáta; Töth, Beáta; Sarkadi, Adrien Katalin; Erdős, Melinda; Maródi, László

doi:10.3109/08830185.2015.1049345

Cited by 16 publications

(13 citation statements)

References 104 publications

(169 reference statements)

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“…HIES is manifested as a T H 2 phenotype concomitant with the absence of T H 17 cells [ 26 ] but it is not clear whether this clinical presentation is because of the lack of RORγt, IL-17A, IL-17A receptor (IL-17RA), or STAT3. It is known that IL-17RA deficiency leads to susceptibility to mucocutaneous Candidiasis but not to S. aureus [ 27 ]. In addition, a more recent publication noted that RORγt deficiency in itself results in susceptibility to Candida and Mycobacterium infections but not to increased susceptibility to S. aureus [ 28 ].…”

Section: Innate and Adaptive Immune Responses To S Aurementioning

confidence: 99%

“…If so, the former response would conduce to protection upon re-exposure, whereas the later would not. However, this may not be applicable to the same extent in humans because patients with a defect in RORγt or IL-17 receptor signaling, which lead to impaired T H 17 responses, show no increased susceptibility to repeated S. aureus infections [ 27 , 28 ].…”

Section: Innate and Adaptive Immune Responses To S Aurementioning

confidence: 99%

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Immunomodulation and Disease Tolerance to Staphylococcus aureus

Peres

Damian

et al. 2015

Pathogens

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The Gram-positive bacterium Staphylococcus aureus is one of the most frequent pathogens that causes severe morbidity and mortality throughout the world. S. aureus can infect skin and soft tissues or become invasive leading to diseases such as pneumonia, endocarditis, sepsis or toxic shock syndrome. In contrast, S. aureus is also a common commensal microbe and is often part of the human nasal microbiome without causing any apparent disease. In this review, we explore the immunomodulation and disease tolerance mechanisms that promote commensalism to S. aureus.

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Section: Innate and Adaptive Immune Responses To S Aurementioning

confidence: 99%

Section: Innate and Adaptive Immune Responses To S Aurementioning

confidence: 99%

Immunomodulation and Disease Tolerance to Staphylococcus aureus

Peres

Damian

et al. 2015

Pathogens

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“…These β-defensins have potent fungicidal activity enabling the epithelium to prevent invasion of C. albicans . IL-17A and IL-17F induce neutrophil recruitment from the bloodstream to the site of infection where these cells aid to prevent Candida dissemination [ 6 , 7 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 ].…”

Section: Mucocutaneous Candidiasismentioning

confidence: 99%

Patient Susceptibility to Candidiasis—A Potential for Adjunctive Immunotherapy

Davidson

Netea

Kullberg

2018

JoF

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Candida spp. are colonizing fungi of human skin and mucosae of the gastrointestinal and genitourinary tract, present in 30-50% of healthy individuals in a population at any given moment. The host defense mechanisms prevent this commensal fungus from invading and causing disease. Loss of skin or mucosal barrier function, microbiome imbalances, or defects of immune defense mechanisms can lead to an increased susceptibility to severe mucocutaneous or invasive candidiasis. A comprehensive understanding of the immune defense against Candida is essential for developing adjunctive immunotherapy. The important role of underlying genetic susceptibility to Candida infections has become apparent over the years. In most patients, the cause of increased susceptibility to fungal infections is complex, based on a combination of immune regulation gene polymorphisms together with other non-genetic predisposing factors. Identification of patients with an underlying genetic predisposition could help determine which patients could benefit from prophylactic antifungal treatment or adjunctive immunotherapy. This review will provide an overview of patient susceptibility to mucocutaneous and invasive candidiasis and the potential for adjunctive immunotherapy.

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“…In order to determine whether our observations in vitro are relevant for immune responses in vivo, we examined skin biopsy tissue from patients with C. albicans skin infections, a prototypical example of dermatological disease in which a Th17 response is protective (45). We stained skin lesions with antibodies against CD3, PDPN, and IL-17.…”

Section: Podoplanin Is Expressed On Non-il-17-secreting T Cells In Camentioning

confidence: 99%