The evolving role of α-glucosidase inhibitors

Göke, Burkhard; Herrmann-Rinke, C.

doi:10.1002/(sici)1099-0895(199809)14:1+<s31::aid-dmr226>3.3.co;2-v

Cited by 44 publications

(18 citation statements)

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“…17) NHF is consisted of Polygonati Rhizoma, Rehmanniae Radix Crudus, Salviae miltiorrhizae Radix, Puerariae Radix, Schizandrae Fructus, and Glycyrrhizae Radix. In traditional Oriental medicine, Polygonati Rhizoma, 18) Rehmanniae Radix Crudus, 19) Puerariae Radix 20) and Schizandrae Fructus 21) have been used mainly for the decrease of blood glucose.…”

Section: Fig 6 Histological Observations and Immunohistochemical Stmentioning

confidence: 99%

Anti-diabetic Effects of New Herbal Formula in Neonatally Streptozotocin-Induced Diabetic Rats

Kim

Lee

Kwon

et al. 2009

Biological & Pharmaceutical Bulletin

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The present study investigated the anti-diabetic effects of new herbal formula (NHF) consist of Polygonati Rhizoma, Rehmanniae Radix, Salviae miltiorrhizae Radix, Puerariae Radix, Schizandrae Fructus, Glycyrrhizae Radix in neonatal streptozotocin (nSTZ)-induced non-insulin-dependent diabetes mellitus (NIDDM) rats. Changes of food and water intakes, body weight, blood glucose, plasma insulin and immunohistochemical evaluation of insulin on pancreas, and mRNA expression of glucose transporter subtype-4 (GLUT-4) in skeletal muscle and hepatic phosphoenolpyruvate carboxykinase (PEPCK) by administration of NHF (300 mg/kg) were investigated. The nSTZ diabetic rats showed hyperglycemia, increases in food and water intake, loss of body weight gain and decrease of the number of insulin-positive cells and the size of b b-cells in pancreas and mRNA of GLUT-4 in soleus muscle and increase of hepatic PEPCK mRNA expression. Administration of NHF significantly decreased the blood glucose level, food and water intake and considerably increased the body weight of nSTZ diabetic rats. Also, NHF treatment significantly increased plasma insulin level and the number and size of insulinimmunoreactive cells in the pancreas of nSTZ diabetic rats. In addition, NHF treatment resulted in increased expression of the GLUT-4 mRNA in soleus muscle and in reduced expression of PEPCK mRNA in liver. These results provide possible mechanisms for the anti-diabetic effects of NHF, via a decrease of blood glucose level, an increase of insulin sensitivity, an increase of GLUT-4 gene expression and an attenuation of hepatic PEPCK gene expression. In conclusion, NHF may be useful for improving hyperglycemia and reducing the risk of diabetic complications.

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Section: Fig 6 Histological Observations and Immunohistochemical Stmentioning

confidence: 99%

Anti-diabetic Effects of New Herbal Formula in Neonatally Streptozotocin-Induced Diabetic Rats

Kim

Lee

Kwon

et al. 2009

Biological & Pharmaceutical Bulletin

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“…One therapeutic approach for treating type 2 diabetes mellitus is to decrease the post-prandial glucose levels. This could be done by retarding the absorption of glucose through the inhibition of the carbohydrates-hydrolysing enzymes, -glucosidase and -amylase, present in the small intestinal brush border that are responsible for the breakdown of oligosaccharides and disaccharides into monosaccharides suitable for absorption (1,7,9,10). Inhibitors of these enzymes, like acarbose, delay carbohydrate digestion and prolong overall carbohydrate digestion time, causing a reduction in the rate of glucose absorption and consequently blunting the postprandial plasma glucose rise (1,4).…”

Section: Introductionmentioning

confidence: 99%

α-Amylase Inhibitors: A Review of Raw Material and Isolated Compounds from Plant Source

et al. 2012

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-Inhibition of α-amylase, enzyme that plays a role in digestion of starch and glycogen, is considered a strategy for the treatment of disorders in carbohydrate uptake, such as diabetes and obesity, as well as, dental caries and periodontal diseases. Plants are an important source of chemical constituents with potential for inhibition of α-amylase and can be used as therapeutic or functional food sources. A review about crude extracts and isolated compounds from plant source that have been tested for α-amylase inhibitory activity has been done. The analysis of the results shows a variety of crude extracts that present α-amylase inhibitory activity and some of them had relevant activity when compared with controls used in the studies. Amongst the phyto-constituents that have been investigated, flavonoids are one of them that demonstrated the highest inhibitory activities with the potential of inhibition related to number of hydroxyl groups in the molecule of the compound. Several phyto-constituents and plant species as α-amylase inhibitors are being reported in this article. Majority of studies have focused on the anti-amylase phenolic compounds.

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“…For example, ␣-glucosidase inhibitors, such as acarbose, voglibose, and miglitol, are prescribed in clinical practice to control postprandial blood glucose. Those inhibitors inhibit the digestion of carbohydrates, delay the absorption of carbohydrates from the gastrointestinal tract, and consequently suppress the postprandial elevation of the blood glucose level (Göke and Herrmann-Rinke, 1998). It has also been reported that acarbose is effective in preventing or delaying the incidence of diabetes when applied to patients with impaired glucose tolerance (Chiasson et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

KGA-2727, a Novel Selective Inhibitor of a High-Affinity Sodium Glucose Cotransporter (SGLT1), Exhibits Antidiabetic Efficacy in Rodent Models

Shibazaki

Tomae²,

Ishikawa-Takemura³

et al. 2012

J Pharmacol Exp Ther

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The evolving role of α-glucosidase inhibitors

Cited by 44 publications

References 0 publications

Anti-diabetic Effects of New Herbal Formula in Neonatally Streptozotocin-Induced Diabetic Rats

Anti-diabetic Effects of New Herbal Formula in Neonatally Streptozotocin-Induced Diabetic Rats

α-Amylase Inhibitors: A Review of Raw Material and Isolated Compounds from Plant Source

KGA-2727, a Novel Selective Inhibitor of a High-Affinity Sodium Glucose Cotransporter (SGLT1), Exhibits Antidiabetic Efficacy in Rodent Models

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