2005
DOI: 10.1101/sqb.2005.70.033
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The Evolving Portrait of Cancer Metastasis

Abstract: The phenomenon of cancer metastasis remains poorly understood. We discuss here various conceptual frameworks that attempt to rationalize the mechanisms by which tumors acquire metastatic ability. Portrayal of cancer as a somatic Darwinian process occurring within a tissue fails to fully explain the phenomenon of metastatic competence. The biology of pre-neoplastic cells also complicates this picture, since the phenotypes of normal cellular precursors are clearly relevant to metastatic behavior following transf… Show more

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Cited by 80 publications
(51 citation statements)
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“…These changes in Sca-1 + colony size are probably attributed to the increase in proliferation that was observed in the miR-205-overexpressing cells. (Mattie et al, 2006); f BC compared with normal breast (Volinia et al, 2006); within a genomically amplified region in BC (Blenkiron et al, 2007) (Mattie et al, 2006); F BC compared with normal breast (Volinia et al, 2006); within a genomically amplified region in BC (Blenkiron et al, 2007) (Mattie et al, 2006); F BC compared with normal breast (Volinia et al, 2006); within a genomically amplified region in BC (Blenkiron et al, 2007) (Mattie et al, 2006); located near the HOXC cluster, a potential site for disregulation in cancer (Calin et al, 2004); within a genomically amplified region in BC (Blenkiron et al, 2007) miR-34a -2.82 F PR + BC (Mattie et al, 2006); within a deleted region associated with BC (Calin et al, 2004;Gupta et al, 2005) Rajewsky and Socci, 2004), but often these algorithms will predict different targets for the same miRNA. PTEN was identified as a predicted target of miR-205 by the miRanda algorithm at the miRNA Viewer website (http://cbio.mskcc.org/mirnaviewer/).…”
Section: Resultsmentioning
confidence: 99%
“…These changes in Sca-1 + colony size are probably attributed to the increase in proliferation that was observed in the miR-205-overexpressing cells. (Mattie et al, 2006); f BC compared with normal breast (Volinia et al, 2006); within a genomically amplified region in BC (Blenkiron et al, 2007) (Mattie et al, 2006); F BC compared with normal breast (Volinia et al, 2006); within a genomically amplified region in BC (Blenkiron et al, 2007) (Mattie et al, 2006); F BC compared with normal breast (Volinia et al, 2006); within a genomically amplified region in BC (Blenkiron et al, 2007) (Mattie et al, 2006); located near the HOXC cluster, a potential site for disregulation in cancer (Calin et al, 2004); within a genomically amplified region in BC (Blenkiron et al, 2007) miR-34a -2.82 F PR + BC (Mattie et al, 2006); within a deleted region associated with BC (Calin et al, 2004;Gupta et al, 2005) Rajewsky and Socci, 2004), but often these algorithms will predict different targets for the same miRNA. PTEN was identified as a predicted target of miR-205 by the miRanda algorithm at the miRNA Viewer website (http://cbio.mskcc.org/mirnaviewer/).…”
Section: Resultsmentioning
confidence: 99%
“…The actual implementation by these cells of their EMT program depends on a series of intracellular signaling networks involving, among other signaltransducing proteins, ERK, MAPK, PI3K, Akt, Smads, RhoB, β-catenin, lymphoid enhancer binding factor (LEF), Ras, and c-Fos as well as cell surface proteins such as β4 integrins, Îą5β1 integrin, and ÎąVβ6 integrin (80). Activation of EMT programs is also facilitated by the disruption of cell-cell adherens junctions and the cell-ECM adhesions mediated by integrins (67,75,(81)(82)(83)(84)(85)(86).…”
Section: Type 3 Emt: Emt Associated With Cancer Progression and Metasmentioning
confidence: 99%
“…carcinoma | receptor tyrosine kinase | breast cancer M etastasis to distant sites is the most common cause of death from carcinomas (1). Malignant cells discard epithelial restraints and acquire invasive motility that facilitates dissemination to permissive niches (2).…”
mentioning
confidence: 99%