The evolving landscape of salivary gland tumors

Steuer, Conor; Hanna, Glenn J.; Viswanathan, Kartik; Bates, James E.; Kaka, Azeem; Schmitt, Nicole C.; Ho, Alan L.; Saba, Nabil F.

doi:10.3322/caac.21807

Cited by 12 publications

(7 citation statements)

References 205 publications

(361 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The SMIF is a safe and reliable flap with minimal donor site morbidity, simple harvest, and excellent contour and color match for lateral head and neck defects. 8 Multiple locoregional flaps have been described for reconstruction of lateral facial defects including myofascial flaps, such as the temporalis or sternocleidomastoid, and axial flaps, including the supraclavicular island, lower trapezius island, and pectoralis major myocutaneous flaps. However, muscle flaps may create unsightly cosmetic deformities and have a tendency to atrophy significantly over time.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, we describe our modifications to the SMIF and the use of this in the reconstruction of lateral facial, parotid, and temporal bone defects. The SMIF is a safe and reliable flap with minimal donor site morbidity, simple harvest, and excellent contour and color match for lateral head and neck defects 8 . Multiple locoregional flaps have been described for reconstruction of lateral facial defects including myofascial flaps, such as the temporalis or sternocleidomastoid, and axial flaps, including the supraclavicular island, lower trapezius island, and pectoralis major myocutaneous flaps.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Submental Island Flaps for Lateral Reconstruction: Technical Refinements for Optimal Outcomes and Resource Efficiency

Oh,

Vettikattu,

Baddour

et al. 2024

OTO Open

Self Cite

View full text Add to dashboard Cite

ObjectiveTo describe our modifications to the submental island flap (SMIF) in a case series that demonstrates improved reproducibility, shortened length of stay (LOS), and reduced utilization of hospital resources.Study DesignThis retrospective case series with chart review included adult patients who underwent resection of malignant or benign tumors resulting in lateral facial, parotid, or temporal bone defects, which were reconstructed with SMIF.SettingA tertiary‐care academic referral center.MethodsRetrospective case series included all adult patients who underwent SMIF reconstruction between March 2020 and August 2021. Patient demographic and clinical data were collected. Primary outcomes were measures of hospital utilization including duration of surgery, LOS, and postoperative outcomes.ResultsTwenty‐eight patients were included with a mean age of 71.7 years. Eighty percent were male. All patients underwent parotidectomy, and the mean operative time was 347 minutes. The median LOS was 2.5 days (range 0‐16 days). Seventy‐five percent of the flaps drained into the internal jugular vein, and 25% drained into the external jugular vein. No patients required reoperation or readmission. All flaps survived.ConclusionSMIFs are a safe and effective option for reconstruction of lateral facial, parotid, and temporal bone defects. Compared to free flap reconstruction, SMIFs offer reduced length of surgery, decreased use of health care resources, and lower rate of reoperation. As health care resource allocation is increasingly important, the SMIF offers an excellent alternative to free flap reconstruction of lateral defects.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Submental Island Flaps for Lateral Reconstruction: Technical Refinements for Optimal Outcomes and Resource Efficiency

Oh,

Vettikattu,

Baddour

et al. 2024

OTO Open

Self Cite

View full text Add to dashboard Cite

show abstract

“…Currently, surgical resection remains the primary treatment modality for PTs; However, different histological subtypes necessitate distinct surgical approaches and prognostic evaluations. Malignant parotid tumors (MPT) require more aggressive surgical techniques such as total parotidectomy [ 3 , 4 ]. The fine needle aspiration cytology (FNAC) is the most commonly used qualitative method for preoperative diagnosis of PTs [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Deep learning-assisted diagnosis of benign and malignant parotid tumors based on ultrasound: a retrospective study

Jiang,

Chen,

Zhou

et al. 2024

BMC Cancer

View full text Add to dashboard Cite

Background To develop a deep learning(DL) model utilizing ultrasound images, and evaluate its efficacy in distinguishing between benign and malignant parotid tumors (PTs), as well as its practicality in assisting clinicians with accurate diagnosis. Methods A total of 2211 ultrasound images of 980 pathologically confirmed PTs (Training set: n = 721; Validation set: n = 82; Internal-test set: n = 89; External-test set: n = 88) from 907 patients were retrospectively included in this study. The optimal model was selected and the diagnostic performance evaluation is conducted by utilizing the area under curve (AUC) of the receiver-operating characteristic(ROC) based on five different DL networks constructed at varying depths. Furthermore, a comparison of different seniority radiologists was made in the presence of the optimal auxiliary diagnosis model. Additionally, the diagnostic confusion matrix of the optimal model was calculated, and an analysis and summary of misjudged cases’ characteristics were conducted. Results The Resnet18 demonstrated superior diagnostic performance, with an AUC value of 0.947, accuracy of 88.5%, sensitivity of 78.2%, and specificity of 92.7% in internal-test set, and with an AUC value of 0.925, accuracy of 89.8%, sensitivity of 83.3%, and specificity of 90.6% in external-test set. The PTs were subjectively assessed twice by six radiologists, both with and without the assisted of the model. With the assisted of the model, both junior and senior radiologists demonstrated enhanced diagnostic performance. In the internal-test set, there was an increase in AUC values by 0.062 and 0.082 for junior radiologists respectively, while senior radiologists experienced an improvement of 0.066 and 0.106 in their respective AUC values. Conclusions The DL model based on ultrasound images demonstrates exceptional capability in distinguishing between benign and malignant PTs, thereby assisting radiologists of varying expertise levels to achieve heightened diagnostic performance, and serve as a noninvasive imaging adjunct diagnostic method for clinical purposes.

show abstract

“…These changes are not based on the result of phase 3 trials of major carcinomas; they are based on phase 2 trials based on genetic alterations. In this era, analyses of genetic alterations are more important for histological diagnoses and the development of novel targeted therapies for SGCs 20 …”

Section: Introductionmentioning

confidence: 99%

Comprehensive genomic profiling of salivary gland carcinoma: Analysis of the Center for Cancer Genomics and Advanced Therapeutics database in Japan

Iwaki,

Kawakita,

Nagao

et al. 2024

Intl Journal of Cancer

View full text Add to dashboard Cite

Comprehensive information on genetic alterations in salivary gland cancer (SGC) is limited. This study aimed to elucidate the genetic and clinical characteristics of patients with SGC using the Center for Cancer Genomics and Advanced Therapeutics (C‐CAT) database, a Japanese national genomic database. We analyzed data of 776 patients with SGC registered in the C‐CAT database between June 1, 2019, and June 30, 2023. Adenoid cystic carcinoma was the most common histologic type, followed by salivary duct carcinoma (SDC) and adenocarcinoma not otherwise specified. Genetic data of 681 patients receiving FoundationOne® CDx were analyzed. We identified specific features of the combination of TP53 and CDKN2A alterations among the histological types. Specific LYN amplification was mainly detected in carcinoma ex pleomorphic adenoma and myoepithelial carcinoma. For SDC, the frequency of ERBB2 and BRAF alterations were higher in cases with metastatic lesions than in those with primary lesions. Although 28.6% patients were offered recommended treatment options, only 6.8% received the recommended treatments. This study highlights the differences in genetic alterations among the histological types of SGC, with comprehensive genomic profiling tests revealing lower drug accessibility. These findings could contribute to the development of personalized treatment for patients with SGC.

show abstract

The evolving landscape of salivary gland tumors

Cited by 12 publications

References 205 publications

Submental Island Flaps for Lateral Reconstruction: Technical Refinements for Optimal Outcomes and Resource Efficiency

Submental Island Flaps for Lateral Reconstruction: Technical Refinements for Optimal Outcomes and Resource Efficiency

Deep learning-assisted diagnosis of benign and malignant parotid tumors based on ultrasound: a retrospective study

Comprehensive genomic profiling of salivary gland carcinoma: Analysis of the Center for Cancer Genomics and Advanced Therapeutics database in Japan

Contact Info

Product

Resources

About