The evolving HIV epidemic and its impact on the HIV testing algorithm: Is it time to change the HIV testing algorithm in South Africa?

Mashishi, Bonolo; Makatini, Zinhle; Adu-Gyamfi, Clement

doi:10.1016/j.jcv.2021.104990

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…Rapid initiation of ART is a guidelines-supported intervention to shorten time to viral suppression and improve clinical outcomes [ 18–21 ]. The HIV screening algorithm plays a large role in ensuring that rapid ART initiation can occur [ 11 , 12 , 22 ]. Achieving rapid ART initiation can be facilitated by drawing a plasma sample that can be used for all steps of the diagnostic algorithm, thus avoiding delays caused by additional blood draws [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Reflex Human Immunodeficiency Virus (HIV) Type 1 RNA Testing Enables Timely Differentiation of False-Positive Results From Acute HIV Infection

Kaperak,

Eller,

Devlin

et al. 2023

Open Forum Infectious Diseases

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Section: Discussionmentioning

confidence: 99%

Reflex Human Immunodeficiency Virus (HIV) Type 1 RNA Testing Enables Timely Differentiation of False-Positive Results From Acute HIV Infection

Kaperak,

Eller,

Devlin

et al. 2023

Open Forum Infectious Diseases

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“…This technology was implemented based on evidence that the lack of confidentiality is one of the major contributing factors that limited testing uptake in workers [8,9]. Thus, it was recommended for South Africa to change the HIV testing algorithm [10] by targeting the working class and offering them HIV self-testing kits. Some suggested that HIVST may increase the demand for testing in the working populations [11].…”

Section: Introductionmentioning

confidence: 99%

The Impact and Spillover Effects of HIV Self-Test Technology on HIV Outcomes of the South African Working Class

Mostert

2022

Venereology

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Background: South Africa recently adopted HIV self-test technology (HIVST) to improve HIV testing and encourage earlier treatment initiation in working populations with a low uptake of conventional testing approaches. This study investigates the impact of HIVST on testing outcomes, focusing on both frequent and infrequent working-class testers. The paper also examines the spillover effect of HIVST on antiretroviral (ART) treatment initiation. To identify these effects, the author focused on South Africa and exploited the HIVST distribution data of 6259 beneficiaries of HIVST. Methods: The author used a two-stage least-squared model to quantify the impact of the HIVST on these vulnerable working populations. Results: The results show that HIVST fosters a 27.6% higher testing uptake in infrequently testing workers compared to frequently testing workers, and that the uptake of HIVST is 11.5% higher in rural regions than in urban settings, as well as 14.5% more prominent in infrequent male testers than infrequent female testers. Notably, the positive effects of HIVST are also confirmed by the presence of positive spillover effects in workers screening positive for HIV. The paper documents a 7.6% increase in ART initiation in infrequent testers. Conclusions: There is a case for adopting this technology to improve the uptake of HIV testing and ART initiation as the country seeks to attain the UNAIDS 95–95–95 targets by 2030.

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The evolving HIV epidemic and its impact on the HIV testing algorithm: Is it time to change the HIV testing algorithm in South Africa?

Cited by 2 publications

References 25 publications

Reflex Human Immunodeficiency Virus (HIV) Type 1 RNA Testing Enables Timely Differentiation of False-Positive Results From Acute HIV Infection

Reflex Human Immunodeficiency Virus (HIV) Type 1 RNA Testing Enables Timely Differentiation of False-Positive Results From Acute HIV Infection

The Impact and Spillover Effects of HIV Self-Test Technology on HIV Outcomes of the South African Working Class

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