The evolutionary origins of the lysosome-related organelle sorting machinery reveal fundamental homology in post-endosome trafficking pathways
Kiran J. More,
Joel B. Dacks,
Paul T. Manna
Abstract:The major organelles and pathways of the endomembrane system were in place by the time of the last eukaryotic common ancestor (LECA) (~1.5 billion years ago) and their acquisition were defining milestones during the process of eukaryogenesis itself. Comparative cell biology and evolutionary analyses show multiple instances of homology in the protein machinery controlling distinct inter-organelle trafficking routes. Resolving these homologous relationships allows us to explore processes underlying the emergence… Show more
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