The evolutionary dynamics of alternative splicing during primate neuronal differentiation
Alex Ritter,
Andrew Wallace,
Neda Ronaghi
et al.
Abstract:Alternative splicing (AS) is emerging as an important regulatory process for complex biological processes such as neuronal differentiation. To uncover the functional consequences of AS during neuronal differentiation we performed a comparative transcriptomic analysis using human, rhesus, chimpanzee and orangutan pluripotent stem cells. Transcriptomic studies commonly involve the identification and quantification of alternative processing events, but the need for predicting the functional consequences of change… Show more
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