The Evolution of Soft Tissue Fillers in Clinical Practice

Murray, Christian; Zloty, David; Warshawski, Laurence M.

doi:10.1016/j.det.2004.09.009

Cited by 106 publications

(110 citation statements)

References 31 publications

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“…HA is in vivo mainly degraded through hydrolysis catalyzed by hyaluronidases giving safe products. It has been estimated that the half-life of HA in the skin is about 24h, in the eye 24-36h, in the cartilage 1-3 weeks and 70 days in the vitreous humor (Laurent & Reed, 1991;Stern et al, 2007;Murray et al, 2005). Because of the above highlighted properties, the development and commercialization of HA based products are in continuous intensification (Widner et al, 2005).…”

Section: Hyaluronan Applicationsmentioning

confidence: 99%

Biotechnological Production and Application of Hyaluronan

Schiraldi¹,

Gatta²,

Rosa³

2010

Biopolymers

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Section: Hyaluronan Applicationsmentioning

confidence: 99%

Biotechnological Production and Application of Hyaluronan

Schiraldi¹,

Gatta²,

Rosa³

2010

Biopolymers

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“…4,5 The first of these, medical grade fluid silicone of 350 centistokes (cS), was manufactured by Dow Corning, Inc., from 1954 to 1992, but banned by the U.S.…”

Section: Dermal Fillersmentioning

confidence: 99%

Avoiding and Treating Dermal Filler Complications

Lemperle

Rullan

Gauthier-Hazan

2006

Plastic and Reconstructive Surgery

234

226

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Summary: All fillers are associated with the risk of both early and late complications. Early side effects such as swelling, redness, and bruising occur after intradermal or subdermal injections. The patient has to be aware of and accept these risks. Adverse events that last longer than 2 weeks can be attributable to technical shortcomings (e.g., too superficial an implantation of a long-lasting filler substance). Such adverse events can be treated with intradermal 5-fluorouracil, steroid injections, vascular lasers, or intense pulsed light, and later with dermabrasion or shaving. Late adverse events also include immunologic phenomena such as late-onset allergy and nonallergic foreign body granuloma. Both react well to intralesional steroid injections, which often have to be repeated to establish the right dose. Surgical excisions shall remain the last option and are indicated for hard lumps in the lips and visible hard nodules or hard granuloma in the subcutaneous fat. (Plast. Reconstr. Surg. 118 (Suppl.): 92S, 2006.) The aesthetic benefit the patient achieves with temporary fillers is 90 percent technique and 10 percent substance. With permanent fillers, it's 99 percent technique.Jean Carruthers 1 A ll injectable dermal fillers can cause complications. Late side effects can be divided into those caused by insufficient training or technical errors during injection and those caused by immunologic (allergic and nonallergic) reactions to the injected substance. In the case of late, nonallergic reactions, the pathologic substratum differs from injectable to injectable but can always be classified into one of three distinct forms of foreign body granuloma.2 The histologic reaction is always similar, 3 and the trigger for this sudden stimulation of macrophages might be a systemic infection of the patient.

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“…In selected individuals, soft tissue filler injections can provide an immediately visible result in the convenience of the office setting, and the procedure is minimally invasive and has a good safety record. Despite its temporary longevity, it is popular because it is simple, effective, and economical [2,3].…”

mentioning

confidence: 99%

Structured Nonsurgical Asian Rhinoplasty

Kim¹,

Ahn

2012

Aesth Plast Surg

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The Asian nose is characterized by a flat nasal bridge, indistinct dorsal aesthetic line, an underprojected and broad nasal tip, and a short columella. Cosmetic procedures to enhance these features are popular in Asians and surgical rhinoplasty is the therapeutic gold standard for individuals seeking to enhance the appearance of their nose. However, in recent years, there appears to be an increasing number of Asians seeking nonsurgical rhinoplasty and this tendency is seen in both primary and revision cases. The biggest strength of filler rhinoplasty is that it is minimally invasive, has a good safety record, provides immediately visible results, and can be done conveniently in the office setting without the downtime of surgery. Despite its temporary longevity, it is popular because it is simple, effective, and economical. This article describes a "structured" nonsurgical Asian rhinoplasty approach using dermal fillers that can produce a comprehensive cosmetic enhancement of the Asian nose.

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The Evolution of Soft Tissue Fillers in Clinical Practice

Cited by 106 publications

References 31 publications

Biotechnological Production and Application of Hyaluronan

Biotechnological Production and Application of Hyaluronan

Avoiding and Treating Dermal Filler Complications

Structured Nonsurgical Asian Rhinoplasty

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