The evolution of multiplex detection of mycotoxins using immunoassay platform technologies

Adunphatcharaphon, Saowalak; Elliott, Christopher T.; Sooksimuang, Thanasat; Charlermroj, Ratthaphol; Petchkongkaew, Awanwee; Karoonuthaisiri, Nitsara

doi:10.1016/j.jhazmat.2022.128706

Cited by 50 publications

(19 citation statements)

References 98 publications

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“…Such methods offer effective monitoring of various mycotoxin contamination in food/feed on the spot. Recently, an increasing trend has been observed for the development of simultaneous detection of mycotoxins arising from the rapid immunoassay concept [ 30 ]. Enzyme-linked immunosorbent assay (ELISA) is a classic immunoassay that has been widely used [ 31 ].…”

Section: Development Of Mycotoxin Analytical Methodsmentioning

confidence: 99%

Recent advances in immunoassay-based mycotoxin analysis and toxicogenomic technologies

Liew¹,

Sabran²

2022

Journal of Food and Drug Analysis

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The co-occurrence and accumulation of mycotoxin in food and feed constitutes a major issue to food safety, food security, and public health. Accurate and sensitive mycotoxins analysis can avoid toxin contamination as well as reduce food wastage caused by false positive results. This mini review focuses on the recent advance in detection methods for multiple mycotoxins, which mainly depends on immunoassay technologies. Advance immunoassay technologies integrated in mycotoxin analysis enable simultaneous detection of multiple mycotoxins and enhance the outcomes’ quality. It highlights toxicogenomic as novel approach for hazard assessment by utilizing computational methods to map molecular events and biological processes. Indeed, toxicogenomic is a powerful tool to understand health effects from mycotoxin exposure as it offers insight on the mechanisms by which mycotoxins exposures cause diseases.

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Section: Development Of Mycotoxin Analytical Methodsmentioning

confidence: 99%

Recent advances in immunoassay-based mycotoxin analysis and toxicogenomic technologies

Liew¹,

Sabran²

2022

Journal of Food and Drug Analysis

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“…Due to the disadvantages of these assays, such as the high cost of instrumentation, the complex sample preparation, the time-consuming processes, and the susceptibility to matrix interference [ 47 , 48 ], emerging rapid immunoassays, including fluorescence polarization immunoassay, chemiluminescence immunoassay, surface plasmon resonance immunosensing, electrochemical immunosensing, surface-enhanced Raman scattering immunosensing, and colorimetric aptamer sensors, have been proposed [ 49 , 50 , 51 , 52 , 53 , 54 ]. Although these immunoassay technologies show excellent performance and efficiency in detecting mycotoxins, several issues, such as poor sensitivity and bio-selectivity, high quantitative requirements, and the observation that some methods do not achieve the purpose of point-of-need rapidly, are big hurdles to commercializing such sensing techniques [ 48 , 55 ].…”

Section: Ota Detection Methods For Dry-cured Hamsmentioning

confidence: 99%

Ochratoxin A in Dry-Cured Ham: OTA-Producing Fungi, Prevalence, Detection Methods, and Biocontrol Strategies—A Review

Chen

Jiang

Zhu

et al. 2022

Toxins

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Traditional dry-cured hams are easily contaminated by toxigenic fungi during the fermentation and ripening stages. The detection and positive rates of ochratoxin A (OTA) are the highest among mycotoxins detected in traditional dry-cured hams, indicating that OTA in hams is a potential safety hazard to human health. This review addresses the mycotoxin-producing fungal species, the toxigenic conditions causing OTA contamination worldwide, the prevalence of OTA contamination in dry-cured hams, and the detection methods applied in OTA analysis. Additionally, this study introduces methods to prevent and control OTA in traditional dry-cured hams. The growth of common mycotoxin-producing fungi and the accumulation of mycotoxins in dry-cured ham can be controlled by a microbial starter. This review provides an important theoretical foundation for the research and control of OTA in traditional dry-cured hams.

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“…To date, numerous reviews have reported the use of various sensing platforms for mycotoxin detection. For example, Adunphatcharaphon et al (2022) summarized the application of various single-mode immunosensors in the detection of mycotoxins in the past 5 years, Zhai et al (2021) reviewed the research progress of SERS-based biosensors and SERS combined with other technologies in the detection of mycotoxins, and focused on the application of biosensors in AFs. However, multi-mode sensing platforms have not been specifically reviewed as an emerging technology for mycotoxin detection.…”

Section: Introductionmentioning

confidence: 99%

Advances in immunoassay‐based strategies for mycotoxin detection in food: From single‐mode immunosensors to dual‐mode immunosensors

Chen

Qileng

Liang

et al. 2023

Comp Rev Food Sci Food Safe

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Mycotoxin contamination in foods and other goods has become a broad issue owing to serious toxicity, tremendous threat to public safety, and terrible loss of resources. Herein, it is necessary to develop simple, sensitive, inexpensive, and rapid platforms for the detection of mycotoxins. Currently, the limitation of instrumental and chemical methods cannot be massively applied in practice. Immunoassays are considered one of the best candidates for toxin detection due to their simplicity, rapidness, and cost‐effectiveness. Especially, the field of dual‐mode immunosensors and corresponding assays is rapidly developing as an advanced and intersected technology. So, this review summarized the types and detection principles of single‐mode immunosensors including optical and electrical immunosensors in recent years, then focused on developing dual‐mode immunosensors including integrated immunosensors and combined immunosensors to detect mycotoxins, as well as the combination of dual‐mode immunosensors with a portable device for point‐of‐care test. The remaining challenges were discussed with the aim of stimulating future development of dual‐mode immunosensors to accelerate the transformation of scientific laboratory technologies into easy‐to‐operate and rapid detection platforms.

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The evolution of multiplex detection of mycotoxins using immunoassay platform technologies

Cited by 50 publications

References 98 publications

Recent advances in immunoassay-based mycotoxin analysis and toxicogenomic technologies

Recent advances in immunoassay-based mycotoxin analysis and toxicogenomic technologies

Ochratoxin A in Dry-Cured Ham: OTA-Producing Fungi, Prevalence, Detection Methods, and Biocontrol Strategies—A Review

Advances in immunoassay‐based strategies for mycotoxin detection in food: From single‐mode immunosensors to dual‐mode immunosensors

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