The Evolution of Intracardiac Hemodynamics Post Autologous Stem Cell Transplant in a Case of Multiple Myeloma Associated with Severe Tricuspid and Mitral Valve Insufficiency

Abstract

Stem cells are undifferentiated cells that can divide and become differentiated. Hematopoietic stem cells cannot transform into new stem cells such as cardiomyocytes or new heart valves, but they act through paracrine effects, by secreting cytokines and growth factors that lead to an increase in contractility and overall improved function. In this case report, we present how autologous stem cell transplantation can bring two major benefits: the first refers to hematological malignancy and the second is about the improvement of the heart condition. We present the case of a 60-year-old patient diagnosed with multiple myeloma suffering from a bi-valve severe condition in which autologous stem cell transplantation led to the remission of the patient’s malignant disease and also improved the heart function.

Modern Hematology — a Complex Interdisciplinary Tool

“…More specifically, Tudor et al presented a patient with multiple myeloma, who went into the remission phase after stem cell transplantation, and presented an increase in the left ventricular ejection fraction from 50 to 60%, a smaller mitral regurgitation jet, and also a lower systolic pressure in the pulmonary artery. 19 The success of stem cell treatment on both the hematological condition as well as the associated cardiovascular condition is indicative of the pluripotent capacity of these novel treatments in complex patients with multiple comorbidities.…”