This chapter explores correlations between modern and ancient science as they apply to cognitive-sentient reality. The ancient wisdom and worldviews were based on a combination of reason and introspection—the frontier between certainty and uncertainty. This exploration was paramount in Egyptian, Greek, Chinese, Indian, and other cultures and philosophies. This contemplation is actually universal, and virtually all culture has contributed to the structuring of fundamental sentient patterns of cognitive reality. Taking into account some recent scientific discoveries at micro/macro levels, the concepts of certainty/uncertainty, and information science, the chapter argues the coincidence between the ancient model of chakras and a newer cognitive-informational model. Based on these correlations, a new model of cognitive-sentient exploration of reality (CSER) is discussed relative to its use as in analytical/synergistic model for research on cosmic sentience.