The evolution of clinical and laboratory features enteroviral meningitis in children

Kokoreva, S.P.; Kazartseva, Natalya V.; Котлова, В. Б.

doi:10.22627/2072-8107-2019-18-4-43-48

Det. infekc.

2019

DOI: 10.22627/2072-8107-2019-18-4-43-48

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The evolution of clinical and laboratory features enteroviral meningitis in children

S.P. Kokoreva¹,

Natalya V. Kazartseva²,

В. Б. Котлова³

Abstract: In recent years, enterovirus infection (EVI) retains its cyclical nature with an increase in the incidence rate in the Russian Federation in 2000, 2006, 2009, 2013 and 2017. Observation of 41 patients with laboratory-confirmed enteroviral meningitis (EVM) in 2000, 54 children in 2013, and 56 patients in 2018 revealed the clinical and laboratory features of this clinical form of the disease, mainly concerning changes in hemo- and liquorogram parameters, which allowed to trace the evolutionary changes during thi… Show more

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Enterovirus vesicular stomatitis with exanthema: Epidemiological Features and Vaccination

Sytaya

Mindlina

2022

Epidemiology and Vaccinal Prevention

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Relevance. Hand, foot and mouth disease (HFMD) is a disease that is extremely relevant for the Russian Federation. According to modern data, epidemic outbreaks of severe course involving a large number of children are registered in the Russian Federation. At the same time, the mortality rate varies worldwide and can range from 6.46 to 51.00 per 100 thousand population. In addition, the fact that the Russian Federation borders with East and Southeast Asia annually increases the risk of HFMD entering the territory of Russia. Every year, the disease causes more than 2 million hospitalizations in Asia. Aims. According to the literature, to analyze the epidemiological characteristics of HFMD in the Russian Federation and the world, as well as the prospects for vaccination of this infection. To achieve this goal, open sources hosted in the electronic databases PubMed, Medline and e-Library were used. Publications on enterovirus infection for the period from 2014 to 2022 are analyzed. The WHO (Western Pacific Region) statistics on HFMD were also used. Results. According to the modern literature, HFMD is the most common clinical form of enterovirus infection, which is characterized by high heterogeneity of pathogens. Over the past few years, the incidence of enterovirus infection in many subjects of the Russian Federation has been characterized by an upward trend. The most unfavorable epidemic situation in the Russian Federation is observed on the territory of the Far Eastern Federal District, where the largest number of cases of enterovirus infection is registered. In 2018, 1058 cases of enterovirus infection were detected in the Sakhalin region (222.6 cases per 100 thousand). The structure of enterovirus infection in the Russian Federation is dominated by exanthemic forms, herpangina and gastroenteritis. It is necessary to consider the introduction of vaccination of the child population, since rises in the incidence of enterovirus infection in various regions are registered annually on the territory of the Russian Federation. Vaccines against EV-A71 are already being used in China for epidemic indications. The active circulation of HFMD in the Asia-Pacific region may affect the spread of enterovirus infection in the territory of the Russian Federation, as the risk of imported cases of infection and the formation of epidemic foci of group morbidity increases.

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Enterovirus vesicular stomatitis with exanthema: Epidemiological Features and Vaccination

Sytaya

Mindlina

2022

Epidemiology and Vaccinal Prevention

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Changes in the urinary system in children with enterovirus infection

Kokoreva¹,

Kazartseva

2021

RPJ

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A significant increase in the incidence of enterovirus infections (EVI) with the development of multiple organ damage does not exclude the involvement of the urinary system organs in the pathological process. Materials and methods. 151 EVI children (103 cases with enterovirus meningitis (EVM), 48 children with other forms of EVI without damage of central nervous system) aged from 1 to 18 years. The frequency and nature of changes in urinary sediment and kidney function in patients with various EVI forms were studied. A highly sensitive marker of acute kidney injury - KIM-1 was used as a marker along with standard methods (determination of blood creatinine level with calculation of glomerular filtration rate) in 25 EVM patients. Results. Pathological changes in urinary sediment in EVI are registered in 37.75% of cases (27.1-42.72%, depending on the clinical form), more often in preschool children, are represented by unexpressed proteinuria and abacterial leukocyturia, and are of a short-term transient nature. 40% of EVM children patients showed an increase in the KIM-1 level above the standard values. Conclusion. The detection of KIM-1 in the urine of EVM children patients indicates the possible development of acute transient tubulointerstitial renal damage. At risk there are children with cerebrospinal fluid pleocytosis greater than 200×106/L, abacterial leukocyturia, and decreased glomerular filtration rate.

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The evolution of clinical and laboratory features enteroviral meningitis in children

Cited by 2 publications

References 2 publications

Enterovirus vesicular stomatitis with exanthema: Epidemiological Features and Vaccination

Enterovirus vesicular stomatitis with exanthema: Epidemiological Features and Vaccination

Changes in the urinary system in children with enterovirus infection

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