The evolution of class I MHC genes

Klein, Jan; Figueroa, Felipe

doi:10.1016/0167-5699(86)90123-4

Cited by 81 publications

(44 citation statements)

References 25 publications

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“…In the three regions of the MHC, sequence comparisons between species show a high level of similarity between homologous genes Klein and Figueroa, 1986).…”

Section: Ggacgcccactcggggggcatcgtgcccaacggcgacggcacctaccacacctgggtcacmentioning

confidence: 99%

A molecular map of the chicken major histocompatibility complex: the class II beta genes are closely linked to the class I genes and the nucleolar organizer.

et al. 1988

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“…In the three regions of the MHC, sequence comparisons between species show a high level of similarity between homologous genes Klein and Figueroa, 1986).…”

Section: Ggacgcccactcggggggcatcgtgcccaacggcgacggcacctaccacacctgggtcacmentioning

confidence: 99%

A molecular map of the chicken major histocompatibility complex: the class II beta genes are closely linked to the class I genes and the nucleolar organizer.

et al. 1988

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“…The approximately 12S band in bmll RNA (Fig. Sc) (12,14,15,35). In contrast, the Qa and Tla class I MHC genes display little sequence diversity among the few alleles detected (8,14).…”

mentioning

confidence: 99%

“…The K and D regions contain the genes encoding the classical H-2 transplantation antigens (K, D, L) which are found on all somatic cells and which function as restricting elements in the presentation of foreign, cell-associated antigens to T cells. Alleles of each H-2 locus exhibit approximately 10 to 15% nucleotide sequence diversity (diversity refers to differences in primary sequence) and are very polymorphic at the population level (12,14,15,35). The diversity and polymorphism of H-2 gene products are thought to be important in their function as antigen-presenting molecules.…”

mentioning

confidence: 99%

Microrecombinations generate sequence diversity in the murine major histocompatibility complex: analysis of the Kbm3, Kbm4, Kbm10, and Kbm11 mutants.

Geliebter

Nathenson

1988

Mol. Cell. Biol.

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The mechanism that generates spontaneous mutants of the Kb histocompatibility gene was analyzed. Nucleotide sequence analysis of four mutant genes (Kbm3, Kbm4, Kbm10, and Kbm11) revealed that each mutant K gene contains clustered, multiple nucleotide substitutions. Hybridization analyses of parental B6 genomic DNA and cloned class I genes with mutant-specific oligonucleotide probes, followed by sequence analyses, have identified major histocompatibility complex class I genes in the K, D, and Tla regions (K1, Db, and T5, respectively) that contain the exact sequences as substituted into mutant Kb genes. These data provide evidence for the hypothesis that the mutant Kb genes are generated by a microrecombination (gene conversion) mechanism that results in the transfer of small DNA segments from class I genes of all four regions of the major histocompatibility complex (K, D, Qa, and Tla) to Kb. Many of the nucleotides substituted into the mutant Kb genes were identical to those found in other naturally occurring K alleles such as Kd. Thus, we propose that the accumulation of microrecombination products within the K genes of a mouse population is responsible for the high sequence diversity among H-2 alleles.

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“…Conserved amino acid residues, resembling those in many of the mouse or rabbit class I proteins (22), can be found in the RS5-encoded protein where it diverges from the human class I proteins. Such amino acid residues are seen at position 10 sequence divergence between the three external domains of RS5 and HLA-A, -B, and -C locus proteins is of the same order as noticed between H2 and several of the Qa/TL region gene products (6).…”

Section: Discussionmentioning

confidence: 99%

Structure, expression, and molecular mapping of a divergent member of the class I HLA gene family.

Srivastava

Chorney

Lawrance

et al. 1987

Proc. Natl. Acad. Sci. U.S.A.

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A class I gene distinct from HLA-A, -B, or -C was identified in a cosmid clone and transfected into mouse L cells. The gene, placed adjacent to the polyoma enhancer, produced a full-length class I mRNA and high levels of a 43-kDa protein in the cytoplasm. The surface expression of the gene product required its association with human beta 2-microglobulin. The protein was recognized by a xenoantiserum raised against a mixture of human B- and T-cell lines. The product was also serologically reactive with the HLA framework monoclonal antibodies. The complete nucleotide sequence of the gene was determined and a specific oligonucleotide probe was synthesized. This probe was used to identify a full-length mRNA transcript in a B-lymphoblastoid cell line (JY). The gene was mapped within a 190-kilobase Not I restriction fragment located in the telomeric portion of the human major histocompatibility complex. Distinct features of the gene include the structure of the promoter, the position of the translation initiation site, a frameshift mutation at the carboxyl terminus, the insertion of an Alu repeat element in the eighth exon, divergence in the derived amino acid sequence, and the lack of expression of the gene in some cells.

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The evolution of class I MHC genes

Cited by 81 publications

References 25 publications

A molecular map of the chicken major histocompatibility complex: the class II beta genes are closely linked to the class I genes and the nucleolar organizer.

A molecular map of the chicken major histocompatibility complex: the class II beta genes are closely linked to the class I genes and the nucleolar organizer.

Microrecombinations generate sequence diversity in the murine major histocompatibility complex: analysis of the Kbm3, Kbm4, Kbm10, and Kbm11 mutants.

Structure, expression, and molecular mapping of a divergent member of the class I HLA gene family.

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