The evolution of ADAM gene family in eukaryotes

Souza, Juliana Sacramento Mota de; Lisboa, A.B.P.; Santos, Túlio M.; Andrade, M.V.S.; Neves, V.B.S; Teles-Souza, Jéssica; Jesus, Hendor N. R.; Bezerra, Tony Gigliotti; Falcão, Valéria Gomes Oliveira; Oliveira, Rodrigo Cunha; Del-Bem, Luiz-Eduardo

doi:10.1016/j.ygeno.2020.05.010

Cited by 15 publications

(8 citation statements)

References 76 publications

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“…The other is the proteolytic cleavage of mbIL-6R, which is dependent on the activity of a disintegrin and metalloprotease (ADAM). The ADAM family metalloproteases are involved in the proteolysis of adhesion molecules, cytokines/chemokines, growth factors [ 73 ], and many cytokine receptors, such as TNFR, IL-1R, and IL-6R [ 74 , 75 ]. IL-6R is a substrate of ADAM10 and ADAM17 [ 76 ], which both belong to the transmembrane ADAMs family [ 77 ].…”

Section: Classical Signaling and Trans -Signaling Of Il-6mentioning

confidence: 99%

Anti-Inflammatory Effect of Muscle-Derived Interleukin-6 and Its Involvement in Lipid Metabolism

Nara

Watanabe

2021

IJMS

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Interleukin (IL)-6 has been studied since its discovery for its role in health and diseases. It is one of the most important pro-inflammatory cytokines. IL-6 was reported as an exacerbating factor in coronavirus disease. In recent years, it has become clear that the function of muscle-derived IL-6 is different from what has been reported so far. Exercise is accompanied by skeletal muscle contraction, during which, several bioactive substances, collectively named myokines, are secreted from the muscles. Many reports have shown that IL-6 is the most abundant myokine. Interestingly, it was indicated that IL-6 plays opposing roles as a myokine and as a pro-inflammatory cytokine. In this review, we discuss why IL-6 has different functions, the signaling mode of hyper-IL-6 via soluble IL-6 receptor (sIL-6R), and the involvement of soluble glycoprotein 130 in the suppressive effect of hyper-IL-6. Furthermore, the involvement of a disintegrin and metalloprotease family molecules in the secretion of sIL-6R is described. One of the functions of muscle-derived IL-6 is lipid metabolism in the liver. However, the differences between the functions of IL-6 as a pro-inflammatory cytokine and the functions of muscle-derived IL-6 are unclear. Although the involvement of myokines in lipid metabolism in adipocytes was previously discussed, little is known about the direct relationship between nonalcoholic fatty liver disease and muscle-derived IL-6. This review is the first to discuss the relationship between the function of IL-6 in diseases and the function of muscle-derived IL-6, focusing on IL-6 signaling and lipid metabolism in the liver.

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Section: Classical Signaling and Trans -Signaling Of Il-6mentioning

confidence: 99%

Anti-Inflammatory Effect of Muscle-Derived Interleukin-6 and Its Involvement in Lipid Metabolism

Nara

Watanabe

2021

IJMS

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“…A disintegrin and metalloproteinase (ADAM) and a disintegrin and metalloproteinases with thrombospondin motif (ADAM-TS) are normally multidomain proteins of more than 800 AA that typically comprise: (i) a signal peptide, (ii) a pro-domain, (iii) a catalytic domain with a reprolysin-type zinc-binding motif (HEXXHXXG/N/SXXHD), and (iv) a disintegrin-like domain. The disintegrin domain may be followed in some proteins by an ADAM-cysteine rich (ADAM-CR) domain and a C-terminus of varying length [ 40 , 41 , 42 ]. The different domains can be cleaved from the catalytic domain after secretion to give rise to the mature protein [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

Proteo-Trancriptomic Analyses Reveal a Large Expansion of Metalloprotease-Like Proteins in Atypical Venom Vesicles of the Wasp Meteorus pulchricornis (Braconidae)

Gatti

Belghazi

Legeai

et al. 2021

Toxins

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Meteorus pulchricornis (Ichneumonoidea, Braconidae) is an endoparasitoid wasp of lepidopteran caterpillars. Its parasitic success relies on vesicles (named M. pulchricornis Virus-Like Particles or MpVLPs) that are synthesized in the venom gland and injected into the parasitoid host along with the venom during oviposition. In order to define the content and understand the biogenesis of these atypical vesicles, we performed a transcriptome analysis of the venom gland and a proteomic analysis of the venom and purified MpVLPs. About half of the MpVLPs and soluble venom proteins identified were unknown and no similarity with any known viral sequence was found. However, MpVLPs contained a large number of proteins labelled as metalloproteinases while the most abundant protein family in the soluble venom was that of proteins containing the Domain of Unknown Function DUF-4803. The high number of these proteins identified suggests that a large expansion of these two protein families occurred in M. pulchricornis. Therefore, although the exact mechanism of MpVLPs formation remains to be elucidated, these vesicles appear to be “metalloproteinase bombs” that may have several physiological roles in the host including modifying the functions of its immune cells. The role of DUF4803 proteins, also present in the venom of other braconids, remains to be clarified.

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“…With regard to rest genes with no detected enriched GO terms, ADAM22 is a member of the ADAM (A Disintegrin And Metalloprotease) gene family that are involved in a broad range of biological processes such as cell fusion, spermatogenesis and development [ 65 ] and in the regulation of cell adhesion and inhibition of cell proliferation [ 66 ]. The gene has been associated with rumen microbial composition in sheep [ 67 ] and with reproductive traits in Nelore cattle [ 68 ].…”

Section: Discussionmentioning

confidence: 99%

Genetic differentiation of mainland-island sheep of Greece: Implications for identifying candidate genes for long-term local adaptation

et al. 2021

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In Greece, a number of local sheep breeds are raised in a wide range of ecological niches across the country. These breeds can be used for the identification of genetic variants that contribute to local adaptation. To this end, 50k genotypes of 90 local sheep from mainland Greece (Epirus, n = 35 and Peloponnesus, n = 55) were used, as well as 147 genotypes of sheep from insular Greece (Skyros, n = 21), Lemnos, n = 36 and Lesvos, n = 90). Principal components and phylogenetic analysis along with admixture and spatial point patterns analyses suggested genetic differentiation of ‘mainland-island’ populations. Genome scans for signatures of selection and genome-wide association analysis (GWAS) pointed to one highly differentiating marker on OAR4 (FST = 0.39, FLK = 21.93, FDR p-value = 0.10) that also displayed genome wide significance (FDR p-value = 0.002) during GWAS. A total number of 6 positional candidate genes (LOC106990429, ZNF804B, TEX47, STEAP4, SRI and ADAM22) were identified within 500 kb flanking regions around the significant marker. In addition, two QTLs related to fat tail deposition are reported in genomic regions 800 kb downstream the significant marker. Based on gene ontology analysis and literature evidence, the identified candidate genes possess biological functions relevant to local adaptation that worth further investigation.

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The evolution of ADAM gene family in eukaryotes

Cited by 15 publications

References 76 publications

Anti-Inflammatory Effect of Muscle-Derived Interleukin-6 and Its Involvement in Lipid Metabolism

Anti-Inflammatory Effect of Muscle-Derived Interleukin-6 and Its Involvement in Lipid Metabolism

Proteo-Trancriptomic Analyses Reveal a Large Expansion of Metalloprotease-Like Proteins in Atypical Venom Vesicles of the Wasp Meteorus pulchricornis (Braconidae)

Genetic differentiation of mainland-island sheep of Greece: Implications for identifying candidate genes for long-term local adaptation

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