Abstract:Introduction: the PICO mnemonic is an evidence-based medicine tool that helps formulate the research questions needed to conduct the right search for scientific information. To properly classify this information, controlled languages or thesauruses are used for information retrieval. The aim was to identify whether the PICO search strategy in evidence-based medicine using the MeSH, Emtree and DeCS thesauruses answers a research question in the field of dentistry. Methods: to carry out the PICO strategy, a rese… Show more
“…The protocol for this systematic review was registered in the International Prospective Register of Systematic Reviews (PROSPERO; CRD42021240649) and was carried out based on the Pattern of Reporting Systematic Review and Meta-Analysis (PRISMA) guideline [ 26 ]. The acronym PICO, which corresponds to P = patient or population, I = intervention or indicator, C = comparison or control, and O = outcome, was used to define the guiding question [ 27 , 28 ]. Therefore, in relation to the guiding question of this systematic review and meta-analysis, the acronym PICO corresponds to: P = patients with AD or MCI; I = supplementation with organic or inorganic Se, isolated or in combination with other compounds; C = patients without Se supplementation or who received placebo; and O = improvement in cognitive performance and/or Se availability.…”
Elevated levels of oxidative stress could cause and aggravate Alzheimer’s disease (AD). Selenium (Se) is a trace element with antioxidant and anti-inflammatory activity with neuroprotective effects. To evaluate the effects of Se supplementation in patients with AD or mild cognitive impairment (MCI) through a systematic review and meta-analysis, data were searched and collected from four electronic databases, including clinical trial studies published until December 2020, following the PRISMA guidelines. Statistical analysis was performed by RevMan, and the risk of bias was assessed using the Rob 2 tool. A total of 1350 scientific papers were collected, and following evaluation 11 papers were included in the systematic review and 6 of these were used in the meta-analysis. Studies that evaluated only Se supplementation observed an improvement in Se levels, glutathione peroxidase (GPX) activity, and in some cognitive tests in MCI patients; similarly, improvement in Se levels and mini-mental score was also observed in AD patients. Regarding supplementation of Se plus other nutrients, improvement in cognitive tests was observed in both AD and MCI patients. Therefore, Se supplementation is a good alternative for patients with AD and MCI for improving Se levels and GPX activity. More detailed studies are required to further evaluate the effects of Se on the cognitive deficit and oxidative stress associated with AD and MCI.
“…The protocol for this systematic review was registered in the International Prospective Register of Systematic Reviews (PROSPERO; CRD42021240649) and was carried out based on the Pattern of Reporting Systematic Review and Meta-Analysis (PRISMA) guideline [ 26 ]. The acronym PICO, which corresponds to P = patient or population, I = intervention or indicator, C = comparison or control, and O = outcome, was used to define the guiding question [ 27 , 28 ]. Therefore, in relation to the guiding question of this systematic review and meta-analysis, the acronym PICO corresponds to: P = patients with AD or MCI; I = supplementation with organic or inorganic Se, isolated or in combination with other compounds; C = patients without Se supplementation or who received placebo; and O = improvement in cognitive performance and/or Se availability.…”
Elevated levels of oxidative stress could cause and aggravate Alzheimer’s disease (AD). Selenium (Se) is a trace element with antioxidant and anti-inflammatory activity with neuroprotective effects. To evaluate the effects of Se supplementation in patients with AD or mild cognitive impairment (MCI) through a systematic review and meta-analysis, data were searched and collected from four electronic databases, including clinical trial studies published until December 2020, following the PRISMA guidelines. Statistical analysis was performed by RevMan, and the risk of bias was assessed using the Rob 2 tool. A total of 1350 scientific papers were collected, and following evaluation 11 papers were included in the systematic review and 6 of these were used in the meta-analysis. Studies that evaluated only Se supplementation observed an improvement in Se levels, glutathione peroxidase (GPX) activity, and in some cognitive tests in MCI patients; similarly, improvement in Se levels and mini-mental score was also observed in AD patients. Regarding supplementation of Se plus other nutrients, improvement in cognitive tests was observed in both AD and MCI patients. Therefore, Se supplementation is a good alternative for patients with AD and MCI for improving Se levels and GPX activity. More detailed studies are required to further evaluate the effects of Se on the cognitive deficit and oxidative stress associated with AD and MCI.
“…The databases were chosen for their international recognition and broad multidisciplinary coverage, with the intention of retrieving articles relevant to the subject of the scoping liter-ature review. According to the eligibility criteria, articles that included descriptors related to the terms MeSH (Medical Subject Headings) and DeCS (Health sciences desCriptors) were selected [38]. The terms value-based, care, health, and healthcare were identified from the MeSH and DeCS descriptors and combined with a Boolean operator, as shown in Table 2, to develop a database search to achieve the proposed objectives.…”
Healthcare systems are transforming from the traditional volume-based model of healthcare to a value-based model of healthcare. Value generation in healthcare is about emphasising the health outcomes achieved by patients and organisations while maintaining an optimal relationship with costs. This scoping review aimed to identify the key elements and outcomes of implementing value-based healthcare (VBHC). The review process included studies published from 2013 to 2023 in four different databases (SpringerLink, PubMed, ProQuest and Scopus). Of the 2801 articles retrieved from the searches, 12 met the study’s inclusion criteria. A total of 11 studies referred to value as the relationship between the outcomes achieved by patients and the costs of achieving those outcomes. Most of the studies highlighted the presence of leadership, the organisation of care into integrated care units, the identification and standardisation of outcome measures that generate value for the patient, and the inclusion of the patient perspective as the most prominent key elements for optimal VBHC implementation. Furthermore, some benefits were identified from VBHC implementation, which could shed light for future implementation actions. Therefore, the VBHC model is a promising approach that may contribute to an improvement in the efficiency and sustainability of healthcare.
“…Na primeira etapa a questão de pesquisa foi estruturada com base no acrônimo PICO (Alarcón-Gil, Toro & Baena-Caldas, 2019;Mendes, Silveira & Galvão, 2019), onde descreve P -Problema: Tentativa de suicídio e suicídio; I -Intervenção: Gestão de risco; C -Controle: Hospitalizações; O -Outcomes (desfecho): Segurança do paciente. Assim, a seguinte questão norteadora emerge em: Quais são as ferramentas de gestão utilizadas no gerenciamento do risco e da segurança do paciente em comportamentos suicidas no âmbito hospitalar?…”
Objetivos: Identificar ferramentas de gestão do risco na segurança do paciente com comportamentos suicidas, utilizadas nas emergências hospitalares. Metodologia: Revisão integrativa da literatura, no período de 2017 a 2021, a fim de responder à questão norteadora da pesquisa: Quais são as ferramentas de gestão utilizadas no gerenciamento do risco e da segurança do paciente em comportamentos suicidas no âmbito hospitalar? Utilizou-se a estratégia de busca PICO e a seleção dos estudos foi realizada por dois revisores de forma independente, no qual utilizaram como fontes de buscas as bases do Scopus, Web of Science e Pubmed. Resultados: Identificaram-se 863 artigos, dos quais 8 foram selecionados. Observou-se nos estudos que as ferramentas gerenciais foram: Protocolos de atendimento; Análise do Modo de Falha e Efeitos na Assistência Médica (HFMEA); Lista de Verificação (Check-list) e o Safety Huddle (reunião de segurança). Conclusões: As ferramentas de gestão do risco na segurança do paciente com comportamentos suicidas utilizadas em emergências hospitalares mostram resultados positivos com relação à prevenção ao suicídio nestes ambientes e que contribuem para uma assistência de qualidade e segura, porém carecem de mais evidências científicas.
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