The ever‐expanding landscape of cancer therapeutic approaches

Watson, Christine J.

doi:10.1111/febs.16228

Cited by 6 publications

(7 citation statements)

References 20 publications

(22 reference statements)

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“…As a consequence, normal organs and tissues are also exposed to the harsh environment of chemotherapeutic agents, causing dose-limiting adverse effects and toxicity, which is at the root of the therapy's failure [ 3 ]. It has been extensively studied that most cancers are the result of overexpression of cellular receptors or protein products [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Design and In Vitro Evaluation of Novel Cationic Lipids for siRNA Delivery in Breast Cancer Cell Lines

Vaidya

Jeengar²,

Wadaan

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Breast cancer is the most common cause of cancer mortality in Western nations, with a terrible prognosis. Many studies show that siRNA plays a role in the development of tumors by acting as a tumor suppressor and apoptosis inhibitor or both. siRNAs may be used as diagnostic and prognostic biomarkers in breast cancer. Antisurvivin siRNA was chosen as a therapeutic target in breast cancer treatment because it directly targets survivin, an inhibitor of apoptosis protein, that causes cell death. However, siRNA-based treatment has significant limitations, including a lack of tissue selectivity, a lack of effective delivery mechanisms, low cellular absorption, and the possibility of systemic toxicity. To address some of these issues, we provide a siRNA delivery method based on cationic lipids. In the recent past, cationic liposomes have displayed that they offer a remarkable perspective in proficient siRNA delivery. The presence of a positive charge plays a vital role in firm extracellular siRNA binding along with active intracellular siRNA separation and low biological adversities. Consequently, the methods for developing innovative cationic lipids through rendering and utilization of appropriate positive charges would certainly be helpful for benign and effective siRNA delivery. In the current study, an effort was made to synthesize a 3,4-dimethoxyaniline lipid (DMA) to improve the effectiveness and protection of successful siRNA delivery. DMA cationic lipid successfully delivered survivin siRNA that reduced the survivin mRNA expression, indicating the possibility of utilizing siRNA therapeutics for breast cancer. It is expected that this innovative quaternary amine-based liposome can open up new avenues in the process of developing an easy and extensively used platform for siRNA delivery. Cationic lipoplexes, a potential carrier system for siRNA-based therapies in the treatment of breast cancer, were proven by our data.

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Section: Introductionmentioning

confidence: 99%

Design and In Vitro Evaluation of Novel Cationic Lipids for siRNA Delivery in Breast Cancer Cell Lines

Vaidya

Jeengar²,

Wadaan

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…1 ), covering 'G protein‐coupled receptors' edited by Arun Shukla, (Kanpur), 'Systemic and Cellular Metabolism and Disease’ edited by Colin Adrain (Belfast), ‘COVID‐19: one year on' edited by Paraminder Dhillon (Cambridge) with an introduction by Lawrence Banks (Trieste) and 'Cancer Therapeutics' edited by Christine Watson (Cambridge). All of these Special Issues contain many excellent and informative reviews [4–7], and I would strongly encourage you to browse the content of these issues if you have not already done so. You can find all Special Issues at our journal website here.…”

Section: In Data We Trustmentioning

confidence: 99%

“…We published four Special Issues during 2021 (Fig. 1 Issues contain many excellent and informative reviews [4][5][6][7], and I would strongly encourage you to browse the content of these issues if you have not already done so. You can find all Special Issues at our journal website here.…”

Section: Developments At the Febs Journal During 2021mentioning

confidence: 99%

The FEBS Journal in 2022: trust the science and treasure the data

Martin

2022

The FEBS Journal

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“…Cancer is one of the leading causes of death worldwide [1]. World Health Organization (WHO) reports that breast, colorectal, lung, and liver cancers had the highest incidence and mortality rate in the Eastern Mediterranean Region in 2020 [2].…”

Section: Introductionmentioning

confidence: 99%

The prevalence and predictors of herb-drug interactions among Iranian cancer patients during chemotherapy courses

Bazrafshani

Pardakhty

Khandani

et al. 2023

BMC Complement Med Ther

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Background The concurrent usage of herbal medicines with conventional therapies is an important concern in cancer treatment which can lead to unexpected consequences like herb-drug interactions. This study aimed to determine the prevalence of potential herb-drug interactions and to predict factors associated with herb-drug interactions for cancer patients. Methods This cross-sectional study was conducted among a convenience sample of 315 cancer patients referring to the oncology clinics of Kerman city in 2018. Data were collected via comprehensive face-to-face interviews and medical chart reviews. A drug interaction checker was used to determine herb-drug interactions. The information of patients was compared based on herb-drug interactions using bivariable logistic regression models, and predictors were determined by the multivariable logistic regression model. All analyses were performed by Stata software version 16. Results Of 262 patients (83.2% of the patients) who used herbal medicines, 209 patients [79.8% (95% Confidence Intervals (CI): 75.2 – 85.1)] had potential herb-drug interactions. Chamomile was the most popular herbal medicine (n = 163, 78.0%), and minor and moderate herb-drug interactions were caused by green tea (n = 34, 16.3%) and peppermint (n = 78, 37.5%). The number of chemotherapeutic agents (OR: 1.92, 95% CI: 1.43–2.58; P-value < 0.0001) and the experienced of pain during chemotherapy courses (OR = 2.22, 95%CI:1.00–4.94; P-value = 0.04) were some of the predictors of herb-drug interactions among cancer patients. Conclusion Herbal medicine use during chemotherapy was found prevalent among cancer patients; of them, the experience of potential herb-drug interactions was highly frequent. Oncologists and clinical pharmacologists are recommended to take into account challenges associated with herb-drug interactions in their routine practices, particularly during chemotherapy among these patients.

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The ever‐expanding landscape of cancer therapeutic approaches

Cited by 6 publications

References 20 publications

Design and In Vitro Evaluation of Novel Cationic Lipids for siRNA Delivery in Breast Cancer Cell Lines

Design and In Vitro Evaluation of Novel Cationic Lipids for siRNA Delivery in Breast Cancer Cell Lines

The FEBS Journal in 2022: trust the science and treasure the data

The prevalence and predictors of herb-drug interactions among Iranian cancer patients during chemotherapy courses

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