The Evaluation of Water Sorption/Solubility on Various Acrylic Resins

Tuna, Süleyman Hakan; Keyf, Filiz; Gümüş, Hasan; Uzun, Cengiz

doi:10.1055/s-0039-1697377

Cited by 66 publications

(70 citation statements)

References 22 publications

(32 reference statements)

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“…The effects of NVP grafting on water sorption and solubility of the resulting resins were tested following the specifications of ISO (International Standards Organization) test method 1567 [52, 53]. The hydrophobicity/hydrophilicity of the grafted surfaces was evaluated using a VCA Optima contact angle analyzer.…”

Section: Methodsmentioning

confidence: 99%

Antifungal activity, biofilm-controlling effect, and biocompatibility of poly(N-vinyl-2-pyrrolidinone)-grafted denture materials

Sun

Cao²,

Yeh

et al. 2013

Colloids and Surfaces B: Biointerfaces

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Colonization and biofilm-formation of Candida species on denture surfaces cause Candida-associated denture stomatitis (CADS), a common, recurring disease affecting up to 67% of denture wearers. We developed poly(N-vinyl-2-pyrrolidinone)-grafted denture materials that can be repeatedly recharged with various antifungal drugs to achieve long-term antifungal and biofilm-controlling effects. The monomer, N-vinyl-2-pyrrolidinone (NVP), was grafted onto poly(methyl methacrylate) denture resins through plasma-initiated grafting polymerization. The physical properties and biocompatibility of the resulting resins were not negatively affected by the presence of up to 7.92% of grafted poly (N-vinyl-2-pyrrolidinone) (PNVP). Miconazole and chlorhexidine digluconate (CD) were used as model antifungal drugs. PNVP grafting significantly increased the drug absorption capability of the resulting denture materials. Further, the new materials showed sustained drug release and provided antifungal effects for weeks (in the case of CD) to months (in the case of miconazole). The drug-depleted resins could be recharged with the same or a different class of antifungal drug to further extend antifungal duration. If needed, drugs on the PNVP-grafted denture materials could be “washed out” (quenched) by treating with PNVP aqueous solutions to stop drug release. These results point to great potentials of the new materials in controlling biofilm-formation in a wide range of device-related applications.

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Section: Methodsmentioning

confidence: 99%

Antifungal activity, biofilm-controlling effect, and biocompatibility of poly(N-vinyl-2-pyrrolidinone)-grafted denture materials

Sun

Cao²,

Yeh

et al. 2013

Colloids and Surfaces B: Biointerfaces

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“…Studies by Garcia et al and Monfrin et al confirm that the polymers based on PMMA are characterized by dimensional instability in changeable storage conditions. They are also characterized by water sorption . The self‐cured polymers are distinguished by a lower change in values than those that are heat‐cured, and this is connected with lower residual stress, which arises during processing.…”

Section: Discussionmentioning

confidence: 99%

Effect of Thermocycling on the Shear Bond Strength of Different Resins Bonded to Thermoplastic Foil Applied in Occlusal Splint Therapy

Więckiewicz

Boening

Richter

et al. 2014

Journal of Prosthodontics

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“…[31] The hydrophobicity/hydrophilicity of the samples was evaluated with a VCA Optima contact angle analyzer (AST Products Inc., MA, USA) using the sessile drop technique. Reported water contact angles were the average of at least 5 measurements at different locations on the surface using 1 μL pure water drops.…”

Section: Methodsmentioning

confidence: 99%

Controlling fungal biofilms with functional drug delivery denture biomaterials

Wen

Jiang

Yeh

et al. 2016

Colloids and Surfaces B: Biointerfaces

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Candida -associated denture stomatitis (CADS), caused by colonization and biofilm-formation of Candida species on denture surfaces, is a significant clinical concern. We show here that modification of conventional denture materials with functional groups can significantly increase drug binding capacity and control drug release rate of the resulting denture materials for potentially managing CADS. In our approach, poly(methyl methacrylate) (PMMA)-based denture resins were surface grafted with three kinds of polymers, poly(1-vinyl-2-pyrrolidinone) (PNVP), poly(methacrylic acid) (PMAA), and poly(2-hydroxyethyl methacrylate) (PHEMA), through plasma-initiated grafting polymerization. With a grafting yield as low as 2 wt%, the three classes of new functionalized denture materials showed significantly higher drug binding capacities toward miconazole, a widely used antifungal drug, than the original PMMA denture resin control, leading to sustained drug release and potent biofilm-controlling effects against Candida. Among the three classes of functionalized denture materials, PNVP-grafted resin provided the highest miconazole binding capability and the most powerful antifungal and biofilm-controlling activities. Drug binding mechanisms were studied. These results demonstrated the importance of specific interactions between drug molecules and functional groups on biomaterials, shedding lights on future design of CADS-managing denture materials and other related devices for controlled drug delivery.

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The Evaluation of Water Sorption/Solubility on Various Acrylic Resins

Cited by 66 publications

References 22 publications

Antifungal activity, biofilm-controlling effect, and biocompatibility of poly(N-vinyl-2-pyrrolidinone)-grafted denture materials

Antifungal activity, biofilm-controlling effect, and biocompatibility of poly(N-vinyl-2-pyrrolidinone)-grafted denture materials

Effect of Thermocycling on the Shear Bond Strength of Different Resins Bonded to Thermoplastic Foil Applied in Occlusal Splint Therapy

Controlling fungal biofilms with functional drug delivery denture biomaterials

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