The evaluation of VEGF and HIF‐1α gene polymorphisms and multiple sclerosis susceptibility

Saravani, Mohsen; Rokni, Mohsen; Mehrbani, Mehrzad; Amirkhosravi, Arian; Faramarz, Sanaz; Fatemi, Iman; Tarzi, Mojdeh Esmaeili; Nematollahi, Mohammad Hadi

doi:10.1002/jgm.3132

Cited by 19 publications

(15 citation statements)

References 48 publications

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“…HIF‐1 is a critical regulator of VEGF activation and immune evasion. HIF‐1α induces VEGF transcription by binding to the VEGF gene promoter and recruiting additional transcription factors to the promoter, leading to the upregulation of VEGF messenger RNA (mRNA) expression 81,82 . HIF‐1‐induced VEGF interacts with VEGF receptor 2 (VEGFR2) on the DC membrane, resulting in the upregulation of cofilin 1 (COF1) expression.…”

Section: Hif‐1 Induces Immunosuppressive Molecule and Target Gene Expmentioning

confidence: 99%

The role of hypoxia‐inducible factor 1 in tumor immune evasion

Wang

et al. 2020

Medicinal Research Reviews

173

136

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Hypoxia‐inducible factor 1 (HIF‐1) plays an indispensable role in the hypoxic tumor microenvironment. Hypoxia and HIF‐1 are involved in multiple aspects of tumor progression, such as metastasis, angiogenesis, and immune evasion. In innate and adaptive immune systems, malignant tumor cells avoid their recognition and destruction by HIF‐1. Tumor immune evasion allows cancer cells to proliferate and metastasize and is associated with immunotherapy failure and chemoresistance. In the hypoxic tumor microenvironment, HIF‐1 signaling suppresses the innate and adaptive immune systems to evade immune attack by inducing the expression of immunosuppressive factors and immune checkpoint molecules, including vascular endothelial growth factor, prostaglandin E2, and programmed death‐ligand 1/programmed death‐1. Moreover, HIF‐1 blocks tumor‐associated antigen presentation via major histocompatibility complex class I chain‐related/natural killer group 2, member D signaling. Tumor‐associated autophagy and the release of tumor‐derived exosomes contribute to HIF‐1‐mediated immune evasion. This review focuses on recent findings on the potential mechanism(s) underlying the effect of hypoxia and HIF‐1 signaling on tumor immune evasion in the hypoxic tumor microenvironment. The effects of HIF‐1 on immune checkpoint molecules, immunosuppressive molecules, autophagy, and exosomes have been described. Additionally, the potential role of HIF‐1 in the regulation of tumor‐derived exosomes, as well as the roles of HIF‐1 and exosomes in tumor evasion, are discussed. This study will contribute to our understanding of HIF‐1‐mediated tumor immune evasion, leading to the development of effective HIF‐1‐targeting drugs and immunotherapies.

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Section: Hif‐1 Induces Immunosuppressive Molecule and Target Gene Expmentioning

confidence: 99%

The role of hypoxia‐inducible factor 1 in tumor immune evasion

Wang

et al. 2020

Medicinal Research Reviews

173

136

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“…interleukin (IL)-1, IL-6 and TNF-α, the recruitment of inflammatory macrophages and granulocytes, leading to cytokines storm (CSS), termed as a secondary hemophagocytic lymphohistiocytosis (sHLH) or macrophage activation syndrome, which may follow by disease deterioration, ARDS, septic shock and eventually multiple organ system failure (MOSF) in some patients [ 10 ]. Various studies suggested that genes polymorphisms (SNP) of inflammatory interleukin and chemokine are likely associated with genetic susceptibility to SARS-CoV-2, and probably is responsible for developing different form of COVID-19 in different individuals [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of clinical, para-clinical and laboratory findings in survived and deceased patients with COVID-19: diagnostic role of inflammatory indications in determining the severity of illness

et al. 2020

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Background Since December 2019, when a cluster of pneumonia cases due to SARS-CoV-2 initially emerged in Wuhan city and then rapidly spread throughout the world, the necessity for data concerning the clinical and para-clinical features of Iranian patients with COVID-19 was highlighted. Therefore, we aimed to compare the clinical, para-clinical and laboratory evidences of deceased patients with survival group. Methods We extracted data regarding 233 patients with laboratory-confirmed COVID-19 from Buali Hospital in Iran; clinical/para-clinical and inflammatory indexes data were collected and analyzed. The data of laboratory examinations and chest CT findings were compared between deceased and survived patients. Results The mean age of the patients was 49.8 years and 64% of our patients were male. The acute respiratory distress syndrome occurred in 64 patients, 52 who were admitted to the ICU, which all of them underwent invasive mechanical ventilation, and 28 who died. Lymphopenia (79%), neutrophilia (79%), and thrombocytopenia (21%) were the most frequently observed laboratory findings of the deceased group on admission. Most patients (68%) had a high systematic immune-inflammation (SII) index of > 500 and increased C-reactive protein level (88%). Levels of inflammatory indexes such as neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and SII were documented to be significantly elevated in the deceased group when compared with the patients who survived (P < 0.0001, P < 0.001, P < 0.0001, respectively). The most commonly presented symptoms were fever (70%) and cough (63%) on admission. Headache was uncommon (11%). Ground-glass opacity with consolidation (mixed) was the most common radiologic finding on chest CT (51%). No radiographic or CT abnormality was found in 15 of 204 patients (7%). Conclusion Small fraction of patients with COVID-19 may present without fever and abnormal radiologic findings. Elevated NLR, PLR and SII can be considered as prognostic and risk stratifying factor of severe form of disease.

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“…Various studies suggested that genes polymorphisms (SNP) of in ammatory interleukin and chemokine are likely associated with genetic susceptibility to SARS-CoV-2, and probably is responsible for developing different form of COVID-19 in different individuals [11,12].…”

mentioning

confidence: 99%

Comparison of Clinical, Para-clinical and Laboratory Findings in Survived and Deceased Patients with COVID-19: Diagnostic Role of Inflammatory Indications in Determining the Severity of Illness

Rokni

Ahmadikia

Asghari

et al. 2020

Preprint

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Background: Since December 2019, when a cluster of pneumonia cases due to SARS-CoV-2 initially emerged in Wuhan city and then rapidly spread throughout the world, the necessity for data concerning the clinical and paraclinical features of Iranian patients with COVID-19 was highlighted. Therefore, we aimed to compare the clinical, paraclinical and laboratory evidences of deceased patients with survival group. Methods: We extracted data regarding 233 patients with laboratory-confirmed COVID-19 from Buali Hospital in Iran; clinical/paraclinical and inflammatory indexes data were collected and analyzed. The data of laboratory examinations and chest CT findings were compared between deceased and survived patients. Results: The mean age of the patients was 49.8 years and 64% of our patients were male. The acute respiratory distress syndrome occurred in 64 patients, 52 who were admitted to the ICU, which all of them underwent invasive mechanical ventilation, and 28 who died. Lymphopenia (79%), neutrophilia (79%), and thrombocytopenia (21%) were the most frequently observed laboratory findings of the deceased group on admission. Most patients (68%) had a high systematic immune-inflammation (SII) index of >500 and increased C-reactive protein level (88%). Levels of inflammatory indexes such as neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and SII were documented to be significantly elevated in the deceased group when compared with the patients who survived (P< 0.0001, P< 0.001, P< 0.0001, respectively). The most commonly presented symptoms were fever (70%) and cough (63%) on admission. Headache was uncommon (11%). Ground-glass opacity with consolidation (mixed) was the most common radiologic finding on chest CT (51%). No radiographic or CT abnormality was found in 15 of 204 patients (7%). Conclusion: Small fraction of patients with COVID-19 may present without fever and abnormal radiologic findings. Elevated NLR, PLR and SII can be considered as prognostic and risk stratifying factor of severe form of disease.

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The evaluation of VEGF and HIF‐1α gene polymorphisms and multiple sclerosis susceptibility

Cited by 19 publications

References 48 publications

The role of hypoxia‐inducible factor 1 in tumor immune evasion

The role of hypoxia‐inducible factor 1 in tumor immune evasion

Comparison of clinical, para-clinical and laboratory findings in survived and deceased patients with COVID-19: diagnostic role of inflammatory indications in determining the severity of illness

Comparison of Clinical, Para-clinical and Laboratory Findings in Survived and Deceased Patients with COVID-19: Diagnostic Role of Inflammatory Indications in Determining the Severity of Illness

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